Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eighteen patients with primary abnormalities of neutrophil chemotaxis are described. The most common clinical presentation was one of recurrent upper respiratory tract infection (nine patients) or recurrent pyoderma (seven patients), and two children had a history of oropharyngeal candidiasis and recurrent skin sepsis. Of these eighteen patients, sixteen had intrinsic polymorphonuclear leucocyte (PMN) defects as shown by diminished random migration and movement towards endotoxin-activated serum. PMN chemotaxis towards casein was, however, normal. In nine out of the latter patients, there was an associated inability of the serum to generate chemotactic factors. PMN from two adult patients, both suffering from recurrent boils, moved normally both in random and directed systems, but sera from these patients contained heat-stable inhibitors of neutrophil chemotaxis. In vitro levamisole treatment (10(-3) M) markedly improved the PMN function. When patients were treated with levamisole, however, no clinical response was noted, although PMN movement improved in a number of cases.
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PMID:Defective neutrophil motility and recurrent infection. In vitro and in vivo effects of levamisole. 70 9

Groups A, B, C and G streptococci were cultured from 63 consecutive in-patients recruited between November 1987 and April 1988 and monitored until the end of July 1988. Chronic leg ulcers were present in 34 patients. Group G was found in 34 patients, 25 of whom had pyoderma and 3 had sepsis. Six of the patients had no signs of clinical infection, and treatment with antibiotics was therefore withheld. Recurrent phlegmon or erysipelas developed in 2 of 28 patients with clinical Group G infections. Erysipelas developed some 1-7 months later in 3 of the 6 patients who were not initially treated. No significant difference in severity or additional medical conditions was found between the patients with either Group G or Group A streptococci. In comparison, data on all streptococcal cultures at the Department indicated that Group G was isolated 2.6 times as often as Group A streptococci for the in-patients, compared with 1.1 for all patients seen. It is concluded that Group G streptococcal skin infections must be regarded with the same clinical vigilance as Group A infections.
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PMID:Group G streptococcal infections on a dermatological ward. 135 Mar 98

We studied the clinical efficacy of meropenem (SM-7338, MEPM), a new parenteral carbapenem beta-lactam antibiotic, in pediatric field. Thirteen patients with 2 months to 8 years and 8 months of ages, with acute infectious diseases were administered with doses at 39.3 to 76.7 mg/kg/day of MEPM intravenously. The diagnoses consisted of 7 respiratory tract infections, 1 sepsis, 2 orbital cellulitis, 1 parotid abscess, 1 lymphadenitis and 1 pyoderma. The clinical efficacy rate was 84.6% (11/13), and the bacteriological eradication rate was 71.4% (5/7). Clinical laboratory examinations revealed 1 patient with eosinophilia and another with anemia. No other side effects attributable to this drug were observed. It appears that MEPM is a useful antibiotic for moderate to severe acute bacterial infections in children.
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PMID:[Clinical evaluation of meropenem in the pediatric field]. 150 5

Staphylococcus aureus (SA) is among the most important causes of skin infections. The incidence of Methicillin-resistant SA (MRSA) strains isolated from skin and skin structure infections was about 20-40%. In deep-seated pyoderma such as furuncle and furunculosis, MRSA was more frequently isolated than in other type of infectious diseases of the skin. But the incidence was gradually increasing. As to coagulase typing, type IV was most frequently isolated in MRSA. The damaged skin is easily colonized by high numbers of SA on its surface and within hair follicles. Through the indwelling catheters or decubitus SA on the skin could cause easily severe systemic MRSA infections such as sepsis or endocarditis of in-patients.
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PMID:[Methicillin-resistant Staphylococcus aureus in dermatology]. 150 40

The neonatal morbidity was studied in 7015 neonates born at the All India Institute of Medical Sciences Hospital, New Delhi. The incidence of low birth weight babies was 26.7 per cent; one seventh (13.5%) of the series were preterm (less than 37 wk), while 6.6 per cent were 'small-for-dates'. Birth asphyxia of varying severity developed in 5.9 per cent infants. Respiratory distress syndrome was diagnosed in 5.7 per 100 live-births; most being due to hyaline membrane disease (33.5%), which affected 14.1 per cent of preterm babies. Neonatal hyperbilirubinemia occurred in 5.9 per cent, most of whom were premature. In nearly one-fifth, the cause of jaundice could not be identified after detailed investigations. Minor bacterial infections (conjunctivitis, pyoderma, oral thrush, umbilical sepsis) were observed in 1.8 per cent while major infections (septicemia, meningitis, diarrhoea) in 3.0 per cent. The overall incidence of major malformations was 2.3 per cent. Reasons for low incidence of bacterial infections and common occurrence of hyaline membrane disease in premature infants, are highlighted.
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PMID:A four year study on neonatal morbidity in a New Delhi hospital. 193

The measurement of colloid-oncotic pressure (COP) in 160 women with pyoseptic disease (pyodermia, soft-tissue abscesses, suppurative mastitis, endometritis, sepsis) has demonstrated a regular pattern of change, depending on the clinical condition. A classification of COP disorders has been proposed, identifying the hyperoncotic state (COP above 3.29 kPa), normoncotic state (COP between 2.84 and 3.29 kPa) and hypo-oncotic state (COP below 2.84 kPa), on which a differential remedial therapy is based. A reliable assessment of COP values during the infusion therapy can only be made by means of oncometry, since estimations of any kind lead to considerable error.
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PMID:[Differential correction of disorders of colloid-oncotic blood pressure in pregnant women and puerperants with suppurative-septic diseases]. 273 6

In December, 1984, an outbreak of pyoderma affected five scrum players in the St Thomas' Hospital rugby team. The causative organism, Streptococcus pyogenes, was acquired during a match against a team experiencing an outbreak of impetigo, and was transmitted to two front row players of another team a week later, and to two girlfriends of affected St Thomas' players a month later. The strain was M-type 49, tetracycline-resistant, and virulent. It caused salpingitis in a girlfriend and acute glomerulonephritis in one rugby player. No case of subclinical glomerulonephritis was detected in eight patients with pyoderma. Screening of the St Thomas' Hospital team revealed four further cases of non-streptococcal skin infection, with evidence for contemporaneous spread of Staphylococcus aureus. Teams should not field players with sepsis, and it may be advisable to apply a skin antiseptic to traumatised skin after the match.
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PMID:Scrum kidney: epidemic pyoderma caused by a nephritogenic Streptococcus pyogenes in a rugby team. 287 37

Rooming-in was begun in this hospital in 1981 to serve those families whose newborns were born vaginally. Following positive results with this, the hospital began rooming-in for babies delivered by cesarean section in 1984 if they met certain criteria. However, the facilities for rooming-in for cesarean-delivered babies were still limited so that not every baby who fulfilled the criteria could room with their mother. In 1986, 4112 babies were born and among theses, 848 were delivered by cesarean section. Of these, 435 babies fulfilled the criteria but only 269 babies could room with their mothers; 166 had to be nursed separately. The authors compared the data of the rooming-in babies to those nursed separately. The study showed that among the rooming-in group, more mothers were fully breastfeeding on discharge and the incidence of sepsis, enteritis, and hyperbilirubinemia were significantly lower, while mortality and the incidence of pneumonia, omfalitits, conjunctivitis, and pyodermia did not differ significantly.
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PMID:Rooming-in for babies born by caesarean section in Dr. Cipto Mangunkusumo General Hospital Jakarta. 327 Jul 98

76 children were treated with clindamycin at a dosage of 40 mg/kg/day for postsurgical wound infections, sepsis, phlegmon, peritonitis, osteomyelitis, pneumonia, mediastinitis, pyoderma and urinary tract infections. Frequency distribution of individual infectious agents: Staphylococci, 94,7%; Streptococci, 59,2%; Pneumococci, 5,3%; Enteroccocci, 25%; Escherichia coli, 10,5%; Pseudomonas, 14,5%; Proteus, 7,9%; Bacteroides, 6,6%; Clostridia, 7,9%. Therapy was successful in 83% of cases. Results were poor in 2 children treated for phlegmona, one case of mediastinitis and one of urinary tract infection, since organisms were predominantly gram-negative.
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PMID:[Acute infections in pediatric surgery. Clinical experience with clindamycin (author's transl)]. 677 33

A total of 403 coagulase- and DNAase-negative staphylococcal strains isolated from patients with conjunctivitis, urological diseases, purulent inflammatory processes, septicemia, infected traumas, pyodermia were investigated in 18 biological tests. In a vast majority of cases the absence of correlation between the individual biological characteristics of the strains was revealed. The identification of S. epidermidis and S. saprophyticus, carried out by Akatov et al. in accordance with the schemes of the International Subcommittee, Digranes and Oeding, allowed to determine the species the organisms under test belonged to in 26%, 38% and 64% of the strains, respectively. Most of the identified strains belonged to S. epidermidis. Their biological typing by the methods of Baird-Parker and Akatov-Khatenever allowed the biotype to be determined in 79% and 69% of the cultures. Strains belonging to biotype 1 according to Baird-Peter were most frequently isolated in conjunctivitis, purulent processes and pyodermia, while strains belonging to biotype 2 according to Akatov-Khatenever were prevalent in urological diseases.
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PMID:[Coagulase-negative staphylococci isolated from patients. I. Biological properties and biotyping of the strains]. 723 40


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