Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 17-year-old woman with mitral and tricuspid valve prolapse and myxomatous degeneration presented puerperal infection by Staphylococcus aureus with clinical picture of sepsis and multiple septic embolism (right eye, left thumb, spleen, and left calf). She underwent total hysterectomy on the 10th day postdelivery and right eye enucleation on the 16th. Temporary total AV block occurred on the 14th day with temporary external pacing during the next couple of days. Acute endocarditis with acute mitral regurgitation was diagnosed on the 13th day, demanding immediate valve replacement. On the 46th day she developed moderate tricuspid valve regurgitation due to another episode of endocarditis. Final clinical discharge took place on the 62nd day after antibiotic therapy completion.
 ...
PMID:[Staphylococcus aureus endocarditis in a puerperal woman with mitral and tricuspid valve prolapse]. 209 20

From 1971 to 1980 20 patients at the first department of women of the university of Munich required a puerperal hysterectomy because of septicemia following caesarean section. During the same time a total of 2,726 caesarean sections were performed. 14 of the 20 women requiring hysterectomy had the caesarean section in the first department for women. Six women were referred with septicemia following caesarean section in another hospital. The causative relationship between caesarean section and septicemia was reviewed leading to the indication for hysterectomy. The indications for the caesarean section, risk factors for increased puerperal infection, the postoperative course, the indication for hysterectomy, the findings at operation the findings in the operative specimen and the course following hysterectomy were reviewed. Risk factors promoting an ascending infection postpartum were the type of labor, frequent vaginal examinations, previous attempts at vaginal delivery, and internal fetal monitoring by a scalp electrode. The recognition of incipient septicemia include severe pain in the abdomen and a subjective feeling of severe illness in the patient. The white blood count is increased, the body temperature is high and beginning respiratory insufficiency points to the severity of the illness. In these cases a repeat laparotomy with hysterectomy to eliminate the focus of infection is the treatment of choice for the septicemia. 19 of the patients who required hysterectomy for septicemia following caesarean section were discharged home after a mean hospital stay of 36 days. One of the patients died 41 days following caesarean section and 20 days following hysterectomy because of septicemia resistant to treatment.
 ...
PMID:[Hysterectomy for septicemia following caesarean section]. 655 May 42

At the clinics of Uludag University Medical Faculty's Department of Obstetrics and Gynecology in Bursa, Turkey, clinicians compared data on 24 premature infants whose mothers had received oral ambroxol (1300 mg/day until delivery) with data on 58 premature infants whose mothers did not receive ambroxol to determine whether or not ambroxol reduced infant respiratory distress syndrome (RDS) by promoting fetal lung maturation. RDS occurred in 8% of the infants in the ambroxol group compared to 10% in the control group. The only RDS case to survive had received ambroxol. Sepsis was more common in the control group than the ambroxol group (13% vs. 4%). None of the infants had any concomitant disorder that would have contributed to fetal lung maturation. Ambroxol did not significantly change maternal liver and renal function results. In infant and maternal cases, the blood thyroid hormone levels were within the normal range. None of the mothers in either group developed a puerperal infection. Ambroxol did not cause any significant maternal or infant side effects. These findings suggest that ambroxol may prevent RDS and sepsis. Larger study groups and studies of groups with hypertension, diabetes, and multiple gestations are needed to determine whether ambroxol is a valuable alternative to steroids for prevention of RDS.
 ...
PMID:Antenatal ambroxol usage in the prevention of infant respiratory distress syndrome. Beneficial and adverse effects. 755 58

New Zealand's maternal mortality rate in the triennium 1986-8 was reviewed in comparison with the rates from Australia and the United Kingdom during 1985-7. The New Zealand rate of 9.6 obstetric deaths/100,000 total births was higher than that for the United Kingdom (6.2) and Australia (4.4). Six of 16 deaths in New Zealand during the triennium were caused by sepsis, including five cases of puerperal infection with group A beta-haemolytic streptococci. Careful analysis of maternal deaths in New Zealand remains an important priority to provide audit of the performance of maternity services.
 ...
PMID:Maternal mortality in New Zealand. 841 90

Even today infection is the most important cause of morbidity and mortality after cesarean section. The aim of this paper is to point to the significance of hysterectomy in treatment of puerperal infection in the contemporary obstetrics. During a 15- year period (1981 - 1995) 85231 deliveries were performed at the Clinic for Gynecology and Obstetrics in Novi Sad (Yugoslavia). There were 8609 (10.10%) cesarean sections. Hysterectomy was performed in 16 cases (0.186%) of women undergoing cesarean section due to dehiscence of uterine suture, endometritis, diffuse peritonitis or sepsis. Infection during delivery was diagnosed in 3 (18.75%) cases, the delivery itself began by amnion rupture in 5 (31.25%) cases, it lasted more than 12 hours in 6 (37.50%) cases. Elective cesarean section was performed in 3 (18.75%) cases, cesarean section during delivery in 13 (81.25%) and iterative cesarean section in 5 (31.25%) cases. Total hysterectomy was performed in 9 (56.25%) cases and subtotal in 7 (43.75%) cases. Postoperative treatment by antibiotics was carried out in all cases. There were postoperative complications after hysterectomy in 7 (43.75%) cases. According to results of microbiologic analyses in 7 (43.75%) cases one cause was determined, while in 9 (56.25%) cases two or more causes were determined. Gram-negative-bacteria were the most common cause (68.75%).
 ...
PMID:[Postoperative infection as an indication for hysterectomy after cesarean section]. 869

An analysis of causes of maternal deaths in the Southern Highlands Zone of Tanzania, concentrating on avoidable factors contributing to these deaths, was conducted in 1983. Deaths were ascertained by forms sent to doctors in hospitals and assistants in health centers, by visiting hospital and centers regularly, and from reports to Regional Medical Officers. The majority of deaths occurred in hospitals, producing a maternal mortality rate of 2.5/1000 in hospitals, compared to 0.8/1000 for the Zone overall. Total numbers and notable cases were discussed in each of the following etiologies: ectopic pregnancy (1), sepsis after abortion (20), placenta previa (3), eclampsia (4), postpartum hemorrhage (21), anemia (3), obstructed labor (6), puerperal infection (10), sepsis after surgery (7), puerperal pulmonary embolism (2), aspiration after anesthesia (1), herbal medicines (2). The greatest number of deaths were in gravida 3 women. The main avoidable factors were lack of blood for transfusion, no partogram being kept in labor, and risk factors noted but not acted upon. Blood was not available for several reasons: blood not kept in maternity ward, equipment not available to transfuse and relatives refused to give blood. Some other avoidable risk factors were: lack of or slow transport to facility, interference abortion, no antenatal care, lack of gas gangrene serum, packing vagina with cloths to stop bleeding, staff errors. It was felt that isolation of rural doctors contributed to errors, which may possibly be avoided by holding periodic seminars and reviews.
 ...
PMID:Preliminary report on maternal deaths in the Southern Highlands of Tanzania in 1983. 1228 47

Even in the 21st Century, approximately 60,0000 women die of pregnancy-related causes each year. WHO reported that 98% of these deaths occur in developing countries; the largest gap between rich and poor nations was evident in the maternal mortality levels. In developed countries, massive hemorrhage and thrombo-embolism are the most frequent causes of maternal death, while in developing countries perinatal infection is the leading cause. In the oldest Japanese classic tale, Kojiki, the goddess Izanami no mikoto, one of the creators of Japan, was killed by her last son, Kagutsuchi, a deity of fire who burned his mother's birth canal. We propose that this tale reflects the incidence of local puerperal infection and subsequent sepsis, the greatest health risk to mothers in ancient Japan.
 ...
PMID:The death of Izanami, an ancient Japanese goddess: an early report of a case of puerperal fever. 1676 14

Sepsis is one of the main causes of maternal death, being related to infections from obstetric origin (infected abortion, chorioamnionitis, puerperal infection) or non-obstetric (resulting from infections which occur in other areas). This review aims at describing the mechanisms involved in the physiopathology of this entity and at updating the clinical approach to sepsis, recommended in international guidelines (early goal-directed therapy--precocious resuscitation, or precocious treatment guided by goals), as well as at calling attention to the influence of pregnancy both in the clinical manifestation and in the therapeutic management of septic conditions.
 ...
PMID:[Sepsis and septic shock during pregnancy: clinical management]. 1921 46

An exceptional case of a 15-year-old puerpera with septic shock caused by Group A beta-hemolytic Streptococcus and Waterhouse-Friderichsen syndrome is reported. The findings were observed at the necropsy. The characteristics of the diagnosis, pathogenesis and evolution of this puerperal infection (sepsis), associated with adrenal hemorrhage and insufficiency are reviewed in this paper.
 ...
PMID:[Puerperal septic shock due to beta-hemolytic Streptococcus and Waterhouse-Friderichsen syndrome]. 1928 40

A classification is made of 219 cases notified as puerperal fever or puerperal pyrexia. Of these, 71 were local uterine infections; 47, pelvic or general peritonitis; 11, pelvic cellulitis; 20, septicaemia or pyaemia; 12, pyelitis, and 58, febrile conditions not due to infection of the genital tract. Fatal cases were all due to general peritonitis or blood infections and the general death-rate for infections of the genital tract is 21.4 per cent. Of 32 maternal deaths, 7 followed abortion; 11 occurred in primiparae, the preponderance of whom showed more or less severe trauma, and 13 in multiparae in whom trauma was absent in the great majority. Similar antecedent circumstances were found in recovered cases of puerperal infection; from these figures an attempt is made to assess the importance of trauma in the production of sepsis. Two cases of puerperal scarlet fever are described and the transmission of infection in puerperal sepsis is discussed. A study has been made of sensitiveness to the haemolytic streptococcal toxin in 103 cases of puerperal sepsis and the results do not bear out the suggestion that infection by the streptococcus in the puerperium is correlated with toxin sensitiveness.
 ...
PMID:Puerperal Fever and Pyrexias. 1998 71


1 2 Next >>