Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

All consecutive women admitted for complications of induced abortion at the Obafemi Awolowo University, Nigeria, from November 1988 through December 1989 were studied and interviewed. The interviews, conducted at the end of the stay by the staff member with most rapport with the women, asked about the abortion method, abortionist, cost patient's socioeconomic background, knowledge and practice of contraception, and knowledge and attitude toward the Nigerian abortion law. The 74 admissions accounted for 12% of all gynecological admissions. The patients ranged in age from 15 to 49, mean 22.8 years, and parity from 0 to 8, median O. 42% were ever married. 80% were Christians. The abortions were performed in 32% of cases by medical practitioners, 27% by non-medical persons, and 19% were self-induced. Self-induction methods included coat hangers, injections, ingestion of strong alcohol or tablets, instillation of native pessaries, potash, or gunpowder vaginally. Complications included sepsis (84%), hemorrhage (51%), uterine perforation (8%), cervical laceration (4%), septic shock (4%), perforation of gut or bladder, pelvic abscess, and psychosis. Treatment was broad spectrum antibiotics in all cases, evacuation of retained products in 76%, laparotomy in 7%, and hysterectomy in 2 cases. Hospital stay ranged from 1 to 60 days (mean 9.8). There were 13 maternal deaths (18%), or 35% of total maternal deaths in the hospital in this period. Sepsis was the cause of all deaths except one from hemorrhage. 54% of the fatal abortions were done by medical personnel, although none were obstetricians. In interviews of 20 subjects, it was learned that the majority of their abortionists were physicians, and costs ranged from $2 to 25 (US). All 20 women knew about effective contraception, but did not use it because they feared side effects, disliked the lack of privacy in clinics, and could not afford private providers. Only 4 knew that abortion is illegal in Nigeria, and only 2 thought it should be legalized, because they believed it is immoral. Contrary to common opinion, these women included married as well as single women, and the deaths were caused by physicians as well as lay abortionists.
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PMID:Illegal induced abortion: a study of 74 cases in Ile-Ife, Nigeria. 144 Aug 96

Ciprofloxacin is the most potent post-marketing fluoroquinolone. In vitro activity and pharmacokinetic properties of this agent, together with clinical trials of the drug may be very promising in the treatment of severe infections, especially when the bacteria involved are resistant to other conventional agents. We performed an open clinical trial of this agent in hospitalized patients with severe infections in a university hospital in Bangkok, Thailand. A total of 25 patients were enrolled on the basis of clinical diagnosis of severe bacterial infections. Six of these patients were dropouts (3 of which proved to be non-bacterial infections, 2 patients each had only anaerobic infection and nocardiosis. One suffered from a severe psychotic attack). The remaining 19 patients were evaluated. There were 12 males and 7 females, the age ranged from 13 to 77 years old (43.2 +/- 20.1). Most had severe underlying illnesses (17 out of 19). There were 23 infections in 19 patients. Septicemia was the most common infection treated. Other infections included complicated urinary infection, upper respiratory tract infection, skin/skin structure infection. P. aeruginosa was the most common pathogen infected. Other organisms were E.coli, Enterobacter, P.mirabilis, S.aureus, A.antitratus and mycobacterium. Ciprofloxacin was given as an initial 100 mg twice daily as intravenous infusion, and this was switched to an oral form of 500 mg b.i.d./at approximately day 4 to day 6. The overall cure rate was 68 per cent. There were 2 improvements, 2 relapses/reinfections and one failure. Toxic effect included one psychotic attack necessitating discontinuation of the drug. Other adverse drug reactions were mild and transient. These included elevation of transaminase and LDH.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Ciprofloxacin in severe infections. 223 Jun 26

Forty cases of drug-induced agranulocytosis from the Department of Medicine, Faculty of Medicine, Chiang Mai University during the 12 year period 1975-1987 were analysed. In 32 cases, the related etiologic drugs were identified. These were thiacetazone and isoniazid in 10 cases (25%), propylthiouracil in 6 cases (15%) sulfa drugs in 5 cases (12.5%) combination of analgesic and antibiotics in 3 cases (7.5%), anti-psychotic in 2 cases (5%), antibiotics in 5 cases including, ampicillin (2 cases) and others (3 cases), and ether in 1 case (2.5%). The other 8 cases (20%) received unknown drugs from private clinics. Twenty-four cases had complete recovery in 13-14 days after withdrawal of the incriminating drugs, and sixteen cases (40%) died with septicemia.
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PMID:Drug-induced agranulocytosis. 262 33

An autopsy case of a 66 year-old woman is reported. She developed personality change and psychotic symptoms at the age of 58. She began to show gait disturbance and forgetfullness at the age of 60. She was admitted to Okayama University Hospital at the age of 61, when she showed personality change, dementia, cerebellar sings and chorea like involuntary movement. The illness progressed slowly and she died of septicemia at the age of 66. At autopsy brain weighed 990 g. Macroscopically, the atrophy of the brain stem was severe, and the cerebellum was slightly atrophic. Microscopically, the globus pallidus was almost intact, but the degeneration involved dentate nuclei, their projections, red nucleus and the subthalamic nuclei, so this case was considered to be a case of pseudo-Huntington form of dentatorubropallidoluysian atrophy, proposed by Hirayama. The most striking feature of this case was marked atrophy of the brain stem and her intense familial history. Investigation of her familial history revealed that there were 18 affected cases in 5 successive generations. Their onset of the disease varied from the age of 10 to 60 years old. Cases of juvenile onset showed myoclonus and convulsion as the initial symptoms, and convulsion as the initial symptoms, and those of presenile onset showed dementia, cerebellar ataxia and chorea like involuntary movement. And in some of these cases it was proved by NMR-CT that their brain stem were small. We discussed the meaning of the atrophy of the brain stem in these cases and the difference of the symptoms between the cases of juvenile onset and the cases of presenile onset.
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PMID:[An autopsy case of dentatorubropallidoluysian atrophy showing marked atrophy of the brain stem]. 296 93

In 18 of 20 patients with psychosis secondary to systemic lupus erythematosus (SLE), autoantibodies to ribosomal P proteins were detected by immunoblotting and measured with a new radioimmunoassay using a synthetic peptide as antigen. The frequency of anti-P was not increased in patients with other central nervous system manifestations of SLE (3 of 20, by radioimmunoassay), in patients with transient behavioral abnormalities due to SLE (none of 8), in patients with psychosis who did not have SLE (none of 13), or in normal controls (none of 20). In four of five paired serum samples, anti-P-peptide antibody levels increased 5-fold to 30-fold during the active phase of lupus psychosis. Longitudinal studies of anti-P activity in two patients with psychosis revealed that anti-P levels increased before and during the active phases of psychosis but not during sepsis or other exacerbations of SLE, and that the elevations were selective for anti-P antibodies, as opposed to anti-DNA antibodies. Longitudinal studies of anti-P activity in two patients with anti-P but without psychosis showed less than threefold changes in anti-P levels despite exacerbations of disease. We conclude that anti-P is associated with lupus psychosis and that synthetic peptide antigens may be useful for the detection and measurement of autoantibodies to intracellular proteins.
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PMID:Association between lupus psychosis and anti-ribosomal P protein antibodies. 349 38

Out of 908 patients with sepsis treated at the Republican Antisepsis Center, 19 presented with different schizophrenia syndromes (2 with acute delirium, 3 with encephalic manifestations, 3 with the amentive-catatonic form, the remainder with the amentive-depressive form). In 6 patients, psychic disorders preceded fever, in 3 patients, both conditions occurred simultaneously, and 9 developed psychosis in the presence of fever. In all the patients, with the exception of one, the diagnosis of sepsis was supported by repeated isolation of hecocultures of S. epidermidis (14 cases) and S. aureus (4 cases). The patients received antisepsis treatment. Two patients died and the rest 17 patients were cured of sepsis. The schizophrenic syndrome disappeared. No relapses were recorded with the exception of one female patient, in whom both sepsis and psychic disorders recurred. Later on, however, she also recovered.
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PMID:[Schizophrenia syndromes caused by infection]. 371 38

Following the administration of fluphenthixol (a depot phenothiazine) for a psychotic illness, a 44-year-old woman developed weakness, rhabdomyolysis and renal failure, together with hyperthermia (42 degrees C) and signs of both autonomic and central nervous system dysfunction. She died following massive intestinal haemorrhage, intra-abdominal sepsis and probable disseminated intravascular coagulation. A diagnosis of neuroleptic malignant syndrome had been made, but treatment with dantrolene sodium was probably instituted too late to prevent the progress of the complications she had developed. This syndrome, which follows the use of phenothiazines or butyrophenones, is rare, potentially fatal and probably underdiagnosed. It has been likened to malignant hyperthermia, but a review of the literature points to many differences. Both dantrolene sodium and dopaminergic drugs (bromocriptine, amantidine and L-dopa) have been shown to be efficacious and their continued use, despite a failure in this case, is advocated until more is known about this syndrome.
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PMID:The neuroleptic malignant syndrome. Case report with a review of the literature. 382 73

The authors present 2 cases of post-abortion psychosis and discuss the etiology of this complication from the literature. Psychosis after abortion is rare, estimated at 0-1% in 2 studies, and 6 cases in 15 years experience of 32 psychiatrists in another. The suggestion that illegal abortion is more likely to precipitate psychosis is based in part on the greater possibility of gas embolism and consequent neurologi c lesions. Neurologic symptoms such as sensory, motor, pyramidal and ex trapyramidal signs and epileptic crises could results from scar tissue in the central nervous system. The first patient was a 31-year old mother of 1 illegitimate daughter, in conflict with her partner about having the abortion. After attempting abortion with soap solution she was hospitalized for coliform shock and sepsis complicated by gastric ulcers. 3 weeks alter she became psychoitic, with alternating aggressio n, exhibitionism, infantile behavior and catatonia. After release from the hospital she committed suicide. The second patient had marital conflicts, related to fear of pregnancy, and narcicistic desire for consumer goods instead of children. After she became pregnant with an IUD in place, the abortion commission, at first ambivalent, granted abortion, which required 2 curretage procedures. She had delerium and paranoia concerning her 5 abortions. The authors remarked that the trau ma of abortion may precipitate pscyhosis in a disturbed personality with inner or outer conflicts; it is impossible to predict when decompensation might occur, even if the pregnancy is carried to term.
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PMID:[2 cases of post-abortion psychoses]. 546 32

The cases of 135 consecutive elderly patients 70 years old or older who had valve replacement and related surgical procedures from October, 1977, through April, 1982, were reviewed. There were 75 men and 60 women. The mean left ventricular ejection fraction was 50.16 +/- 5%. The overall operative mortality was 8% (11 patients). The early operative deaths were related mainly to cardiac failure, low cardiac output, sepsis, and renal and multiorgan failure. To assess the operative risk, these 135 patients were compared with 312 younger patients (less than 70 years old) who had undergone similar procedures during the same period. The operative mortality in this group was 5.2% (16). In-hospital complications included arrhythmia (13%), psychosis (7.4%), respiratory failure (6.7%), renal failure (6.7%), cerebrovascular accident (5.2%), myocardial infarction (4.4%), and reoperation for bleeding (2.2%). Wound dehiscence occurred in 1.5% of the patients, and pulmonary emboli and sepsis developed in 0.7%. Of these complications, only the incidence of cerebrovascular accident appeared to be more common in the elderly group (5.2% versus 2.8%), but it had no statistical significance (p = 0.18). A follow-up of 3,892 patient-months was completed in 98.4% of the survivors. There were 8 late deaths (6.4%). Six were related to the valve or to ongoing cardiovascular disease. Thirty-four patients subsequently required medical attention: 4 had bleeding because of the anticoagulant; 3 required a blood transfusion; and 27 were hospitalized. Six were admitted for related cardiac conditions and 7, for observation of other conditions; 14 underwent surgical procedures not related to the cardiovascular system.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Should valve replacement and related procedures be performed in elderly patients? 633 51

Thirty-six patients were operated upon for terminal ileal perforations in a two-year period; four cases were due to trauma, four to ascariasis and 28 to typhoid. Ileal perforations due to ascaris worms are differentiated from typhoid ileal perforations because worms are usually found lying freely in the peritoneal cavity or in close association with the perforations. Also, tests for Salmonellae and Shigella are usually negative. Factors affecting mortality and morbidity in typhoid ileal perforation include the age of the patient, duration of perforation before surgery, presence of additional complications, such as massive rectal bleeding, the extent of the surgery, and the number of perforations present. Chloramphenicol in massive doses is indicated for all these patients. Our experience suggests that the hematoxicity of this drug has been over-rated. Postoperative complications are: wound infection (about 95% of cases), malarial fever, septicemia, fecal fistula, intraabdominal abscess, pulmonary infection, jaundice and transient psychosis.
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PMID:Typhoid perforation: factors affecting mortality and morbidity. 716 Sep 89


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