Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute bacterial prostatitis, an acute infection of the prostate gland, results in lower abdominal pain, flank pain, urinary symptoms and the potential for systemic symptoms like fever and shock. With a high mortality rate if left untreated, acute bacterial prostatitis becomes a true urological emergency, which if allowed to progress, may result in bacteremia, severe sepsis/septic shock and death. Diagnosis is mainly clinical with a detailed history and physical and laboratory evaluation to include a urinalysis. However, imaging may be necessary to exclude other pathology. We present the case of a 44-year-old male with a history of well-controlled HIV that used a prostate vibrator for 1-week prior to his presentation to the ED. He was subsequently diagnosed with septic shock secondary to acute bacterial prostatitis and required ICU management.
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PMID:Septic shock secondary to acute bacterial prostatitis in an HIV-positive male: a novel presentation. 3036 94

Corynebacterium urealyticum is a well-known opportunistic uropathogen that can occur with cystitis, pyelonephritis, and urinary sepsis. Although a wide variety of coryneform bacteria have been found from the male genital tract of prostatitis patients, only one clinical case of prostatitis caused by C. urealyticum has been reported. The aim of this study was to evaluate the in vitro tropism of C. urealyticum towards LNCaP (lymph node carcinoma of the prostate) human cells line and the influence of acetohydroxamic acid as an irreversible urease inhibitor on different aspects of its pathogenicity by means of several in vitro tests, such as the determination and analysis of growth curves, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the production of biofilms, and adhesion to LNCaP and HeLa cell lines. Results have brought new pieces of evidence on the in vitro tropism of C. urealyticum for the human prostate cell line LNCaP and the therapeutic use of the irreversible urease inhibitors such as acetohydroxamic acid (AHA), not only as enzyme blockers to facilitate the removal of encrustations but also as modulators of some pathogenic mechanisms. These interesting preliminary data allow us to assert that there is a real possibility that C. urealyticum is a new candidate for chronic idiopathic prostatitis.
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PMID:Preliminary in Vitro Studies on Corynebacterium urealyticum Pathogenetic Mechanisms, a Possible Candidate for Chronic Idiopathic Prostatitis? 3221 12

Emphysematous prostatitis is a rare, clinical condition characterized by gas and abscess formation in the prostate often associated with features of sepsis. We report a case of 60-year-old gentleman presenting with emphysematous prostatitis complicated with secondary psoas abscess and florid sepsis following prostate biopsy.
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PMID:Emphysematous Prostatitis With Secondary Psoas Abscess-A Lethal Outcome Following Prostate Biopsy. 3238 Jan 57


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