Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum concentrations and urinary recovery rates of ceftizoxime (CZX) were investigated in 13 mature newborns and 16 premature newborns (with ages 1-17 days) after one shot intravenous injection of 10 and 20 mg/kg, respectively, for treatment and prophylaxis of various infections. Obtained data were studied comparatively among the 3 groups, i.e. the 1st group (age: 0-3 days), 2nd group (age: 4-7 days) and 3rd group (age: 8 days or older). The clinical investigation was made in 9 male and 6 female newborns aged 3-34 days including 4 pediatrics patients with septicemia (1 with purulent meningitis, 1 with urinary tract infection, 1 with Staphylococcal pneumonia and 1 without complication), 1 with maxillary sinusitis, 5 with bronchopneumonia and 5 with urinary tract infections. 1. Serum concentrations and urinary recovery rates (1) Mature newborns given one shot intravenous injection of 10 mg/kg Serum concentrations of the drug in the 1st, 2nd and 3rd groups in 30 minutes after one shot intravenous injection of 10 mg/kg peaked at 18.9-23.3 micrograms/ml, without any significant differences, and thereafter gradually declined to 2.10-4.99 micrograms/ml at 8 hours. Serum half-lives were shorter in older subjects and values in the 3 groups were 3.89, 2.99 and 2.35 hours, respectively. Urinary recovery rates ranged from 55.5% to 70.0% at 8-6 hours in the 3 patients. (2) Mature newborns given one shot intravenous injection of 20 mg/kg Serum concentrations of the drug in the 3 groups peaked in 30 minutes after one shot intravenous injection of 20 mg/kg at, respectively, 36.9, 41.4 and 38.4 micrograms/ml, and thereafter they gradually declined to 9.0, 7.3 and 4.5 micrograms/ml at 8 hours, respectively. Serum half-lives were shorter in older subjects and values in the 3 groups were 3.59, 2.93 and 2.49 hours, respectively. Urinary recovery rates ranged from 43.5 to 78.2% within 12 hours in 2 patients, within 8 hours in 2 patients and within 6 hours in 1 patient. (3) Premature newborns given one shot intravenous injection of 10 mg/kg Serum concentrations of the drug in the 3 groups peaked in 30 minutes after one shot intravenous injection of 10 mg/kg at, respectively, 27.9, 21.5 and 23.0 micrograms/ml, and they gradually declined thereafter to 10.8, 6.2 and 6.5 micrograms/ml at 8 hours, respectively. Serum half-lives were shorter in older subjects and values in the 3 groups were 5.28, 4.43 and 4.24 hours, respectively.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:[Pharmacokinetics and clinical studies of ceftizoxime in newborn and premature infants]. 305 Jan 90