Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Experiments on the active protection of mice from ozenous infection in its two forms, generalized (acute sepsis) and local (plantar infiltration), have demonstrated that immunity, induced by experimental heat-killed ozena vaccine (Klebsiella ozaenae strain 2211, antigens 02B:K4) introduced in a single injection, is characterized by sufficiently high intensity (the degree of protection increases up to 10,000-fold) and duration (at least 30 days). In both forms the development of immunity is characterized by a rapid rise of its intensity to the maximum level (achieved by the end of week 1), subsequent decrease by weeks 3-4 and disappearance by days 50-60 after immunization. Immunity becomes more intense with the increase of the number of injections if these injections are separated by sufficient intervals (up to 14 days). The optimum schedule used in the study of postvaccinal immunity to experimental generalized and local ozenous infection consists of the subcutaneous injection of K. ozaenae strain 2211 in a dose of 250-500 million microbial bodies per mouse with the subsequent challenge with the virulent strain on week 2 from the date of immunization.
 ...
PMID:[The intensity and dynamics of the development of immunity in the administration of experimental corpuscular ozena vaccines]. 341 35

For the first time high preventive properties of sera obtained from ozena patients and healthy persons have been established on the model of acute ozena sepsis. The preventive properties of sera obtained from ozena patients and containing antibodies to the somatic antigens of the causative agent of ozena (O-antibodies) are higher than those of sera obtained from healthy persons. But this effect is linked not with O-antibodies, but probably with the presence of antibodies to the capsular antigen of the microbe (C-antibodies), which are not detected in the agglutination test. The indirect proof of the presence of C-antibodies in the sera of ozena patients, containing O-antibodies, have been obtained due to the ability of C-antibodies to enhance in vivo and to decrease in vitro the bactericidal activity of sera obtained from such patients.
 ...
PMID:[Role of immune and normal sera in protection from ozena]. 733 12

Klebsiella ozaenae (K. ozaenae) is a causative pathogen of some rare diseases such as primary atrophic rhinitis and ozena. Here, we describe one case of a potentially lethal kind of K. ozaenae infection in which multiple organs were implicated. A 40-year-old diabetic male patient presented to our hospital due to fever with right anterior chest mass and neck and shoulder pain for half a month. Based on all examination results, he was diagnosed with sepsis, bilateral pulmonary/right chest wall/liver abscesses and 5th cervical vertebra bone destruction with prevertebral abscesses, all related with K. ozaenae infection. During the first time of admission, he was treated with antimicrobials without operations. Twelve days after his first discharge, fever and pain occurred again, the patient was treated with antimicrobials, operations (anterior debridement, spinal canal decompression, iliac bone graft fusion and internal fixation) and rehabilitation at second admission. The patient recovered well and was discharged from hospital. This case report demonstrates that K. ozaenae can trigger a wide range invasive infections. Particularly, 5th cervical vertebra bone destruction was first reported as a clinical manifestation of K. ozaenae infection in our patient.
 ...
PMID:Multi-Organ Abscesses and 5th Cervical Vertebra Bone Destruction Related with Klebsiella ozaenae Infection: A Case Report. 3328 57