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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fluconazole is a novel triazole antifungal agent developed by Pfizer Inc. and available in both oral and intravenous forms. It is characterized by a long serum half-life of 25 to 30 hours and good absorbability into tissues. In the present study, fluconazole was given to 12 patients with deep mycosis orally, intravenously or by local infusion. The patients included 4 cases of candidemia, 1 case each of candidemia and candiduria, candiduria, esophageal candidiasis, Candida hepatic abscess, pulmonary cryptococcosis and septicemia due to unspecified yeasts and 2 cases of pulmonary aspergillosis. Clinical efficacies of fluconazole against these infections were excellent in 2 cases, good in 8 and fair in 2. None of the patients reported any side effects. From the results of the study, fluconazole appears to be a useful and safe drug for the treatment of deep seated mycosis.
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PMID:[A clinical evaluation of fluconazole in the treatment of deep mycosis]. 254 Mar 60

Fluconazole, a triazole antifungal agent newly developed by Pfizer Inc.. was given orally to 4 patients with deep mycosis. Fluconazole was markedly effective against septicemia due to Candida and oral candidiasis accompanied with lingual ulcer in spite of seriousness of these underlying disease. In 2 patients with aspergilloma, eradication or contraction of fungus ball was observed and the drug was judged to be effective. In vitro MICs of fluconazole against clinically isolated Aspergillus spp. were much higher than its serum levels leaving a large discrepancy between in vitro activity and clinical efficacy. Although the dosage was 100-300 mg daily for 8 days to 6 months, neither adverse reactions nor laboratory parameter abnormalities were observed. The above results suggest that fluconazole is a useful agent in the treatment of fungal infections.
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PMID:[Clinical evaluation of fluconazole in patients with mycotic infection]. 254 Mar 61

Clinical and pathologic findings in a 65-year old woman with fever of unknown origin are described in this report. Generalized aspergillosis with endocarditis was demonstrated at autopsy. The patient had no recognized risk factors for the development of fungal infection. A functional transvenous pacemaker lead, inserted 2 years previously, was completely encased in a large infected thrombus and may have been the initial site of infection. Septicemia and endocarditis are rare but well-described complications of cardiac pacing, and should be considered in the differential diagnosis of fever of unknown origin in patients with pacemakers.
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PMID:Disseminated aspergillosis and pacemaker endocarditis. 258 Feb 83

Among patients of an allergological center there appeared cases of respiratory and cutaneous allergy provoked by fungal infection Paecilomyces varioti Bainier. In the soil the fungi occurred in the mycelial form while in humans and animals the infection manifested in a parasitic hemotropic-tissue form. Pathogenesis of the disease is related to chronic sepsis-like state produced by the persistence of parasitizing hemotropic-tissue Chlamydiaceae-like fungi in blood and tissue cells, sensitization to them, impairments of small and medium size vessels by immunocomplex type, and delayed hypersensitivity in tissues.
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PMID:[Paecilomycosis]. 261 94

A case of invasive Geotrichum capitatum infection is reported; a young patient had an acute leukemia for which he received a chemotherapy, and presented sepsis with blood cultures for Geotrichum capitatum, namely Dipodascus spicifer; this pathogen only described in cactus rot, is responsible for the first case of a human disseminated infection reported in literature. Then he developed a splenic and epididymic infection, with positive cultures for Geotrichum capitatum after splenectomy and castration. Treatment with amphotericin B and itraconazole was started with low minimal inhibitory concentration (0.1 microgram/ml). The patient died of massive hemoptisis. Autopsy findings demonstrated a lung, brain and kidneys seeding.
Mycoses 1989 Nov
PMID:Disseminated Geotrichum capitatum infection in a patient with acute myeloid leukemia. 261 81

This study is based on the analysis of 44 cerebrospinal fluid (CSF) samples from 11 patients with central nervous system (CNS) Candida infection. Risk factors for CNS fungal infection were present in all patients. Five had a chronic meningitis syndrome; two had acquired immunodeficiency syndrome (AIDS); two had cranial trauma followed by chronic meningities; one had intravascular disseminated coagulation syndrome and sepsis; and one had systemic candidiasis after kidney transplant. Etiological diagnosis was made in all by the CSF examination. Nine cases had positive CSF culture for Candida. Two patients presented the yeast in the direct examination, and one of them had reagent complement fixation test for Candida in three successive samples of CSF. Changes found in the CSF composition are discussed in order to evaluate the inflammatory response to CNS infection by Candida.
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PMID:[Cerebrospinal fluid in infection of the central nervous system by yeasts of the genus Candida: analysis of 11 cases]. 261 11

The infectious complications of 31 orthotopic heart transplants in 27 patients performed between 1982 and 1987 were reviewed. Fifteen patients (56%) are alive 704 to 1829 days posttransplantation. Five of the 27 patients died within the first week posttransplantation of noninfectious causes. Infection occurred in 17 of the remaining 22 patients and was the major cause of death in 3 of the 12 fatalities. There were 10 proved and 4 probable bacterial infections. Three of the 10 proved bacterial infections were cases of sepsis with focal complications (two Pseudomonas aeruginosa, one Serratia marcescens) resulting in 2 deaths. The cases of sepsis occurred within 12 days of transplantation. There were 11 viral infections. Cytomegalovirus accounted for 7 of these including 1 fatal and 2 nonfatal episodes of disseminated disease. The mean time of onset of cytomegalovirus infection was 33 days. Two cases of fungal disease were identified at autopsy. One additional patient who received intense immunosuppression because of chronic rejection developed Pneumocystis carinii pneumonia. The most frequent site of infection was the lung with early pneumonias caused by Gram-negative bacteria and later episodes by viral (cytomegalovirus or respiratory syncytial virus) agents.
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PMID:Infections in pediatric orthotopic heart transplant recipients. 264 68

Deep mycoses present new aspects characterized by deep, visceral mycotic localisations and septicemia, particularly in immunocompromised conditions. In immunodepressed patients (leukaemia, transplantation), the granulopenia descending to 500 elements/ml leads not only to invasive aspergillosis and candidosis but also to infections due to opportunistic fungi exceptionally or never seen formerly. AIDS favours opportunistic fungi related to defective cellular immunity as Cryptococcus neoformans, responsible of severe meningoencephalitis and septicemia, as Candida albicans responsible of thrush and oesophagitis, but also true pathogenic fungi (Histoplasma capsulatum) becoming opportunistic in such conditions. C. albicans provokes in heroin addicts a new septicemic syndrome with cutaneous, ocular and osteoarticular lesions and in leukaemic patients hepatic micro-abscesses soon after the neutropenic phase induced by chemotherapy. New methods for immunologic diagnosis (research of circulating fungal antigen), for clinical diagnosis (scanning, magnetic resonance). New strategy of antifungal chemotherapy (itraconazole, fluconazole) allow to a better knowledge and control of this new infectious pathology.
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PMID:[Current role of deep mycoses in infectious pathology]. 281 46

Fungal infection of central venous catheters is well described. Peripheral fungal thrombophlebitis, however, has only been recognized recently, is thought rare, and is poorly characterized as to clinical presentation and treatment. We report the cases of eight patients with peripheral Candida thrombophlebitis. Patients were elderly and critically ill. All had received broad-spectrum antibiotics. Skin colonization appeared the source of contamination. Sepsis, shock, and organ failure were frequent. Physical findings of fungal phlebitis may be subtle, and diagnosis is often delayed. Multiple sites are frequently involved. Treatment necessitates radical excision of suspected veins and systemic antifungal chemotherapy. Persistent fungemia suggests inadequate phlebectomy or the existence of further affected veins. Peripheral thrombophlebitis is probably a common source of fungal sepsis and should be considered in all patients with fungemia. Without aggressive surgical intervention, survival is unlikely.
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PMID:Surgical management of fungal peripheral thrombophlebitis. 292 53

Nonmalignant causes of Pancoast's syndrome are extremely rare. The authors report the case of a 32-year-old man, receiving treatment for acute lymphoblastic leukemia, who had a clinical picture resembling that of Pancoast's syndrome. Invasive mucormycosis was diagnosed as the cause of the syndrome at emergency thoracotomy undertaken to control massive hemoptysis. In spite of adequate treatment, the patient died 5 weeks postoperatively of overwhelming sepsis. A review of the literature disclosed only two other similar cases. The authors conclude that the development of Pancoast's syndrome in the immunosuppressed patient should raise suspicion of an invasive fungal infection. A precise early diagnosis may allow successful, specific antifungal therapy to be instituted.
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PMID:Acute Pancoast's syndrome caused by fungal infection. 305 66


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