Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of the study was to enhance the efficiency of early diagnosis of orbital phlegmon, by examining its clinical picture and using instrumental studies. Sixty-three patients with orbital phlegmon were treated at hospital in 1985 to 2007. Its diagnosis employed ultrasound and X-ray studies. Orbital phlegmon was diagnosed in 30 patients with orbital injury and 33 patients with inflammatory diseases of the eyelids, face, nasal sinuses, and infection metastasis from septic foci. The disease was characterized by intoxication syndrome, eyelid inflammatory changes, chemosis, exophthalmos, and ophthalmoplegia. The following complications: neuritis, optic nerve ischemia, meningoencephalitis, brain abscess, cavernous sinus thrombosis, and sepsis were observed. Ultrasound and X-ray (computed tomography, magnetic resonance imaging) studies provide the diagnosis of the disease in early periods and timely medical and surgical treatments.
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PMID:[Orbital phlegmon: clinical picture, diagnosis]. 1920

Human parechovirus-3 (HPeV-3) is an emerging pathogen that has been described as a cause of neonatal sepsis. Human parechoviruses are a family of viruses closely related to enteroviruses; however, enteroviral PCR will not detect HPeVs. We present clinical details of neonatal meningoencephalitis and hepatitis-coagulopathy syndrome caused by HPeV-3 infection.
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PMID:Human parechovirus-3 infection: emerging pathogen in neonatal sepsis. 1948 24

Listeria monocytogenes infection affects people throughout the all world, most often causing gastrointestinal disturbances, less inflammation of the central nervous system (meningitis, meningoencephalitis, absceses), sepsis, endocarditis and dispersed focal inflammation. Listeria monocytogenes infection in pregnant woman can lead also to premature birth or abortion. Listeriosis is a serious problem because of the high mortality in case of generalized infection, which can reach up to 20%. Listeria strains could be identified by determination of biochemical features--characteristic for each Listeria species. Biochemically identified strains could be serotyped using Seeliger method. Many authors developed a molecular biology-based methods of Listeria serotype determination The Doumith's method divide all Listeria monocytogenes serotypes for five genoserogroups. The purpose of this study was to determine the genoserogroups of Listeria monocytogenes strains and compare those results with results obtained by classical serotyping by Seeliger method. To this work 90 Listeria strains were used: 75 Listeria monocytogenes strains from clinical, food and environmental samples and 15 reference strains from Pasteur Institute collection and National Institute of Public Health--National Institute of Hygiene collection. All strains were serotyped using liquid stable antisera for determination of O and H Listeria monocytogenes antigens (Mast Diagnostic, UK). Multiplex PCR for Listeria monocytogenes serovars differentiation were performed according to Doumith et al procedure. The genoserogroup obtained from multiplex PCR of 10 Listeria monocytogenes reference strains were compatible with real serotype. In case of non-Listeria monocytogenes reference strains in multiplex-PCR, they were identified as non-monocytogenes. In group of 75 non-reference strains isolated from human, food and environmental sources, 34 belonged to genoserogroup I.1, two strains to genoserogroup I.2, 11 strains to genoserogroup II.1, 21 strains belonged to genoserogroup II.2 and 9 strains to genoserogroup III.
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PMID:[Genoserotyping of Listeria monocytogenes in multiplex PCR]. 1951 17

A 48-years-old man presented with slowly progressive bradykinesia, personality change and rapidly progressive left hemiparesis. On admission, he presented dementia, poor judgment, left hemiparesis. MRI revealed a widespread high intensity area in right hemisphere and MRA was almost normal. Serological tests of serum and CSF demonstrated high titers of antibodies to Treponema pallidum. He was treated for syphilis with daily penicillin injections without improvement. He died of sepsis eight months after admission. At autopsy, the brain weighed 1,100 g and the right cerebral hemisphere was atrophic, especially in frontal base, temporal, parietal, angular, and posterior regions covered by thickened, fibrotic leptomeninges. Microscopically, chronic meningoencephalitis was observed. Severe neuronal loss with gliosis was seen in the right cerebral cortices. Scattered rod-shaped microglia and inflammatory cell infiltration were visible in the cerebral parenchyma. The dorsal column of the spinal cord was not involved and meningovascular syphilis was unclear. The distribution of the encephalitic lesions was well correlated with the clinical and neuroradiological findings. This was a rare autopsy case presenting Lissauer's general paresis, clinically manifesting as rapidly progressive stroke-like episode.
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PMID:[Autopsy case of Lissauer's general paresis with rapidly progressive left hemiparesis]. 1961 44

Histophilus somni (Haemophilus somnus) is an important pathogen of cattle that is responsible for respiratory disease, septicemia, and systemic diseases such as thrombotic meningoencephalitis, myocarditis, and abortion. A variety of virulence factors have been identified in H. somni, including compositional and antigenic variation of the lipooligosaccharide (LOS). Phosphorylcholine (ChoP) has been identified as one of the components of H. somni LOS that undergoes antigenic variation. In this study, five genes (lic1ABCD(Hs) and glpQ) with homology to genes responsible for ChoP expression in Haemophilus influenzae LOS were identified in the H. somni genome. An H. somni open reading frame (ORF) with homology to H. influenzae lic1A (lic1A(Hi)) contained a variable number of tandem repeats (VNTR). However, whereas the tetranucleotide repeat 5'-CAAT-3' is present in lic1A(Hi), the VNTR in H. somni lic1A (lic1A(Hs)) consisted of 5'-AACC-3'. Due to the propensity of VNTR to vary during replication and cause the ORF to shift in and out of frame with the upstream start codon, the VNTR were deleted from lic1A(Hs) to maintain the gene constitutively on. This construct was cloned into Escherichia coli, and functional enzyme assays confirmed that lic1A(Hs) encoded a choline kinase, and that the VNTR were not required for expression of a functional gene product. Variation in the number of VNTR in lic1A(Hs) correlated with antigenic variation of ChoP expression in H. somni strain 124P. However, antigenic variation of ChoP expression in strain 738 predominately occurred through variable extension/truncation of the LOS outer core. These results indicated that the lic1(Hs) genes controlled expression of ChoP on the LOS, but that in H. somni there are two potential mechanisms that account for antigenic variation of ChoP.
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PMID:Molecular characterization of phosphorylcholine expression on the lipooligosaccharide of Histophilus somni. 1968 67

Mycobacterium mucogenicum is rarely associated to human infections. However, in the last year, a few reports of sepsis and fatal cases of central nervous systems have been documented. Here we report a fatal case of granulomatous meningoencephalitis of three weeks of evolution where DNA from a M. mucogenicum-like microorganism was identified postmortem in samples of brain tissue.
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PMID:Fatal granulomatous meningoencephalitis associated to mycobacterium mucogenicum-like microorganism: a case report. 1971 22

Streptococcus agalactiae (Lancefield group B; GBS) is a pathogen that causes meningoencephalitis in fish, mastitis in cows, and neonatal sepsis in humans. The objective of this study was to characterize S. agalactiae isolated from fish (n=27), cows (n=9), and humans (n=10) using pulsed-field gel electrophoresis (PFGE) and to investigate the virulence of the identified strains in Nile tilapia (Oreochromis niloticus). The PFGE types were determined by dendogram analyses and the in vivo virulence was evaluated by experimental infection (using i.p. and immersion routes) of Nile tilapia. Among the fish strains, 5 different PFGE patterns were observed and 21 strains showed the same genetic pattern. In some farms two or three profiles occurred simultaneously. The bovine and human strains exhibited high genetic diversity and few relationships were established among S. agalactiae strains from the three host origins analyzed. Eight S. agalactiae strains from fish caused high mortality of Nile tilapia. Three bovine strains infected Nile tilapia (by i.p. route) and two of those strains caused clinical signs of meningoencephalitis. All human strains (n=5) infected Nile tilapia (by i.p. route) and meningoencephalitis was induced by one strain (by both i.p. and immersion routes). In conclusion, the analyzed strains from the three natural hosts did not show genetic relatedness, yet some of the bovine and human strains were able to infect fish and cause meningoencephalitis. We suggest that genetic linkage is not a prerequisite for S. agalactiae to cross the host-specific barrier.
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PMID:Genotyping of Streptococcus agalactiae strains isolated from fish, human and cattle and their virulence potential in Nile tilapia. 1972 42

Lesions of meningoencephalitis were found in 55 per cent of 372 rabbits comprising the laboratory stock regarded as healthy, others with snuffles or dying from different affections while being kept under observation, and still others which were employed for experimental purposes, such as tumor transplantation and Treponema pallidum inoculation. None was injected intracerebrally. The lesions consist in the main of infiltration with mononuclear cells occurring around the blood vessels, in the meninges, in the cortex, and under the ependyma of the lateral ventricles, together with particular focal necrotic areas in the cortex. The incidence of these histopathological changes varies in different series of animals; in those supposedly normal and in rabbits inoculated with a transplantable tumor or with Treponema pallidum material, the percentage of positives was from 40 to 60; in those suffering from miscellaneous diseases, such as pneumonia, septicemia, etc., the percentage was 70, and in rabbits ill with snuffles, as many as 76 per cent were affected. Marked lesions were observed in 47.5 per cent of the total. The histopathological picture observed in these rabbits corresponds to those offered by a number of investigators as evidence of the transmission of certain nervous diseases of man to this animal. The accidental cerebral lesions in the rabbit, of a wide variety, and of frequent occurrence, are to be regarded as existing before any experimental procedure is begun. Their recognition is of the utmost importance in the interpretation of experimental results based on the presence of similar changes in this animal.
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PMID:BRAIN LESIONS OF THE DOMESTIC RABBIT. 1986 34

It is the opinion of Bull, that the streptococci recovered from poliomyelitic tissues, while having no etiological or pathological relationship to the virus of poliomyelitis, occur as secondary invaders in the disease. Smillie and Amoss indicated that the bacteria may be agonal invaders. The results of the experiments reported in this paper point to another source of the streptococci. They occur as contaminants which are introduced into the cultures during the process of grinding tissues. The source of the streptococcus may therefore be the air of the place in which the cultures are made. We have come to this conclusion because first, the tissues of which cultures yielded streptococci were derived from a number of monkeys with experimental poliomyelitis still in a vigorous state. Secondly, when the tissues were ground bacteria were noted much more frequently in their cultures than in those in which fragments of the same brains were used. Thirdly, microorganisms occurred more often in cultures made in the routine laboratory than in a special room where asepsis was carried to the extreme of a major surgical operation on man. Fourthly, streptococci were obtained from the air of the places where cultures were made. Finally, there is no correlation between the cultures of two portions of the same brain. The streptococci occurred in some cultures in pure growth and in others admixed with other ordinary species of bacteria. The latter were often found, in turn, in pure culture and what applies to streptococci, as mentioned in the preceding paragraph, applies equally to the staphylococci, diphtheroids, spore-bearing rods, and other miscellaneous, familiar microorganisms. We could not determine that there exists any etiological relation of the streptococci to poliomyelitis. The fermentation reactions of the microorganisms obtained from the air, from non-poliomyelitic and poliomyelitic monkey brains indicate that bacteria from any of these sources are markedly different. So also with the serological reactions of agglutination and precipitation. Furthermore no agglutination was observed when the serum of monkeys convalescent from experimental poliomyelitis was mixed with any of the streptococci recovered or those received directly or indirectly from Rosenow. Moreover, the intracerebral injection with cultures, irrespective of their source, induced in rabbits a purulent type of meningoencephalitis, often associated with streptococcic septicemia. This result is at marked variance with any known effects of the true filtrable virus of poliomyelitis in man and in the monkey.
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PMID:THE ROLE OF STREPTOCOCCI IN EXPERIMENTAL POLIOMYELITIS OF THE MONKEY. 1986 96

The authors describe a clinical case regarding a young female patient affected by sepsis due to methicillin-resistant Staphylococcus aureus (MRSA), associated to meningoencephalitis and cerebral abscess. The patient had no contact with hospitals in the months prior to illness and had always been healthy. She recovered thanks to linezolid therapy. The MRSA strain proved positive for Panton-Valentine leukocidin (PVL positive) and was therefore defined as community-acquired MRSA (CA-MRSA).
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PMID:[A case of community-acquired MRSA (CA-MRSA) sepsis complicated by meningoencephalitis and cerebral abscess, successfully treated with linezolid]. 2004 6


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