Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the present study is, to describe the morbidity and mortality of 196 patients with an acute abdominal condition who underwent surgery at the Department of Gynecology and Obstetrics of the TU Munich between 1982 and 1986. This is a percentage of 2.7 of all 7,167 operations carried out during this period. 118 of these patients had an extrauterine pregnancy and were therefore excluded from the study. The second group of 79 patients, mostly with inflammatory diseases, were analyzed. In most of these cases the acute abdominal condition was caused by a tuboovarian abscess (48.1%), followed by peritonitis because of a bowel-disease (11.4%). 6 patients suffered from an abscessing endometritis due to a caesarean section with sepsis in 5 cases. A generalized peritonitis occurred in 5 cases and was treated with a planned relaparatomy with lavage. 63% of the patients had no complications within 28 days after operation, 13% developed a subileus; in 7% a relaparatomy was necessary. 6% of the patients had problems of wound-healing. One patient with stomach-cancer died 3 weeks after the operation because of a fulminant lung-embolism. Thus the mortality rate was 1.5%. A further 27% were treated at the intensive care-unit and 18% needed artificial respiration. The average postoperative period of hospitalisation was 15 days. In comparison, patients with elective operations remained 13 days. The morbidity and mortality of patients due to surgery of an acute abdominal condition was relatively small; postoperative complications could be well treated in all cases and is probably the result of a positive and early indication for surgical intervention.
 ...
PMID:[Acute abdomen in gynecology]. 318 9

Because of the high incidence of beta-lactamase production among bacteria that are found commonly in pelvic infections in women, beta-lactamase-inhibiting antibiotics should prove effective in treating those infections. In a randomized, comparative study of 47 women with intraabdominal infections, 23 received ticarcillin disodium/clavulanate potassium, and 24 received cefoxitin. Among the infections treated were endometritis, pelvic inflammatory disease, amnionitis, salpingitis, septicemia, intraabdominal abscess and pelvic abscess. The bacteriologic response to ticarcillin disodium/clavulanate potassium was 88.8% success as compared with 87.5% for cefoxitin. Clinical cures were achieved in 98.8% of patients treated with ticarcillin disodium/clavulanate potassium and 90.9% of patients treated with cefoxitin. The adverse reactions were diarrhea, transient eosinophilia and transient thrombocytosis.
 ...
PMID:Infection in women. Clinical experience with beta-lactamase inhibitors. 329 5

Decreases in plasma fibronectin levels following surgery and subsequent to trauma and sepsis have been previously reported. There have been no reports, however, regarding plasma fibronectin levels following cesarean section. Plasma fibronectin levels were followed for 3 days postpartum in 49 patients including cesarean section control patients, patients with cephalopelvic disproportion, pregnancy-induced hypertension, and endometritis. Cesarean section and cephalopelvic disproportion were not associated with a change in postpartum fibronectin levels. Pregnancy-induced hypertension and endometritis did show a significant increase (p less than 0.05) in plasma fibronectin levels. These levels are probably not decreased because of the large fibronectin pool in these otherwise healthy women.
 ...
PMID:Postcesarean section plasma fibronectin levels. 334 22

In a study of 312 women with acute chorioamnionitis, 152 women received antibiotics before delivery, 90 received antibiotics after cord clamping, and 70 did not receive antibiotics. Antibiotics were administered during labor rather than after cord clamping if delivery was not imminent. Although endometritis developed more frequently in the patients receiving antibiotics after cord clamping, the difference was not statistically significant (5.6% versus 3.9%, difference not significant). There were two cases of verified sepsis in the group of infants (35 weeks) born to mothers receiving intrapartum antibiotics and there were eight cases in the no antibiotics group (p = 0.06). More importantly, in neonates greater than or equal to 35 weeks' gestational age, there was a significant difference in the frequency of positive blood cultures for group B streptococci (0/133 versus 8/140, p less than 0.05). We conclude that administration of antibiotics to the mother during labor may result in a decreased incidence of neonatal sepsis.
 ...
PMID:Intrapartum treatment of acute chorioamnionitis: impact on neonatal sepsis. 342 Dec 56

Microflora of pathological biosubstrates from 25 patients aged from 18 to 41 years with criminal abortion complications such as sepsis, septic shock, septicemia, and septic pyemia, peritonitis and endometritis of various severity was studied. Obligate anaerobic organisms in association with facultative anaerobes were detected in 84 per cent of the patients. Bacteroids were isolated from operation materials of 36 per cent of the patients. Bacteroids in association with Staphylococcus aureus, peptostreptococci and enterococci were recorded in 16, 8 and 24 per cent of the patients, respectively. Composition of the anaerobic and facultative anaerobic microflora was analyzed in the patients with local and general infections. Antibiotic sensitivity assay of the bacteroids showed that rifampicin, metronidazole, levomycetin (chloramphenicol) and clindamycin were the most active drugs. The use of anaerobic techniques enabled to demonstrate that in patients with purulent septic complications of criminal abortion there prevailed anaerobic-aerobic associations. The results should be considered in treatment of gynecological patients with purulent septic infections.
 ...
PMID:[Anaerobic microflora of patients with suppurative and septic complications after non-hospital abortions]. 343 93

Certain infections, such as UTI, may have an increased incidence during pregnancy owing to physiological changes. Between 2 and 10% of pregnant women have covert or asymptomatic bacteriuria which is associated with an increased incidence of acute symptomatic UTI in later pregnancy if left untreated. Thus antenatal screening to detect the presence of bacteriuria is justified. Most women will remain abacteriuric throughout the remainder of pregnancy after a single course of antibiotic therapy but a small percentage will fail to respond or have recurrent UTIs. Maternal infection with certain organisms, namely those which resist phagocytosis, may result in transplacental infection of the fetus in utero. Congenital syphilis is preventable and antenatal serological screening is usually routinely performed. Listeriosis following maternal infection in pregnancy is less predictable and the epidemiology of L. monocytogenes remains unclear. Genital tract carriage of sexually transmitted organisms, such as N. gonorrhoeae or C. trachomatis, may also be detected during pregnancy and antibiotic therapy will be indicated to eradicate such organisms and prevent maternal and neonatal morbidity. Antibiotic therapy during pregnancy will not, however, eradicate carriage of GBS from the genital tract, although carriage status at term can now be reliably predicted by using enriched culture techniques and swabbing multiple sites on more than one occasion. Where carriage is confirmed, the administration of intrapartum antibiotics to the mother appears a useful approach in the prevention of early onset neonatal GBS disease. Broad spectrum intrapartum antibiotics may also be indicated when there are complications, such as prolonged labour or premature rupture of membranes, which are associated with a higher incidence of maternal postpartum endometritis and morbidity than in women following uncomplicated vaginal delivery. Serious postnatal sepsis and shock is fortunately now rare. The pharmacokinetics of antibiotics in late pregnancy and the puerperium are altered and maternal serum levels may be reduced by 10-50%. Most antibiotics cross the placenta and are excreted in breast milk. Some agents, such as the beta-lactams, are considered safe in pregnancy and breast-feeding women while other antibiotics are contraindicated owing to risk of toxicity (often rare) or teratogenicity (often theoretical). Caution is necessary with many agents which may cause side effects or toxicity although this does not necessarily contraindicate their use in pregnancy.(ABSTRACT TRUNCATED AT 400 WORDS)
 ...
PMID:Prescribing in pregnancy. Bacterial infections in pregnancy. 352 53

The purpose of this prospective investigation was to determine the incidence of subclinical intra-amniotic infection in asymptomatic patients who had intact membranes and refractory preterm labor. Refractory preterm labor was defined as persistent uterine contractions despite maximum recommended doses of parenteral tocolytics, or recurrent preterm labor within three days of successful transition to oral tocolytics. Amniotic fluid was cultured aerobically and anaerobically and prepared for Gram stain and group B streptococci latex fixation test. One of 24 women had a positive latex fixation test, but the culture was negative. One culture was positive for isolated colonies of Corynebacterium sp. None of the patients developed clinical evidence of intra-amniotic infection or postpartum endometritis. The mean prolongation of pregnancy was 31 days (range 1-63). None of the infants had evidence of sepsis in the immediate neonatal period. In this population, subclinical infection was an uncommon cause of refractory preterm labor.
 ...
PMID:Subclinical intra-amniotic infection in asymptomatic patients with refractory preterm labor. 357 2

A disease consisting of suppurative endometritis, salpingitis, perioophoritis and/or peritonitis has been an important problem in aging B6C3F1 mice on some chronic chemical carcinogenicity studies. Klebsiella oxytoca was identified as the most likely causative agent based on cultural isolations from lesions. A study was done to determine prevalence of K. oxytoca in the "normal" flora of mice from different breeding facilities. In a survey of 684 retired female breeder mice from 10 National Institutes of Environmental Health Sciences (NIEHS) and National Cancer Institute (NCI) production facilities, K. oxytoca was isolated from only 1% of nasopharynxes, vaginas and ceca in mice from 7 of 10 facilities. Epizootiology of the natural infection was investigated using the capsular and biochemical typing methods on 97 isolates of K. oxytoca from mice of 11 NIEHS and NCI production facilities and sentinel mice from three National Toxicology Program testing facilities. A few capsular types were associated with either lesions, nonlesion isolation sites, or certain facilities but the capsular typing method was not reproducible. No associations were found for any biotypes. A K. oxytoca isolate (capsular type 20, biotype A) from a typical case of perioophoritis was used in attempts to reproduce the natural disease in Klebsiella-free B6C3F1 female mice. Mice were inoculated at 6 months of age by the intravaginal, intrauterine or intraperitoneal route with one of four doses of K. oxytoca and killed at 4, 7 or 10 months post-infection. Some mice given high doses (10(6) or 10(8) colony forming units) of K. +oxytoca died of septicemia and a few developed mild inflammatory lesions in the uterus.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:The role of Klebsiella oxytoca in utero-ovarian infection of B6C3F1 mice. 359 83

Characteristic features of expert evaluation of temporary disability during pregnancy and after abortion and labor adopted in the USSR are outlined. At the earliest stages of pregnancy, women should be assigned to the work not associated with potential exposure to hazardous factors. Women with pregnancy complications should undergo comprehensive examination, preferably in a hospital setting: average length of stay is 20 days for threatened abortion, 21 days for premature labor (28-37-week pregnancy), 16 days for hypertension, 14 days for vomiting or nephropathy, 17 days for anemia, and 14 days for Rhesus-incompatibility. After abortion on demand or abortion for medical indications, a woman should be given a sick leave. The length of sick leave depends upon the pregnancy term (56 days for pregnancy longer than 28 weeks). Women with normal pregnancy and labor can receive a leave for 112 calendar days (56 days during the prelabor period and 56 days for the postpartum period). In the case of labor complications or multiple pregnancy, duration of the postpartum leave should be increased to 70 days. Indications for a 70-day postpartum leave include preeclampsia or eclampsia; cesarean section or vacuum-extraction; profuse hemorrhage during labor requiring blood transfusions; tears of the cervix uteri; postpartum endometritis, thrombophlebitis, septicemia, and suppurative mastitis; history of heart valve disease or congenital heart defects; and premature labor.
 ...
PMID:[Expert evaluation of temporary disability with regard to pregnancy, abortion and labor]. 368 64

The frequency of postoperative infections after cesarean section was studied during two periods. In the first period no strict preoperative hygienic routines were applied; 321 patients were delivered by cesarean section during this period. In the next period strict hygienic routines were introduced; this period included 337 patients. The infection rate was significantly reduced during the second period from 20% to 16%. This reduction was found among the elective operations, and among parturients who had been treated in the hospital for more than 24 h prior to delivery. The frequency of endometritis decreased significantly from the first to the second period, whereas no difference was found concerning wound infections. Significantly fewer patients contracted septicemia during the second period. Since all septicemia cases occurred in endometritis patients the results might indicate that not only the number of patients contracting infection but also the severity of the infections was reduced. No reduction of infections was found after emergency operations. Antibiotic prophylaxis might therefore be of value in this group of patients.
 ...
PMID:Effect of a strict preoperative hygienic routine on the rate of infections following cesarean section. 381 60


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>