Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Non 0-1 Vibrio cholerae infection is often associated with ingestion of contaminated seafood and its common presentation is gastroenteritis. Septicemia may be found in immunocompromised hosts resulting in mortality approaching 50%. A case is reported of non 0-1 Vibrio cholerae infection presenting with septicemia in a patient with neutrocytic ascites suggestive of spontaneous bacterial peritonitis.
 ...
PMID:Non 0-1 Vibrio cholerae septicemia and culture negative neutrocytic ascites in a patient with chronic liver disease. 779 72

From May 21 to June 4, 1993, a collaborative training project involving U.S. Army veterinary personnel, the Lao-American Integrated Rural Development Project, and the Lao Department of Livestock and Veterinary Services occurred in the Houa Muang District of Houa Phan Province in northeastern Laos. The project focus was control of the major animal diseases of economic or public health importance in the area to include, but not limited to, hemorrhagic septicemia, anthrax, swine fever (hog cholera), and Newcastle disease. The project provided Lao veterinary personnel and villagers with didactic training and field demonstrations in disease control practices. Supplies and equipment necessary to continue disease control activities were provided to the district at the conclusion of the training and field demonstrations. The project was designed to be compatible with disease reporting and surveillance systems at district, province, and national levels and be exportable to other districts and provinces. In addition to disease-control efforts, blood and fecal parasite surveys were conducted.
 ...
PMID:Lao People's Democratic Republic Veterinary Public Health Project. 787 Mar 20

A 58-year-old man with diabetes had fever and chills 5 days after ingestion of raw seafood. Nausea, vomiting, watery diarrhea, bilateral calf pain, and neck stiffness subsequently developed. Generalized edema and ecchymotic patches with a vesiculobullous eruption appeared on the extremities. Four blood cultures were positive for Vibrio cholerae non-01. The patient was successfully treated with antibiotics. This is the first documented case of V. cholerae non-01 septicemia with cutaneous lesions and meningitis in Taiwan.
 ...
PMID:Cutaneous manifestations of non-01 Vibrio cholerae septicemia with gastroenteritis and meningitis. 815 89

Bullous lesions associated with non-01 Vibrio cholerae developed in a patient with hepatic cirrhosis who had recently ingested raw oysters. He died of overwhelming sepsis despite 5 days of aggressive antibiotic therapy. Non-01 V. cholerae was isolated from blood, peritoneal fluid, and bullae. The organism produced a cytotoxic factor that destroyed Chinese hamster ovary cells. Although septicemia caused by non-01 V. cholerae is uncommon, cutaneous manifestations of this organism are even rarer. Our patient represents the first reported case of bullous lesions associated with non-01 V. cholerae septicemia.
 ...
PMID:Fatal septicemia and bullae caused by non-01 Vibrio cholerae. 840 40

We describe septicemia due to Vibrio cholerae 0139 Bengal, the newly described causative agent of cholera, in a child who also had simultaneous intestinal infection with Shigella boydii. Because V. cholerae 0139 is capsulated, its propensity to cause extraintestinal infection is stressed.
 ...
PMID:Septicemia due to Vibrio cholerae 0139 Bengal. 858 39

We describe a patient with non-O1, non-O139 Vibrio cholerae septicemia associated with hemorrhagic bullous skin lesions of the lower extremities. The patient had underlying liver disease, and he probably acquired the organism through ingestion of raw clams. Although his condition rapidly improved during appropriate therapy, the patient's cellulitis and skin lesions persisted and he developed a fluid collection of the lower extremity that required drainage. Molecular methods were used to examine the non-O1 V. cholerae isolate for several known virulence factors of V. cholerae O1. The isolate failed to express cholera toxin and toxin-coregulated pilus (Tcp) and was negative in Southern hybridizations for ctxB, tcpA, toxR, and toxT. The vast majority of vibrio infections in the United States are clustered in the Gulf Coast area. This patient acquired the infection on Cape Cod. To our knowledge, this is the first case of non-O1 V. cholerae septicemia reported to have occurred in Massachusetts. Given the high fatality rate of this infection, it is important for physicians to consider this diagnosis in patients who have underlying risk factors and appropriate epidemiologic exposures, even when they reside as far north as the New England states.
 ...
PMID:Primary septicemia caused by Vibrio cholerae non-O1 acquired on Cape Cod, Massachusetts. 858 71

Previous studies from our laboratory have implicated a role for Ca2+ in prostaglandin E2 (PGE2)-induced suppression in T-cell proliferation during sepsis. The present study further elucidated the mechanism of PGE2-induced suppression in T-cell proliferation. We assessed whether prevention of the suppression in Ca2+ mobilization in PGE2-treated T-cells would restore proliferation. Rat splenic T-cell Ca2+ mobilization and proliferation were measured after stimulation of cells with concanavalin A (Con A) employing Fura-2 spectroscopy and cellular [3H]thymidine uptake techniques, respectively. PGE2 and other agents that directly up-regulate the PGE2-mediated cell signaling events (e.g., cholera toxin and forskolin), substantially suppressed both Con A-induced proliferation (p < .01) and Ca2+ mobilization in T-cells (p < .01). When stimulated with Con A plus ionomycin, [Ca2+]i in PGE2 treated T-cells (395 +/- 21, nM) was not significantly different (p > .05) from that observed in Con A-stimulated T-cells without the PGE2 exposure (351 +/- 8.6). The stimulation of PGE2-treated T-cells with ionomycin and Con A also significantly (p < .025), if not completely, prevented the PGE2-induced suppression in T-cell proliferation. These results suggest that the cross-talk between the TCR- and PGE2-mediated signaling in T-cells negatively modulates the TCR signals at the Ca2+ mobilization step and/or earlier to it.
 ...
PMID:Calcium signaling restitution prevents T-cell proliferative suppression by prostaglandin E2. 885 43

A retrospective review of cases seen in the Diarrhea Treatment and Training Unit (DTU) of Bangalore (India) Medical College's Vani Vilas Children's Hospital during 1992-1994 confirmed the efficacy of the standard case management approach. This strategy entails oral rehydration therapy (ORT), continued feeding, and selective use of intravenous fluids and antibiotics. Of the 7966 children (4374 males and 3592 females) reporting to the DTU during the 2-year study period, only 2412 (30.5%) had received oral rehydration solution (ORS) or home-available fluids before admission. Acute watery diarrhea was present in 7316 cases (91.84%). Death occurred in 59 acute watery diarrhea cases, 6 dysentery cases, and 7 persistent diarrhea cases. The average time for cases managed in the ORT area was 2 hours and 45 minutes, while the hospital stay for admitted cases averaged 3 days. In 6957 cases (87.33%), ORS was sufficient treatment. Of the 1009 children (12.67%) who required intravenous fluids, 254 had dehydration attributable to conditions such as persistent vomiting and inability to drink due to oral thrush. Only the 512 children (6.2%) with cholera and dysentery received antibiotics. Of the 72 children who died (case fatality rate, 0.9%), 43 had associated severe malnutrition with pneumonia and anemia, 14 had a central nervous system infection, and 13 had septicemia; in only 2 cases could death be directly ascribed to diarrheal disease. One of these cases was due to shigella encephalopathy and the other to severe dehydration with acidosis. The average cost of treatment per patient was Rs 2.91 when only ORS was used compared with Rs 24.28 when intravenous rehydration was required. The finding that less than one-third of children had received ORS before admission suggests a need for the establishment of more DTUs in large hospitals that can train community-based health personnel in diarrhea case management.
 ...
PMID:Management of diarrhea in a DTU. 905 85

Several case reports attest to the pathogenicity of Pasteurella multocida in raptors; however, the pathologic syndromes have not been fully described. We describe here the lesions encountered in 22 avian cholera cases in raptors. Besides septicemia-related lesions, a unique syndrome of esophageal abscesses was noted in 8 of the 11 (73%) Buteo hawks that succumbed to avian cholera. Esophageal abscesses were not noted in birds belonging to the order Strigiformes (owls) or family Falconidae (falcons and their relatives). Thus, the presence of white plaques in both the oropharynx and esophagus of Buteo hawks may indicate a possible P. multocida infection and should be considered in the differential diagnosis. This study also documents the first cases of avian cholera in a rough-legged hawk (Buteo lagopus) and a flammulated owl (Otus flammeolus).
 ...
PMID:Lesions associated with Pasteurella multocida infection in raptors. 908 38

We describe a patient with a non-0:1, non-0:139 Vibrio cholerae septicemia associated with ecythema gangrenosa-like skin lesions. The patient acquired the infection in Puerto Rico. Given the high fatality rate, it is important for the medical community to consider the diagnosis in high risk patients with exposures in Puerto Rico tropical waters.
 ...
PMID:Septicemia due to a non-0:1, non-0:139 Vibrio cholerae. 916 34


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>