Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036572 (seizures)
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Human Gene/Protein
CUB domain-containing protein 2 8.6
CASKIN1 8.6
STFB 8.6
retinoic acid early transcript 1E 8.6
methyl-CpG binding domain protein 5 8.6
solute carrier family 25, member 12 8.6
SEZ6L2 protein 8.6
MPDZ protein 8.6
hypothetical protein DKFZp566A1524 8.6
C17orf63 8.6
SEZ6L protein 8.6
glutamate receptor, ionotropic, N-methyl D-aspartate 1 8.6
phosphatidylinositol glycan class S 8.6
CCDC88C protein 8.6
GDP-mannose pyrophosphorylase A 8.6
Myosin XVIIIB 8.6
Chromodomain-helicase-DNA-binding protein 2 8.6
chromosome X open reading frame 59 8.6
LYSMD3 8.6
ceroid-lipofuscinosis, neuronal 5 8.6
transmembrane protein 25 8.6
zinc finger protein 852 8.6
JRK protein 8.6
LOC442459 8.6
GNAO1 protein 8.6
Voltage-gated sodium channel alpha subunit 8.6
Histone H2B type 1-H 8.6
N-ethylmaleimide-sensitive factor attachment protein, beta 8.6
WDR37 protein 8.6
sodium activated potassium channel 8.6
SEZ6L2 8.4
SMEI 8.2
MTMR10 8.0
KPTN 8.0
SCN1A 8.0
PIGP 7.9
TBC1D24 7.8
GABRG2 7.8
PCDH19 7.8
KCNT1 7.8
protocadherin 19 7.7
antiquitin 7.7
AP3M2 7.6
PROSC 7.6
G1/S-specific cyclin E2 7.6
QARS protein 7.6
SCN1B 7.6
PIGK 7.6
PNKP protein 7.6
NEDD4L variant 7.6
HHMJG 7.6
F-box and leucine-rich repeat protein 20 7.6
GHBR 7.6
transmembrane and tetratricopeptide repeat containing 3 7.6
ISSX 7.6
asparagine-linked glycosylation 13 homolog 7.6
Chloride intracellular channel 2 7.6
KIAA1328 7.6
GABRA2 protein 7.6
Rho GTPase activating protein 2 7.6
FMN2 protein 7.6
SCNB1 7.6
DMXL2 protein 7.6
PRG-5 7.6
Syntaxin binding protein 1 7.6
beta B3 crystallin 7.6
COPS4 7.6
MOCS1B protein 7.6
Ataxin 10 7.6
PIGQ 7.6
PIGT 7.6
OTUD7A 7.5
Proline-rich transmembrane protein 2 7.5
JH8 7.5
ADLTE 7.5
SCN8A 7.4
AP3D1 7.4
TMTC3 7.4
RARS2 7.4
SEZ-6 7.4
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Disease
Cerebral lipidosis 8.6
Refractory frontal lobe epilepsy 8.6
Writing epilepsy 8.6
Excessive masturbation 8.6
Mental dullness 8.6
Rheumatic myocarditis 8.6
Familial epilepsy 8.6
Meningeal tuberculoma 8.6
Myoclonic astatic epilepsy 8.6
Bacterial encephalitis 8.6
Nodding spasm 8.6
Hutterite cerebro-osteo-nephrodysplasia 8.6
Kohlschutter syndrome 8.6
Human herpesvirus 6 infection 8.6
RESDX 8.6
Hallucinations of music 8.6
absence of status epilepticus 8.6
monosomy 20q 8.6
Atypical absence seizures 8.6
Sleep starts 8.6
Temporal encephalocele 8.6
Jamestown Canyon virus encephalitis 8.6
FEB5 8.6
CDG Id 8.6
Childhood epilepsy with occipital paroxysms 8.6
Hypogammaglobulinemic sprue 8.6
D-Glyceric aciduria 8.6
BFIC2 8.6
CDG Im 8.6
Hypotonic cerebral palsy 8.6
Neonatal hypoparathyroidism 8.6
oneirophrenia 8.6
Myelomonocytic Leukemia 8.6
Cingulate epilepsy 8.6
Simple partial status epilepticus 8.6
Pure photosensitive epilepsy 8.6
FEB4 8.6
epilepsy; symptomatic 8.6
Simple partial seizures 8.6
FEB6 8.6
BFNIS 8.6
Intractable occipital lobe epilepsy 8.6
Pseudoprecocious puberty 8.6
CDG Ik 8.6
Erythropoietic coproporphyria 8.6
Semilobar holoprosencephaly 8.6
Benign focal epilepsy of childhood 8.6
Symptomatic West syndrome 8.6
Intrapartum eclampsia 8.6
Confusional migraine 8.6
MRX14 8.6
Acute bronchiolitis due to respiratory syncytial virus (RSV) 8.6
dermotrichic syndrome 8.6
Bathing epilepsy 8.6
Proud syndrome 8.6
Intermittent confusion 8.6
Catamenial epilepsy 8.6
Neonatal seizures 8.6
GEFS+ 8.6
Focal motor seizures 8.5
Eating epilepsy 8.5
FEB2 8.5
Clonic seizures 8.4
Benign myoclonic epilepsy in infancy 8.4
Gelastic epilepsy 8.4
FEB3 8.4
reflex epilepsy 8.4
Recurrent seizures 8.4
Musicogenic epilepsy 8.4
Secondarily generalized seizures 8.3
Benign neonatal seizures 8.3
Other epilepsy 8.3
Complex partial status epilepticus 8.3
WHSCR2 8.3
salaam seizures 8.3
Reading epilepsy 8.3
Generalized epilepsy 8.3
Idiopathic epilepsy 8.3
atonic seizure 8.2
Lennox-Gastaut syndrome 8.2
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Symptom
Clonic spasm 8.6
Decerebrate posture 8.6
Postictal headache 8.6
Convulsive movements 8.6
Antepartum eclampsia 8.6
Polyopsia 8.6
Stertorous breathing 8.6
seizures 8.6
Clonic movements 8.6
Hyposexuality 8.4
tonic seizure 8.4
partial seizure 8.2
Convulsive seizure 8.0
Todd's paralysis 8.0
tonic-clonic seizure 7.8
Nasal discomfort 7.6
Empty delta sign 7.6
Drop attacks 7.5
clonus 7.4
Negative myoclonus 7.2
Increased work of breathing 7.0
Pulmonary suppuration 7.0
Posturing 7.0
Marked rigidity 7.0
Facial grimacing 7.0
Action myoclonus 6.8
gustatory hallucination 6.6
Bruns nystagmus 6.6
abnormal head movement 6.6
Cardiac syncope 6.5
myoclonus 6.4
feeling of choking 6.3
Paroxysmal dystonia 6.3
Acquired stuttering 6.3
Dysdiadochokinesis 6.3
Visual phenomena 6.2
Brudzinski's sign 6.2
hypotonia 6.1
Postpartum headache 6.0
benign congenital hypotonia 6.0
heaviness of the head 6.0
waxy flexibility 6.0
carpopedal spasm 5.9
lipuria 5.8
Hyperekplexia 5.8
amimia 5.7
Lower extremity weakness 5.6
consciousness disturbance 5.5
meningism 5.5
Mental status changes 5.4
Kernig's sign 5.3
Olfactory hallucinations 5.3
Jitteriness 5.3
chest restriction 5.3
ataxia 5.2
asterixis 5.2
hemiplegia 5.2
decreased bowel sounds 5.2
hypertonia 5.2
visual hallucination 5.2
ataxic gait 5.1
lethargy 5.1
Neurologic symptoms 5.1
impaired motor coordination 5.0
Pyramidal signs 5.0
catatonia 5.0
neck stiffness 5.0
Opisthotonus 4.9
personality change 4.8
chorea 4.7
Thunderclap headache 4.7
penile discharge 4.7
twitching 4.7
musculoskeletal chest pain 4.6
disturbed speech 4.6
hemihypesthesia 4.6
sleepiness 4.6
prostration 4.6
hypnagogic hallucination 4.5
delayed language development 4.5
more...
Drug
Dimeray 8.6
Valproate semisodium 8.6
Fluzinamide 8.6
Ganaxolone 8.3
Rufinamide 8.3
Felbatol 8.3
Seletracetam 8.2
Ralitoline 8.2
Gabitril 8.1
Gabitril 8.1
Flurothyl 8.0
Remacemide hydrochloride 8.0
Zonegran 7.9
Keppra 7.9
Topamax 7.7
Liskantin 7.6
Iofetamine hydrochloride I 123 7.6
Progabide 7.5
Sulthiame 7.4
Stiripentol 7.4
Loreclezole 7.3
Carisbamate 7.2
Fosphenytoin 7.2
Methsuximide 7.1
Paregoric 7.0
Carbatrol 7.0
Adinazolam mesylate 7.0
Diastat 7.0
Kainic acid 6.9
Orphenadrine citrate 6.8
Disipal 6.8
Cerebyx 6.8
GVG 6.8
Sodium valproate 6.7
Phenytoin 6.7
Abecarnil 6.7
Amobarbital sodium 6.6
Molindone hydrochloride 6.6
Frisium 6.6
Oxaprozin 6.6
Zonisamide 6.6
Cloxazolam 6.5
Pilocarpine 6.3
Inversine 6.3
Conivaptan hydrochloride 6.3
Tranxene 6.1
Valproic Acid 6.1
Phenobarbital sodium 6.0
Brocresine 6.0
Halazepam 6.0
Ethyl loflazepate 6.0
Dilantin 6.0
Gabapentin 6.0
Tranxene 6.0
Fampridine 5.9
Magnesium sulfate 5.9
Cyclogyl 5.8
Nimetazepam 5.8
Serzone 5.8
Pipamperone 5.7
Bitrex 5.7
Inversine 5.6
Calcium hopantenate 5.6
Pregabalin 5.6
Physostigmine salicylate 5.5
Amoxapine 5.5
Dizocilpine maleate 5.5
Domoic Acid 5.5
Klonopin 5.5
Cyclogyl 5.5
Thalomid 5.5
C5H11NO2S 5.5
Flexeril 5.3
Dexamethasone palmitate 5.3
R-mephobarbital 5.3
Mifamurtide 5.3
Vitamin B 5.3
Methohexitone 5.3
7-Nitroindazole 5.2
Y-700 5.2
more...
Enzyme
phosphatidylinositol N-acetylglucosaminyltransferase 7.6
3-hydroxy-2-methylbutyryl-CoA dehydrogenase 7.0
leucine decarboxylase 6.3
PHT 6.1
XMT 6.0
branched-chain acyl-CoA dehydrogenase 5.9
palmitoyl-protein thioesterase 5.6
tripeptidyl peptidase 5.5
GABA transaminase 5.5
succinic semialdehyde dehydrogenase 5.4
guanidinoacetate methyltransferase 5.3
XMT 5.3
biotinidase 5.3
PdxH 5.3
3-hydroxyisobutyryl-CoA hydrolase 5.1
pterin-4alpha-carbinolamine dehydratase 5.0
mannosyl-oligosaccharide glucosidase 5.0
aspartate N-acetyltransferase 5.0
adenylosuccinate lyase 4.9
arginyl-tRNA synthetase 4.8
sulfite oxidase 4.8
aspartoacylase 4.8
EC 2.4.99.4 4.7
sulfite oxidase 4.7
6-pyruvoyltetrahydropterin synthase 4.7
3-hydroxyanthranilic acid oxygenase 4.7
phosphoglycerate dehydrogenase 4.6
tRNA isopentenyltransferase 4.5
phosphoserine aminotransferase 4.5
methylcrotonyl-CoA carboxylase 4.4
adenosine kinase 4.4
glutamate decarboxylase 4.4
serum carnosinase 4.4
pyridoxal kinase 4.3
glycine amidinotransferase 4.3
steroid 11beta-hydroxylase 4.2
kynurenine aminotransferase 4.2
phosphoserine phosphatase 4.2
BCKDH 4.1
5,10-methenyltetrahydrofolate synthetase 4.1
alkylglycerol monooxygenase 4.0
3-hydroxy-3-methylglutaryl-CoA lyase 3.9
T-protein 3.9
glutaryl-CoA dehydrogenase 3.9
PLP phosphatase 3.9
splicing endonuclease 3.8
DNA 3'-phosphatase 3.8
PME 3.7
neurosin 3.6
quinolinic acid phosphoribosyltransferase 3.5
selenocysteine lyase 3.5
triokinase 3.5
CTD kinase 3.5
spermine synthase 3.5
malonyl-CoA decarboxylase 3.4
sulfur dioxygenase 3.4
kynureninase 3.4
glutaminyl-tRNA synthetase 3.4
protein L-isoaspartyl methyltransferase 3.3
fucokinase 3.3
glycine decarboxylase 3.3
dihydroxyacetone phosphate acyltransferase 3.3
chondroitin 6-sulfotransferase 3.3
galactocerebrosidase 3.3
propionyl-CoA carboxylase 3.2
GM3 synthase 3.2
propionyl-CoA carboxylase 3.2
CPS 3.2
asparaginyl-tRNA synthetase 3.2
5alpha-reductase 3.2
5alpha-reductase 3.2
dihydropteridine reductase 3.1
histamine N-methyltransferase 3.1
isovaleryl-CoA dehydrogenase 3.1
kynurenine 3-monooxygenase 3.1
phosphomannomutase 3.1
arginyltransferase 3.0
1-acylglycerol-3-phosphate O-acyltransferase 3.0
pantothenate kinase 3.0
hydroxyprostaglandin dehydrogenase 3.0
more...
Compound
3-aminophenylphosphonic acid 8.6
Fluorofelbamate 8.6
N-(2-propylpentanoyl)urea 8.6
C15H22NO 8.6
Dimethyl glutarate 8.6
C15H22NO 8.6
2-propylcyclohexanone 8.6
octahydro-2(1H)-quinolinone 8.6
3-azaspiro[5.5]undecane-2,4-dione 8.6
3-hydroxy-isobutyryl-CoA 8.6
hexahydro-1H-isoindole-1,3(2H)-dione 8.6
1-acetyl-2-pyrrolidinone 8.6
2-chloro-N,N-diphenylacetamide 8.6
3-phenyl-3-buten-2-one 8.6
hexahydro-1H-isoindole-1,3(2H)-dione 8.6
2-chloro-3-hydrazinopyrazine 8.6
3,4-dichlorobenzamide 8.6
Phenylacetoacetonitrile 8.6
C15H22NO 8.6
2-azaspiro[4.5]decane-1,3-dione 8.4
Cinromide 8.2
1-dodecanoyl-2-pyrrolidinone 8.0
Levetiracetam 7.8
N-(2,6-dimethylphenyl)benzamide 7.8
2-phenyl-1,3-propanediol 7.7
Fosphenytoin 7.7
Felbamate 7.7
furo[3,4-b]pyridine-5,7-dione 7.6
SC-13504 7.6
LY201116 7.6
1-alkenyl-2-acyl-glycerophosphoethanolamine 7.6
N-Phenylphthalimide 7.6
Diethyl glutarate 7.6
Diethyl ethylmalonate 7.6
ethyl 2,2-diphenylpropanoate 7.6
Avizafone 7.6
C16H19NO4 7.6
1-amino-2-butanol 7.6
Cunaniol 7.6
N-methyl-2-phenylacetamide 7.6
Lactal 7.6
2-(diethylamino)acetamide 7.6
Phenylethylmalonamide 7.6
2-phenyl-2-butenenitrile 7.6
Pimprinine 7.6
Hygrine 7.6
strychnidin-10-one 7.6
Vigabatrin 7.6
Ethosuximide 7.5
Clobazam 7.5
2-azaspiro[4.4]nonane 7.5
Zonisamide 7.5
Oxcarbazepine 7.5
Tiagabine 7.4
Phensuximide 7.4
6,7-dimethoxy-3,4-dihydroisoquinoline 7.3
Valnoctamide 7.2
3-piperidinecarboxylic acid 7.2
Lamotrigine 7.1
Cefoselis 7.0
C15H15NO 7.0
4-ethylcyclohexanone 7.0
C5H10N2O 7.0
C13H15NO2 7.0
L-Guluronic acid 7.0
C16H17NO2 7.0
Urothione 7.0
Pheniramine maleate 7.0
Compound 84 7.0
Melianone 7.0
2-ethylcyclohexanone 7.0
6-chloro-1H-indole 7.0
diethyl pimelate 7.0
2-ethylcyclohexanone 7.0
1,3-dihydro-2H-imidazol-2-one 7.0
Elymoclavine 7.0
Perfluoroheptane 7.0
C15H16NO2 7.0
3,3-dimethylbutanamide 7.0
F-26 7.0
more...