Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0036572 (
seizures
)
80,221
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Heat Shock Protein BAP1 (heat shock 27-kDa-associated protein 1,
HSPBAP1
) inhibits the function of heat shock protein 27, which has a neuroprotective effect during experimentally induced epileptic neuropathology. In our study, fluorescence quantitative polymerase chain reaction, immunohistochemistry, immunofluorescence, western blot were used to test the levels of
HSPBAP1
mRNA and protein in surgical samples of the anterior temporal neocortex of patients with intractable epilepsy (IE) and normal controls samples.
HSPBAP1
mRNA was abnormally expressed in the anterior temporal neocortex of patients with IE. Moreover,
HSPBAP1
was found extensively in the cytoplasm of neurons and glial cells in all epilepsy specimens. Western blot showed a clear immunoreactive band of
HSPBAP1
in IE specimens whereas it was absent in control specimens. The expression of
HSPBAP1
mRNA and protein in the anterior temporal neocortex from patients with IE may play a role in the development of epileptic
seizures
in patients with cell loss in this brain region. Additional studies will be required to elucidate the mechanism by which
HSPBAP1
affects brain function in IE.
...
PMID:HSPBAP1 is found extensively in the anterior temporal neocortex of patients with intractable epilepsy. 1756 11
