Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0036572 (
seizures
)
80,221
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The anterior thalamus (AT) is critical for memory formation, processing navigational information, and
seizure
initiation. However, the molecular mechanisms that regulate synaptic function of AT neurons remain largely unexplored. We report that AMPA receptor auxiliary subunit
GSG1L
controls short-term plasticity in AT synapses that receive inputs from the cortex, but not in those receiving inputs from other pathways. A canonical auxiliary subunit stargazin co-exists in these neurons but is functionally absent from corticothalamic synapses. In
GSG1L
knockout mice, AT neurons exhibit hyperexcitability and the animals have increased susceptibility to
seizures
, consistent with a negative regulatory role of
GSG1L
. We hypothesize that negative regulation of synaptic function by
GSG1L
plays a critical role in maintaining optimal excitation in the AT.
...
PMID:AMPA Receptor Auxiliary Subunit GSG1L Suppresses Short-Term Facilitation in Corticothalamic Synapses and Determines Seizure Susceptibility. 3269 82
