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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of the present work was to evaluate the clinical course of epilepsy with infrequent partial attacks with complex manifestations derived from the temporal lobe. Thirty patients aged 14 to 64 years treated on an outpatient basis and discovered during epidemiological investigations were followed-up. In half the cases only attacks without generalization occurred, in the remaining cases isolated generalized seizures appeared during many years of disease duration. In both groups a decrease was observed in the frequency of seizures in patients treated systematically or irregularly, as well as in those who had never been treated. Despite a long duration of the disease (above 6 years in 24 cases) the patients had normal mental level and good social adaptation.
Neurol Neurochir Pol
PMID:[Clinical pattern of epilepsy with abortive temporal lobe attacks]. 84 Mar 59

The follow-up study reported covered two representative groups of epileptics: 289 known epileptics (group Z) and 82 cases found in a sample of general population in Warsaw (group T). During 2--3 years of follow-up the frequency of seizures has changed in 40% of cases: the percent of patients improved exceeding significantly that of patients with worsening or relapse. The remaing 60% of cases consisted of two almost equally numerous groups: patients with unchanged frequency of seizures and those free from seizures for years. Cases of milder epilepsy were underrepresented among the patients on medication but it is stressed that it was particularly difficult to obtain data on such cases (migrations, refusals). The frequency of relapses in the untreated group reached 10% in group Z and 5% in group. T. Many untreated epileptics continue to have epileptic seizures, usually rare.
Neurol Neurochir Pol
PMID:[Incidence of seizures and therapy course in the light of a follow-up study of 2 representative groups of epileptics]. 84 Mar 63

In a group of 90 children with phenylketonuria diagnosed and treated late the authors studied the problem of seizures. They occurred in over 50% of children, in most of them they had the character of salaam seizures (72%). They were statistically significantly more frequent in children with more severe mental retardation. In the discussion on these observations the authors stated that the data obtained by them concerning the frequency of seizures (twice as frequent as in materials reported in the literature) were based on long-term observation of these children and not on one examination and they conform better to the actual incidence of these seizures. It is supposed that the presence of seizures is a prognostically unfavourable element. It is suggested also that these children should be given anticonvulsant treatment besides dietary treatment of phenylketonuria.
Neurol Neurochir Pol 1977
PMID:[Seizures in phenylketonuria]. 88 2

Serial EEC investigations were carried out in 30 children with phenylketonuria aged 8 months to 4 years at the time of dietary treatment. All children had seizures. The results of EEG investigations in this group of children were compared with a preciously observed analogous of 35 children without convulsions. Comparing the results of EEG investigations in both groups it was observed that in the group of children without convulsions the initial EEG tracings were mostly normal while in both groups the abnormalities were mostly of paroxysmal type. On the ground of an analysis of the EEG results of both groups of children during the whole observation period lasting 2 to 7 years no statistically significant differences were observed in the pattern of bioelectric activity of the brain in both groups. In the light of this material homogenous from the standpoint of aetiology and pathogenesis the asuthors postulated the necessity of verification of the presently accepted principles of diagnosis and classification of infantile convulsions based on diagnostic and prognostic significance of EEG investigations.
Neurol Neurochir Pol
PMID:[Convulsions in phenylketonuria and the pattern of the bioelectric activity of the brain]. 89 76

In a group of 120 children with prenatal and postnatal trauma 31 children with epileptic seizures were found who accounted for 25.8% of neuropsychiatric complications in this group. Epilepsy was more frequent in children with a history of asphyxia than after other forms of perinatal trauma. Seizures were observed either immediately after birth or up to the age of 100 months. In children with delayed onset of seizures evidence of abnormal behaviour with excessive motor agitation, sleep and appetite disturbances was found from the very birth. Besides prophylactic measures applied to avoid complications of pregnancy and labour it is indispensable to separate the children with perinatal trauma and group them for further neuropsychiatric observation in outpatient clinics and to begin treatment which may prevent development of frank epilepsy in at least a part of these children and may contribute to better rehabilitation of brain-damaged children.
Neurol Neurochir Pol
PMID:[Prevention of epilepsy in children following birth trauma]. 94 84

On the basis of an analysis of a paediatric material the author discusses the most important elements influencing the pattern of developmental age epilepsy calling attention to the significance of early aetiological diagnosis since in this early period of life many processes can be treated causatively before epilepsy develops into a chronic disease. The dynamic course of epilepsy and classification difficulties resulting from clinical and electroencephalographic variability of childhood epilepsy are discussed explaining these facts by differences in structural maturity and functional organization at the age of development. It is indispensable to know the classification of seizure circuits for selection of possibly effective symptomatic treatment for prevention of seizures and their sequelae in the neuropsychiatric and social aspects. In the clinical course of a given case there are also individual differences between the seizure-releasing factors and their knowledge helps to avoid the critical threshold of seizure readiness releasing seizures in a given child. Acceptance of certain rules for observation in the everyday life of patients permits an individual prophylaxis of seizures. This shows that prevention of epileptic seizures includes not only causative and symptomatic treatment but also the knowledge of individual seizure-releasing factors which cannot be controlled pharmacologically.
Neurol Neurochir Pol
PMID:[Epilepsy of the developmental age and control of seizure-releasing factors]. 94 85

Epileptiform activity is inhibited by injection of dopamine, and potentiated by injections of haloperidol into the caudate nucleus. gamma-Aminobutyric acid (GABA) initially potentiates, and shortly after that inhibits the epileptoform activity in the cortex. The authors discuss a possibility of combined treatment of seizure states with dopamine-mimetic and GABA-mimetic agents.
Pol J Pharmacol Pharm 1976
PMID:The effect on cortical mirror foci produced by ouabain of gamma-aminobutyric acid, dopamine and haloperidol injected into the rabbit caudate nucleus. 95 9

A group of 50 epileptics (group C) with frequent seizures refractory to treatment was studied. The control group (R) comprised 50 cases with rare seizures. It was found that despite systematic treatment (with full therapeutic doses) and frequent changes of drugs the frequency of seizures was not reduced in group C. The analysis of clinical features of both groups showed that group C as compared with group R had more patients with temporal lobe seizures, neurological abnormalities, low intelligence quotient, changed background activity in EEG and longer duration of the disease. These data may suggest a greater number of cases with detectable organic brain lesions among patients with frequent seizures.
Neurol Neurochir Pol
PMID:[Analysis of clinical and social features in a group of epileptics with frequent seizures]. 95 80

Treatment with Rivotril in doses of 2-10 mg daily was given to 26 patients with various forms of epilepsy, mostly refractory to previous treatment. In 2 cases the drug was withdrawn on account of intolerance, in 4 cases treatment was stopped after several days in view of greatly increased frequency of seizures. In the remaining cases the drug was administered during 2 to 27 months, (mean 7 months) in 3 cases as the only medication and in 17 with other anticonvulsants. The best therapeutic results were obtained in patients with partial seizures of complex symptomatology and in generalized non-convulsive seizures, the worst results in generalized seizures. Electroencephalographic findings included particularly disappearance of seizure activity, while focal changes persisted and even grew worse in some cases. Apart from 2 cases of acute intolerance in another 4 cases side effects were observed with somnolence, dizziness, equilibrium disturbances, and in one case granulocytopenia developed. Allergic changes and liver or renal damage were never observed. The authors suggest introduction of the drug in treatment of epilepsy in view of its favourable clinical effect even in cases refractory to previous treatment, especially since the drug is relatively well tolerated.
Neurol Neurochir Pol
PMID:[Preliminary evaluation of Rivotril in epilepsy]. 95 82

The author reports an analysis of 83 cases of salaam seizures in children from the standpoint of their aetiopathogenesis. In accordance with Jeavons she separates a group with congenital nervous system damage and a group of children who developed initially normally but in whom an acquired factor, most often of allergic character, caused nervous system changes manifesting themselves with salaam seizures. The comparison of both groups demonstrated a number of significant differences. The author believes that it would be wrong to consider all children with salaam seizures as a homogenous group because the only common factor in them is the occurrence of seizures. The author regards that it is insufficient to explain the type of EEG changes and the type of seizures as determined by the degree of nervous system development. Additional factors must exist, and fetal injury is this factor in the group of congenital seizures while in the group of acquired seizures the allergic factor is probably responsible. The isolation of both groups is important mainly from the standpoint of prognosis and treatment since in the group with acquired disease an acute cerebral process is the cause, in contrast to the group congenital damage, and the process is amenable to successful treatment if this treatment is applied sufficiently early. In the congenital group the prognosis is usually unfavourable in view of the underlying cause which is congenital encephalopathy acquired in the first place in pregnancy.
Neurol Neurochir Pol
PMID:[Etiopathogenesis of salaam seizures]. 98 86


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