Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eighteen fully kindled rabbits, whose epilepsy had been produced by intrahippocampal (i.h.) injections of 2 microliters of diluted solution containing 0.32 or 0.55 micrograms of coriaria lactone (CL), were separated into three groups. One of them was used as the control group. For seizure, all animals were given CL (0.6-1 micrograms/2 microliter i.h.). Ten minutes later, the verapamil (VR) group of six rabbits was treated with VR (1.5 or 2 mg/kg i.m. 2.5 or 5 micrograms/2 microliters i.h.); the normal saline (NS) group (six rabbits) received 0.8 ml/kg (i.m., in the same volume as that of the VR 2 mg/kg injection) or 2 microliters (i.h.) of NS; the control group of six received neither VR nor NS. The experiments were made once every eight days. Hippocampal EEGs of all animals were recorded by telemetric method and their behavior after injection was observed continuously in 4-7 hours. The results of the experiment indicated that the i.h. administration of 2.5 or 5 micrograms/2 microliters of VR is effective on hippocampal kindled seizures induced by CL in rabbits, but the curative effects of the i.m. administration of 1.5 or 2 mg/kg of VR were less notable than those of the i.h. administration.
Hua Xi Yi Ke Da Xue Xue Bao 1992 Sep
PMID:[Effects of calcium channel blocker verapamil on hippocampal kindled seizures induced by coriaria lactone in rabbits]. 129 23

Fourteen male Wistar rats were divided into two groups. The experimental rats were injected with subconvulsive dosage of coriaria lactone (1 mg/kg) intramuscularly per 3.5 days. The controls were injected with normal saline. After 26 injections, the loci coeruleus of kindling rats were studied with the noradrenaline (NA) fluorescence histochemical technique at the time between seizures. The NA fluorescence could be clearly visualized under fluorescent microscope. The intensity of fluorescence was reflected by autoexposure-meter of the fluorescent microscope. The brighter the fluorescence, the shorter the autoexposure time. The intensity of NA fluorescence in the locus coeruleus of experimental animals was weaker than that of the controls. Since NA plays an inhibitory role in cerebral cortex, the decrease of NA, either induced by repeated injections of coriaria lactone or due to the time of sample taken after seizure, needs further study.
Hua Xi Yi Ke Da Xue Xue Bao 1992 Jun
PMID:[Noradrenaline fluorescence histochemical study on the locus coeruleus of kindling rat induced by coriaria lactone]. 145 43

Twenty-four adult male Wistar rats were used in this study. Status epilepticus was provoked in 10 rats by embedding coriaria lactone particle into the left cerebral motor cortex. In the controls were embedded particles without coriaria lactone. After 6 h of continuous seizure, the locus coeruleus was studied with the noradrenaline (NA) fluorescence histochemical technique and enzyme histochemical test for monoamine oxidase (MAO). The intensity of NA fluorescence was detected with fluorescent microscope autoexposuremeter and analysed with MIAS-200 Image Analyser. The study group showed a parallel increase of NA fluorescence as compared with that of the control group by both measurements. NA plays an inhibitory role in the cortex. Our data suggest that the increase of NA in locus coeruleus may be due to the reduction of NA release from axon terminal. Reduction in inhibition could be one of the mechanisms of seizure activity. The intensity of MAO was detected with MIAS-200 Image Analyser. The regulation of monoamine metabolism by MAO in the central nervous system and the increase of MAO activity in the continuous seizure group may be induced by the accumulation of NA in the locus coeruleus soma.
Hua Xi Yi Ke Da Xue Xue Bao 1992 Jun
PMID:[Histochemical and image-analytic study of the rat locus coeruleus during status epilepticus]. 145 44

Kindling model of epilepsy induced by intraperitoneal injection of Coriaria lactone (CL) was used in the experiment. The dose of CL was 1.25 mg/kg. Thirty rats in various periods of kindling were killed and the materials of cerebral cortex, hippocampus and cerebellum were drawn. The enzyme activities of AchE, NADHD, CCO, LDH, SDH, AcP, ANAE and AkP of these areas were observed with enzyme histochemical techniques. In another three kindled rats, two blank control rats and two NS control rats, the ultrastructure of neurons in hippocampus were observed. The results of experiments showed an increased activity of enzymes related to saccharometabolism and energy metabolism, indicating that the metabolism of brain in rats was increased by repeated kindling seizures. The mechanism of kindling seizure induced by CL may be related to inhibitory effect of CL on AchE activity of brain. The degeneration damage of brain neurons in kindled rats may result from using CL for a long time.
Hua Xi Yi Ke Da Xue Xue Bao 1991 Mar
PMID:[Observation of enzyme histochemistry and ultrastructure of brain in kindling rats with epilepsy induced by intraperitoneal injection of coriaria lactone]. 177 33

Healthy rabbits weighing 1.7-2.4 kg were used. According to Sawyer's atlas the stainless steel cannula and recording electrode were implanted into the left hippocampus of each animal. The kindling experiments were started one week after the surgical operation. For kindling, all animals received injection of 2 microliters of diluted solution containing 0.55 or 0.32 microgram of coriaria lactone (CL) every second day, through the single stainless steel cannula previously implanted in the hippocampus. Hippocampal EEG of all the animals was recorded by telemetric method and the behavior of them was observed at the same time. Eighteen fully kindled rabbits were separated into three groups. The SC1001 Na group of six rabbits was treated with SC1001 Na (100 mg/kg, i.m.), the PB Na group (six rabbits) received phenobarbital Na (30 mg/kg, i.m.), and the control group of six was treated with placebo (normal saline, i.m., in the same volume as that of the SC1001 Na injection); injections were administered once a day for two courses of treatment (one course of treatment was 1 week). The results of the experiment indicated that SC1001 Na (100 mg/kg) had certain effects on hippocampal kindled seizures induced by CL, but its curative effects were not more notable than those of PB Na (30 mg/kg).
Hua Xi Yi Ke Da Xue Xue Bao 1991 Mar
PMID:[Effects of SC1001-sodium on hippocampal kindled seizures by coriaria lactone in rabbits]. 177 35

Reserpine injection (1 mg/kg i.p.) could not only significantly reduce cAMP levels in both cerebral cortex and hippocampus in naive WC1 mice, but also potentiate the degree of seizures elicited by CL. Reserpine injection could significantly shorten CL-seizures latency and decrease its threshold, too. Reserpine pretreatment could also diminish CL seizure-induced accumulation of cAMP. These results indicated the cAMP level elevated by seizure activity was associated with monoamine neurotransmitter activity, and the seizure-induced accumulation of cAMP might take part in the process which eliminated the spread of seizure discharges and speeded up the termination of seizures.
Hua Xi Yi Ke Da Xue Xue Bao 1990 Sep
PMID:[Effect of reserpine on both CL seizures and cAMP levels in seizure mice brain]. 196 5

To study the relationship between cAMP and epilepsy, we investigated the effects of coriaria lactone (CL) on the levels of cAMP in cerebral cortex and hippocampus. Fifty normal WC1 mice were divided into 5 groups. All groups were injected with CL (2.5 mg/kg, i.m.), except the control group which was injected with NS. The concentrations of cAMP were measured after the animals had been immersed in liquid nitrogen to die at different phases of seizure development induced by CL (before seizures, in mild seizures, during severe seizures, and after severe seizures). The results indicated that the levels of cAMP in both cerebral cortex and hippocampus were significantly increased (1.73-fold and 1.33-fold) in severe seizure, and they continuously increased (1.85-fold and 1.45-fold) after severe seizures. On the other hand, no changes of cAMP were observed in mild seizures and before seizures. These data suggested that accumulation of cAMP is probably the result of seizure activity rather than the cause of seizure.
Hua Xi Yi Ke Da Xue Xue Bao 1990 Sep
PMID:[Variation of cAMP in cerebral cortex and hippocampus in seizure mice induced by coriaria lactone]. 196 94

In the present experiment, SC1001Na synthesized by West China University of Medical Sciences was used for studying to resist epilepsy induced by coriaria lactone. Forty-two normal male rabbits weighing 1.7-2.5 kg were randomly divided into four groups. The animals of the control group received coriaria lactone (3 mg/kg, i.m.). The animals in each of the experimental groups were injected separately with SC1001Na (100, 200 and 300 mg/kg, i.p.), but the control animals were not injected with SC1001Na. Thirty minutes later, the animals of the experimental groups were injected with the same dose of coriaria lactone as the control animals. The behavior of all animals before and after injection were observed continuously in 4-5 hours. The ECoG of eight animals of them were observed at the same time with telemetric method. The results of experiments indicated that SC1001Na is effective on epilepsy induced by coriaria lactone, in decreasing seizure rate, lengthening latent period, reducing seizure degree, as well as in decreasing mortality.
Hua Xi Yi Ke Da Xue Xue Bao 1989 Mar
PMID:[Studies on synthetic new drug SC1001-sodium against epilepsy induced by coriaria lactone in rabbits]. 250 40

In this experiment, the calmative and anti-epileptic effects of SC1001A were observed in fifty-five tupaias (Tupaia belangeri Yunalis), both male and female, were divided into four groups. The animals of the first group were perfused with SC1001A (400mg/kg) into their stomach. The animals of the second group were injected with coriaria lactone (5mg/kg, i.m.) for inducing seizures. The remaining two groups received SC1001A 100 and 400 mg/kg respectively by the same way as that of the first group, and 1 min later, they were injected immediately with coriaria lactone (5 mg/kg, i.m.). After the drug being perfused, the behaviors of all the experimental animals were observed continuously for 2-3 h. The results of the experiment indicated that SC1001A was possessed of a calmative effect which appeared shortly after drug (mean 12.88 min) and did not sustain a long time (mean 98 min). In addition, SC1001A was obviously effective on epilepsy induced by coriaria lactone in tupaias, in reducing the seizure rate, the times of petit mal and grand mal, as well as the duration of grand mal.
Hua Xi Yi Ke Da Xue Xue Bao 1989 Mar
PMID:[An experimental observation on the calmative and antiepileptic effects of a new synthetic drug SC1001-aminum intupaias]. 279 36

The immune adherence function of red blood cells in 17 rats was studied. It was found that the rosette rate of red blood cell C3b receptor (RBC-C3bRR) was 7.45 +/- 1.36% in the epilepsy group (8 rats), and 10.84 +/- 1.77% in the control group (9 rats); and that the rosette rate of red blood cell immune complex (RBC-ICR) was 7.42 +/- 2.62% in the epilepsy, and 10.80 +/- 1.72% in the control. As compared with the control group, the rosette rate of red blood cell C3b receptor was remarkably decreased in the epilepsy group (P < 0.05). There was no significant difference between the two groups in RBC-ICR. The results from this study demonstrated that the CL-induced seizures might result in decrease in red blood cell immune adherence function of the epilepsy rats.
Hua Xi Yi Ke Da Xue Xue Bao 1994 Jun
PMID:[Study on red blood cell immune adherence function in coriaria lactone-induced epileptic seizure rats]. 780 95


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