Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0036572 (
seizures
)
80,221
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We assessed the acute effects of some psychotropic drugs on amygdaloid-kindled
seizures
produced by low-frequency stimulation. We used the number of stimulating pulses required for the induction of epileptic afterdischarge (pulse-number threshold,
PNT
) as an indicator for the
seizure
-generating threshold, and the duration of the epileptic afterdischarge (AD duration, ADD) as an indicator for the duration of the induced
seizures
. Methamphetamine and atropine elevated the
PNT
and reduced the ADD. Haloperidol reduced the
PNT
at all tested doses and reduced the ADD at high dosage. Imipramine elevated the
PNT
at low doses and reduced the
PNT
at high dosage. Imipramine also reduced the ADD. Reserpine at high dose elevated the
PNT
without affecting the ADD.
...
PMID:Acute effect of some psychotropic drugs on low-frequency amygdaloid kindled seizures. 367 71
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