Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a 7-year prospective follow-up of 104 children with enuresis in 32 cases (19 boys and 13 girls) coexistence of common migraine was found. Twenty-two children had various other seizure-like disorders, particularly tics, febrile convulsions, pavor nocturnus and fainting, and three had absence attacks. In 20 cases vasomotor disturbances and in 17 abnormal Schellong's test were found. The IQ was normal or high in all cases. Emotional disorders were observed in nearly half the cases. The water-salt test of Decourt was done in 9 cases and it was abnormal in 8 cases. At least two abnormal EEG records were obtained in 26 cases, and in 24 of them seizure activity was demonstrated in the EEG. In the period of follow-up disappearance or very marked improvement of enuresis occurred in all cases and migrainous attacks became less frequent and intense in 27 cases, while in 5 the severity of migraine increased. The author discusses the pathological mechanism of these disturbances calling attention to less good efficiency of the regulatory functions of the centrencephalic activating system and hypothalamus connected with biochemical and bioelectric immaturity.
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PMID:[Coexistence of idiopathic spontaneous nocturnal enuresis and migraine in children]. 344 4

The present study was undertaken to see whether the recently reported synergism between lithium and carbamazepine (CBZ) in mania also extends against convulsions. The anti-convulsant effect of various doses of CBZ was assessed in albino rats pretreated with vehicle or lithium salt (0.54 mEg/kg/day, p.o. for 9 days). The animals were subjected to 3 tests: maximum electro shock seizures (MES); minimum electro convulsive thresholds (MET) and pentylenetetrazol (PTZ)-induced convulsions: abolition of hind limb extension after electro shock, increases in the MET for appearance of neck jerk and absence of convulsions for one hr after PTZ were taken as parameters of the anticonvulsive effect respectively. In the MES and MET tests lithum did not alter the anticonvulsive effect of CBZ. Lithium, however, potentiated the anticonvulsant effect of CBZ against PTZ-induced convulsions.
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PMID:Influence of lithium on the anticonvulsant activity of carbamazepine. 366 73

Since 1938, phenytoin has been widely used for the control of seizure disorders. Phenytoin is available from a variety of manufacturers in a variety of dosage forms. Certain physiochemical properties of phenytoin may lead to bioavailability changes. The physiochemical properties exert themselves not only in the presence of other drugs but also during the manufacturing process. Manufacturing processes that may influence phenytoin bioavailability include salt form, particle size, product excipient, and dosage form. Drug influences upon phenytoin bioavailability largely include antacid anions, which may form insoluble complexes. Anions present within the diet may also influence the rate and extent of phenytoin absorption. This article reviews the various influences on phenytoin bioavailability with regard to the manufacturing process, antacid, and food.
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PMID:Review of alterations in oral phenytoin bioavailability associated with formulation, antacids, and food. 372 29

Presented is the case of a normal two-month-old girl who developed seizures secondary to water intoxication. The infant had been fed 20 to 30 oz of water daily for three days, while her usual formula was withheld because of vomiting and diarrhea. On the day of admission, the infant exhibited signs of water intoxication in the form of lethargy, vomiting, and seizures. Hyponatremia, hypothermia, and hyperglycemia were noted on admission, and are common features of the syndrome. The patient responded well to fluid restriction and salt replacement. Previous reports have attributed water intoxication to feeding mismanagement, vigorous hydration, dilute formulas, and swimming lessons.
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PMID:Water intoxication with seizures. 396 5

This is a study of the effects of chronic hypernatremic dehydration and rehydration on carbohydrate, energy, and amino acid metabolism in the brains of weanling mice. Chronic hypernatremic dehydration induced by 4 days of water deprivation and salt loading was associated with severe weight loss (no other observed clinical effects), increased brain Na+ levels, and a decreased brain water content. Changes in the concentrations of brain glucose, glycolytic and citric acid cycle metabolic intermediates, and phosphocreatine were compatible with reduced cerebral metabolic rate. In adaptation to chronic hypernatremia, there was a significant increase in the content of the measured brain amino acids. Rapid rehydration over a 4-h period with 2.5% dextrose in water returned plasma Na+ levels and brain Na+ and water contents to normal. After rehydration, metabolites were altered in a manner consistent with increased fluxes through the glycolytic pathway and citric acid cycle; the brain glycogen content almost tripled. Brain taurine and glutamine levels were not lowered by rehydration, and the total content of the measured amino acids in brain was still significantly higher than in controls. We speculate that these metabolic perturbations may relate to the development of cerebral edema and seizures or coma following rapid rehydration of humans with chronic hypernatremic dehydration.
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PMID:Effect of chronic hypernatremic dehydration and rapid rehydration on brain carbohydrate, energy, and amino acid metabolism in weanling mice. 684 62

2'-Sulphonyl[3-(3H-2,4-dimethyl-1,5-benzodiazepino)]-2,5-dimethyl-6,7-ben zomorphan (3a), 2'-sulfonyl[3-(3H-2 methyl-4-phenyl-1,5-benzodiazepino)]-2,5-dimethyl-6,7-benzomorphan (3b) and 2'-sulfonyl [3-(3H-2-methyl-4-oxo-5H-1.5-benzodiazepino)]-2,5-dimethyl-6,7-benzomorphan (3c), synthesized from 2,5-dimethyl-6,7-benzomorphan (1) in three steps via chlorosulphonation, condensation with sodium salt of acetylacetone, benzoylacetone and ethyl acetoacetate separately and condensation with o-phenylenediamine, were studied for their pharmacological activities. It was found that 3a has mild CNS depressant, analgesic and anticonvulsant (against petit mal type of seizures) activities. 3b has significant anti-depressant and mild analgesic activities while 3c has CNS depressant, mild analgesic and anticonvulsant activities (against petitmal type seizures).
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PMID:Synthesis and pharmacological studies of 2'-sulphonyl[3-(3H-2,4-disubstituted-1,5-benzodiazepino)]-2,5-dimethyl-6,7-benzomorphans. 710 Feb 35

A 21-month-old girl presented with seizures and a serum sodium concentration of 206 meq/l. She had many of the features of psychosocial dwarfism, including short stature, bizarre eating and drinking habits, absent growth hormone response to arginine and insulin infusion and a rapid weight gain during her hospitalization. During the initial rehydration, the patient's weight gain was only 2 percent of her body weight. This finding probably indicates that her hypernatremia was chronic, did not represent acute dehydration and may well have derived from willful denial of water, although a chronic salt load could not be ruled out. This report further emphasizes that extreme hypernatremia may be the presenting feature of child abuse.
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PMID:Extreme hypernatremia as a presenting sign of child abuse and psychosocial dwarfism. 745 4

Neurologic disease associated with hypernatremia in 2 young Vietnamese potbellied pigs is discussed. Both pigs had recent dietary changes likely associated with excessive salt intake. Case 1 was changed from a commercial mini pig ration to a commercial cat food diet containing up to 1.5% salt 3-4 days before the onset of clinical signs. Case 2 was being maintained on a commercial mini pig ration, however the owner often fed the pig potato chips as treats since its purchase 3 weeks previously. There was no history of water deprivation in either pig. Clinical signs in case 1 included facial-motor seizures, sialorrhea, generalized seizures, tenesmus, disorientation, circling, head pressing, and blindness. Case 2 was disoriented, ataxic, underweight, and appeared blind. Both pigs fully recovered with medical therapy. The rationale for fluid and ancillary therapy are discussed in light of the pathophysiology of salt toxicosis in commercial swine.
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PMID:Neurologic dysfunction associated with hypernatremia and dietary indiscretion in Vietnamese pot bellied pigs. 831 11

Hyponatremia is rarely reported as a delayed complication of transsphenoidal resection of pituitary adenoma. Usually attributed to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), hyponatremia causes nonspecific symptoms, often after hospital discharge. To clarify the frequency, presentation, and outcome of this poorly understood complication, we reviewed our database of 2297 patients who underwent transsphenoidal pituitary surgery between February 1971 and June 1993. Of 53 patients (2.3%) treated for symptomatic hyponatremia, 11 were excluded (2 received arginine vasopressin within 24 hours, 1 had untreated hypothyroidism, 4 had untreated adrenal insufficiency, and 4 had incomplete records). The remaining 42 patients (1.8%), 11 men and 31 women aged 21 to 79 years, presented 4 to 13 days (mean, 8 d) postoperatively with nausea and vomiting (20 patients), headache (18 patients), malaise (12 patients), dizziness (4 patients), anorexia (2 patients), and seizures (1 patient). Hyponatremia was unrelated to sex, age, adenoma type, tumor size, or glucocorticoid tapering. Although the clinical picture in our patients is consistent with SIADH, this was not supported by the antidiuretic hormone levels, which were normal or low-normal in the two patients in whom they were measured, suggesting the possibility that low serum sodium may not reflect SIADH. In all patients, hyponatremia resolved within 6 days (mean, 2 d); treatment consisted of salt replacement and mild fluid restriction in 37 patients and fluid restriction only in 4 (treatment unknown in 1). Delayed hyponatremia after transsphenoidal resection of pituitary adenoma is not as rare as previously thought, nor is it necessarily associated with SIADH or with hypoadrenalism during glucocorticoid tapering.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Delayed onset of hyponatremia after transsphenoidal surgery for pituitary adenomas. 855 92

A large number of drugs can be given parenterally for the control of acute seizures, although many of these compounds are associated with serious adverse effects. Phenobarbital, the first antiepileptic drug (AED), has long been available in an injectable formulation. The sodium salt of phenobarbital is water soluble, and its parenteral formulation can be given for maintenance therapy or treatment of acute seizures. The introduction of phenytoin in 1938, and its subsequent parenteral formulation, represented a significant advance in AED therapy owing to its relative absence of sedation. However, the risk of adverse effects necessitates that the rate of phenytoin administration usually be limited to 50 mg/min. I.v. valproate has been used extensively but has not been approved for use in the United States, and its value for treating acute seizures is unclear. Several benzodiazepines have been used as adjunctive drugs for the treatment of epilepsy; given parenterally, they provide rapid CNS entry and prompt control of seizures, but their effect is short lived. Agents that have more hypnotic anesthetic properties are often used when the benzodiazepines or phenytoin alone or in combination fails.
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PMID:Parenteral antiepileptic/anticonvulsant drugs. 864 13


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