Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0036572 (
seizures
)
80,221
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Pimprinine
, an extracellular alkaloid has been isolated from the culture filtrate of Streptomyces CDRIL-312.
Pimprinine
was subsequently purified using silica gel column chromatography and also by preparatory thin layer chromatography. Some physicochemical properties, antimicrobial activities (in-vitro) and pharmacological activities of pimprinine were studied.
Pimprinine
showed promising anticonvulsant activity in both minimum and maximum electric
seizure
threshold test in mice. Its anticonvulsant activity is very much comparable to that of phenyl hydantion sodium.
Pimprinine
also inhibited effectively tremorine-induced tremors and analgesia in mice.
...
PMID:Pimprinine, an extracellular alkaloid produced by Streptomyces CDRIL-312: fermentation, isolation and pharmacological activity. 1137 60
