Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Epileptic activity of neurons consists of paroxysmal depolarization shifts (PDS) which can be induced presumably in any nervous system by application of an epileptogenic drug. The spontaneous appearance of epileptic activity, however, is based on a largely unknown process which increases susceptibility to epileptic activity (seizure susceptibility in man). It is presently shown that the treatment of ganglia with proteolytic enzymes (Pronase) decreases the effective concentration of epileptogenic drugs, i.e. increases seizure susceptibility. Since proteolytic enzymes are known to primarily affect glial cells a contribution of glia to seizure susceptibility is discussed.
 ...
PMID:Continuous increase of epileptogenic effects following application of proteolytic enzymes (buccal ganglia of Helix pomatia). 1527 Feb 43