Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0036572 (
seizures
)
80,221
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Kindling of the anterior neocortex (AC) was shown to produce a brief focal motor
seizure
, characterized by a clonic-tonic-clonic response of the forelimbs with the animal in a prone posture. These same brief
seizures
, as previously reported, did not produce retrograde amnesia in a
CER
paradigm. With repeated evocations, over several days, the AC convulsions exhibited a dramatic increase of the second clonic phase (generalized) and came to appear similar to amygdala kindled convulsions. These generalized AC convulsions, like briefly kindled amygdala convulsions, produced good retrograde amnesia for a
CER
. With extensive amygdala kindling prior to
CER
training, a severe
CER
acquisition deficit was observed. These latter as well as other data suggest that protracted amygdala kindling produces a subsequent reduced ability to acquire fear motivated responses.
...
PMID:Effects of focal vs generalized kindled convulsions from anterior neocortex or amygdala on CER acquisition in rats. 52 39
