Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sixty-five cases of mental depression were treated with maprotiline (Ludiomil), including 46 cases of endogenous depression, 18 cases of neurotic depression and 1 case of depression in association with hypertension and cerebral arteriosclerosis. Ludiomil of 50-200 mg/d was given for 4 weeks and clinical pictures evaluated weekly. Clinical results showed complete recovery in 33 cases (50%), improvement in 22 cases (34%), fair in 7 cases (11%) and poor in 3 cases (5%). Dry mouth, constipation and faintness were the commonest side effects. Seizure occurred in 1 case and skin rash in 3 cases. The authors suggest that Ludiomil at a maximal dosage of 150 mg/d can be considered a relatively safe and effective antidepressant.
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PMID:Maprotiline (Ludiomil) treatment of mental depression--a clinical report of 65 cases. 259 36

Antidepressant drug overdoses have been reported to induce seizures, but the etiology of this phenomenon is still unclear. Recently we treated three patients who suffered from epileptic seizures after acute overdoses of three antidepressant drugs: (a) Dibenzepin HCl (Noveril), (b) Maprotiline HCl (Ludiomil), and (c) Clorimipramine (Anafranil). After a review of the pertinent literature, the possible role of antidepressant drugs in the genesis of epileptic seizures is discussed.
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PMID:Convulsive attacks due to antidepressant drug overdoses: case reports and discussion. 613 96

In a retrospective study involving 680 EEG investigations in 593 patients the effects of various psychopharmaceutical agents were examined by visual interpretation of the EEG. The drugs were given singly in the majority of cases and were combined in others, and special attention was paid to the occurrence of paroxysmal EEG activity. The proportions of abnormal EEGs in the various groups were (in descending order): clozapine 59%, lithium salts 50%, butyrophenone 44%, maprotiline 37%, dibenzepine 32%, laevomepromazine and amitriptyline 31%, imipramine 9% and diazepam 4%. The proportions of paroxysmal discharges (13%) and generalized transient disturbances with groups of slow waves (16%) were also greatest in the clozapine group. During 3.5 years (1973-1974, May 1979-November 1980) we observed drug-induced generalized seizures in 16 inpatients = 0.28% of all inpatients (N = 5785) in that time. The psychotropic drugs given to these patients were either laevomepromazine (Neurocil 4x), perazine (Taxilan 3x), maprotiline (Ludiomil 3x), clozapine (Leponex 2x), lithium carbonate (Quilonum retard 2x) and amitriptyline (Saroten 2x) alone or partly in combination with butyrophenone (3x), fluphenazine (2x) and biperiden (3x). The appearance of paroxysmal EEG activity seems dose dependent and occurs more often during treatment with a combination of psychoactive compounds, than in patients receiving a single drug.
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PMID:Abnormal EEG activities induced by psychotropic drugs. 696 41