Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Petit mal is a condition characterized by absences accompanied on EEG by discharges of 3/sec spike and waves lasting more than 3-4 seconds. In 145 patients with pure petit mal (PPM) these were the only findings. They were associated with other types of seizures (APM) in 52 subjects and with myoclonic jerks of the upper limbs. (MPM) in 8. Clinical and EEG normalization was obtained in 93/111 patients with PPM with adequate therapy (84%), while the same outcome was observed in 7/31 (22%) of the subjects without adequate therapy. In the group with APM, clinical and EEG normalization was obtained in 26/34 (76%), while it was observed in 3/18 (16%) of the patients who received inadequate therapy. Among the patients with MPM, clinical but not EEG normalization was obtained in 4/8. The personal history showed a high percentage of febrile convulsions. IPS was also frequently positive. The prognosis of PM seems to be mainly related to adequate therapy. The presence of other types of seizures does not significantly modify the prognosis provided that the therapy is adequate. It is, however, important to note that signs or symptoms of neurologic impairment were rare in this group of patients, probably due to the criteria chosen for the selection of patients.
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PMID:Clinical experiences of petit mal. 311 Dec 87

The effects of aspartame (L-aspartyl-L-phenylalanine methyl ester; APM) on the neurological status of children with well-documented seizures were examined in a randomized, double-blind, placebo-controlled, crossover study. We report on 10 children (5 boys, 5 girls, ages 5-13 yr) who were tested for 2 weeks each on APM and placebo (single morning dose, 34 mg/kg). Seven children had generalized convulsions with 4 also having absence episodes. One child had absence seizures and 2 had complex partial seizures only. On each arm of the study, children were admitted to the hospital for a standard 21-lead electroencephalogram (EEG), continuous 24-hour cassette EEG, and determination of biochemical variables in plasma and urine. Subjects completed the Subjects Treatment Emergent Symptoms Scale (STESS) and parents the Conners Behavior Rating Scale. There were no significant differences between APM and placebo in the standard EEG or 24-hour EEG. No differences were noted for the STESS or the Conners ratings, and no differences were noted for any of the biochemical measures (except for expected increases in phenylalanine and tyrosine after APM). Our findings indicate that, in this group of vulnerable children, APM does not provoke seizures.
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PMID:Aspartame has no effect on seizures or epileptiform discharges in epileptic children. 750 78