Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Anxiety may be a hypothetical factor responsible for psychogenic pseudoepileptic seizures. The purpose of this study was to analyse anxiety indexes manifested in the Minnesota Multiphasic Personality Inventory. Patients were divided into three groups on the basis of a neurological examination and long-term video-monitoring. Group One (N=70; 58 F, 12 M) had only psychogenic pseudoepileptic seizures. Group Two (N=40; 31 F, 9 M) had both epileptic seizures and psychogenic pseudoepileptic seizures. Group Three (N=42; 30 F, 12 M) had only epileptic seizures and served as the control group. Patients with psychogenic pseudoepileptic seizures, alone or in combination with epileptic seizures scored significantly higher than the epileptic group on the following anxiety measures: Anxiety Sign (Gough) - AxS - (P<0.001), Expressive-repressive Index (Sandford, Webster and Freedman) - ERI (P<0.001), and the Neurotic score (Ruesch and Bowman) - NS (P<0.001). Difference between all three groups were found for the Triad Elevation Index (Lovell)-TI (P<0.001) and the Frustration Tolerance Index (Beall and Panton) - FT (P<0.005). These findings suggest that the existence of psychogenic pseudoepileptic seizures or the predisposition to such seizures is reflected in the anxiety dimensions of the personality profile. Psychological evaluation of anxiety may help us to gain a better understanding of, and discrimination between, patients with psychogenic pseudoepileptic seizures, mixed seizures and epileptic seizures.
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PMID:Anxiety as a differential factor in epileptic versus psychogenic pseudoepileptic seizures. 1253 55

Triad of leukoencephalopathy, cerebral calcifications and cysts (LCC) is a recently reported rare disease named 'Labrune syndrome' after the first case was reported in 1996 by Labrune et al. Herein, we report a case of a 36-year-old man with mild right-sided weakness and seizures for 5 years. CT of brain revealed extensive calcification involving bilateral basal ganglia, right thalamus and bilateral deep cerebellar nuclei. A supratentorial cystic lesion with blood fluid level was seen in left occipitotemporal region. MRI examination revealed diffuse symmetric white matter hyperintensity suggesting leukoencephalopathy. On follow-up, patient reported improvement in the weakness and no further seizure episodes. However, follow-up of MRI revealed persistence of lesions. Differential diagnosis considered were parasitic infections (hydatid, cysticercosis), Coat's plus disease and causes of diffuse cerebral calcification like Fahr's disease and post-radiotherapy/chemotherapy. Serology for parasitic infections was negative. No history of radiotherapy or chemotherapy in the past could be elicited in the history. Another close differential is Coat's plus disease which can mimic LCC pathologically.
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PMID:A case of leukoencephalopathy, cerebral calcifications and cysts. 2234 26