Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of angiotensin II (AT II) administered intracerebroventricularly (i.c.v.) on some behavioural reactions were studied. AT II increased the electroshock convulsive-seizure threshold in mice. Sulpiride antagonized this effect of AT II. AT II increased the exploratory behaviour of rats in open field. This effect was potentiated by nomifensine (a dopamine uptake blocker) and was blocked by haloperidol. AT II increased apomorphine stereotypy and the effect was antagonized by saralasin and haloperidol and partly by alpha-methyl-para-tyrosine (alpha-MpT) (an inhibitor of dopamine synthesis). AT II decreased the locomotor activity of mice. At doses of 0.5 and 1 microgram per mouse AT II did not change haloperidol (5 mg/kg)- or tetrabenazine (25 mg/kg)-induced catalepsy. It is assumed that the behavioural effects of AT II are realized through angiotensin receptors and through interactions between these receptors and dopaminergic transmission in the brain structures involved in the behavioural reactions studied.
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PMID:Some central effects of angiotensin II. Interactions with dopaminergic transmission. 301 44

Using a neuropharmacological approach we studied the dopaminergic influence on the effects of angiotensin II (ATII) in some behavioural reactions. Haloperidol reduced the exploratory behaviour-increasing effect of ATII in the open field. Haloperidol also reduced the apomorphine stereotypy-increasing effect of ATII. Sulpiride tended to overcome the locomotor activity-decreasing effect of ATII. Seven resp. 21 days after withdrawal of pimozide (applied for 14 days) the convulsive-seizure thresholdincreasing effect of ATII was enhanced. Haloperidol impaired the retention-facilitating effect of ATII in rats performing a shuttle-box active avoidance task. The results suggest close interactions between central DA-ergic transmission and ATII in the realization of the ATII effects on behaviour.
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PMID:Dopaminergic influence on the effects of angiotensin II in behavioural reactions. 301 81