Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of maturation and motor activity on recovery from hypoxic apnea by gasping (autoresuscitation) was investigated in Swiss Webster mice and a SW-related strain. Apnea was induced with 97% N2-3% CO2 and air given at its onset. In 69 Swiss Webster-related strain mice that gasped for at least 5s, the survival rates were 100% in 1- to 16-day-old mice, 19% in 17- to 23-day-old mice, and 90% in adults. The rates in 81 Swiss Webster mice were 100, 70, and 95%, respectively. The decrease in survival in 17- to 23-day-old mice was statistically significant for both strains, as was the difference in survival in 17- to 23-day-old mice between the two strains. Gasping was absent or of brief (less than 5s) duration in 15 Swiss Webster mice that failed to recover. Seizure-like activity was observed during hypoxic apnea and gasping but was not seen significantly more often in mice that died. Simultaneous recordings of limb movement (electromyogram) and breathing pattern indicated that movement did not interfere with the occurrence of gasping. We conclude that in adults and very young mice autoresuscitation is a powerful mechanism for recovery from hypoxia, but at an intermediate age, it is frequently unsuccessful.
 ...
PMID:Effect of maturation on spontaneous recovery from hypoxic apnea by gasping. 274 3

p-Synephrine is an adrenergic amine found in Citrus aurantium L. fruits and has been used for weight loss in dietary supplements. There are commercial products containing this substance associated to caffeine, salicin, and ephedrine. The aim of this study was to evaluate the acute toxicity of this mixture in mice of both sexes. The significative results observed after acute oral administration to male and female mice of 300, 350, and 400 mg/kg total of p-synephrine, ephedrine, salicin, plus caffeine in a 10:4:6:80 w/w ratio included a reduction in locomotor activity and ptosis in all treated groups for both sexes. Seizures were also observed in male (400 mg/kg) and female groups (350 and 400 mg/kg). Gasping and tearing were observed in males. Salivation (400 mg/kg), agitation (350 and 400 mg/kg), and piloerection (all treated groups) were significantly observed only in females. Deaths occurred in males at 350 and 400 mg/kg treated groups and the necropsy showed cardiopulmonary hemorrhage. A reduction in locomotor activity was confirmed through the spontaneous locomotor activity test, in which the number of crossings considerably decreased (P < .01) in all treated groups. The rotarod test showed a decrease in motor coordination at 400 mg/kg. Body temperature decreased significantly (P < .01) in all treated groups compared to controls. The results suggested clear signs of toxicity of p-synephrine, ephedrine, salicin, and caffeine association; this toxicity augments the attentiveness on commercial products containing this mixture, given the expressive number of adverse events related to its utilization.
 ...
PMID:Toxicological effects of a mixture used in weight loss products: p-synephrine associated with ephedrine, salicin, and caffeine. 2240 69