Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An 81-year-old woman had chills, fever, nausea, vomiting, and epigastric pain. On day 3 she had hematuria and was treated with trimethoprim-sulfamethoxazole. On day 5 she had a cough, hypotension, anemia, azotemia, and elevated hepatic enzyme levels. Her condition deteriorated with thrombocytopenia, anuria requiring dialysis, edema, and hypoalbuminemia. Treatment with chloramphenicol and doxycycline was started on day 10. By day 11, she was in hypotensive shock; on day 12 she had seizures and died. Murine typhus was diagnosed by demonstration of antibodies to Rickettsia typhi by indirect immunofluorescence. Necropsy revealed interstitial pneumonia, pulmonary edema, hyaline membranes, alveolar hemorrhages, petechiae and vasculitis in the central nervous system, interstitial myocarditis, multifocal interstitial nephritis and hemorrhages, splenomegaly, portal triaditis, and mucosal hemorrhages in urinary tract. Immunofluorescent R. typhi were demonstrated in the lungs, brain, kidneys, liver, and heart. This unusual death occurred in an elderly patient without rash who was treated too late with antirickettsial drugs.
 ...
PMID:Histopathology and immunohistologic demonstration of the distribution of Rickettsia typhi in fatal murine typhus. 249 81

A 36-year-old with end-stage renal disease secondary to hypertensive nephrosclerosis had a two-day history of epigastric pain and nausea. Soon after admission, multiple grand mal seizures uncontrolled by intravenous phenytoin sodium and diazepam developed. His calcium level was 14 mg/dL and his amylase level was 2,230 mg/dL; lumbar puncture was normal. Hemodialysis lowered his calcium level to 10.7 mg/dL but failed to control his seizures. Secondary hyperparathyroidism was thought to be the cause of his malignant hypercalcemia, and an emergency subtotal parathyroidectomy was performed. Postoperatively, his grand mal seizures resolved. Confusion and aphasia also developed, but they resolved over the ensuing three weeks. Microscopic examination of the parathyroid glands revealed diffuse chief cell hyperplasia. Preoperative parathormone level was 2,196 pg/dL (normal, less than 450 pg/dL). A review of the literature has failed to reveal a similar case.
 ...
PMID:Secondary hyperparathyroidism manifesting as acute pancreatitis and status epilepticus. 728 72

Of 264 patients aged 15 years or more who underwent hematopoietic stem cell transplantation between 1989 and September 1998 at the Tokyo Metropolitan Komagome Hospital, 47 were infected by the varicella-zoster virus (VZV). In 2 patients, visceral disease preceded cutaneous dissemination. One of these patients exhibited gastrointestinal symptoms followed by disseminated skin rash 6 days later. In the other patient, epigastralgia developed and was followed by seizures secondary to meningitis; the appearance of a skin rash 5 days after these initial symptoms yielded the diagnosis. Early diagnosis and treatment of VZV infection are important, especially for patients who present with visceral symptoms suspected to be due to VZV.
 ...
PMID:[Varicella-zoster virus infection after hematopoietic stem cell transplantation]. 1069 94

The genetic analysis of simple Mendelian epilepsies remains a key strategy in advancing our understanding of epilepsy. In this article, we describe a new family epilepsy syndrome, partial epilepsy with pericentral spikes, which we map to chromosome 4p15. We distinguish it clinically, electrophysiologically, and genetically from previously described Mendelian epilepsies. The family described is a large Brazilian kindred of Portuguese extraction in which affected family members manifest a variety of seizure types, including hemiclonic, hemitonic, generalized tonic-clonic, simple partial (stereotyped episodes of epigastric pain), and complex partial seizures consistent with temporal lobe epilepsy. The syndrome is benign, either requiring no treatment or responding to a single antiepileptic medication. Seizure onset is in the first or second decades of life, with seizures in individuals up to the age of 71 years and documented encephalogram changes up to the age of 30 years. A key feature of partial epilepsy with pericentral spikes is a characteristic encephalogram abnormality of spikes or sharp waves in the pericentral region (centroparietal, centrofrontal, or centrotemporal). This distinctive encephalogram abnormality of pericentral spikes unites these several seizure types into a discrete family epilepsy syndrome. As with other familial epilepsies, the inherited nature of this new syndrome may be overlooked because of the variability in penetrance and seizure types among affected family members.
 ...
PMID:Partial epilepsy with pericentral spikes: a new familial epilepsy syndrome with evidence for linkage to chromosome 4p15. 1211 80

Severe preeclampsia is a pathophysiological disorder specific to pregnancy and characterized by vasoconstriction and hypercoagulability. Eclampsia (convulsion associated with preeclampsia) and hemolysis, elevated liver enzymes, and low platelet count associated with preeclampsia (HELLP syndrome) are serious complications in patients with severe preeclampsia. They are thought to be characterized by generalized vasoconstriction and reduction in blood flow to various organs that may be explained by increased sensitivity of the vascular smooth muscles and increased vasopressors. Liver involvement in eclampsia and preeclampsia is referred to as HELLP syndrome, and epigastric and right upper quadrant pain is often a symptom of severe preeclampsia and may be indicative of imminent convulsions. In addition, marked dilatation of the stomach and the colon is often demonstrated in these patients. These phenomena result from the hyperactivity of the sympathetic nervous system but are not caused by the hyperactivity of the parasympathetic nervous system. The authors experienced two cases of eclamptic seizures after the administration of an anticholinergic (scopolamine butylbromide) in patients with severe preeclampsia complicated by HELLP syndrome. Anticholinergics, blocking agents of the parasympathetic nervous system, can enhance the hyperactivity of the sympathetic nervous system; therefore, vasospasms of the vessels may be easily aggravated, and eclamptic seizures may be induced in patients with severe preeclampsia, especially in those complicated by HELLP syndrome. The administration of anticholinergics should be avoided in patients with severe preeclampsia, especially when there is epigastralgia.
 ...
PMID:Anticholinergics induce eclamptic seizures. 1253 41

A retrospective review of 302 cases of eclampsia treated at the Specialist Hospital Gombe (SHG), between January 1st 1997 and December 31st 1999 is presented. Intrapartum eclampsia was the commonest presentation, occurring in 166 (55.0%) patients. Headache, blurred vision, and epigastric pain preceded the first episode of seizure in 272 (90.0%) of the cases. The diastolic blood pressure of 110 mmHg or more was recorded in 102 (33.8%) of the study group. Eclampsia was more common among teenage mothers 202 (66.9%), and primigravidae 222 (73.5%). Spontaneous vaginal delivery occurred in 159 (52.6%) of the patients. Caesarean section was performed in 122 (40.4%) of the cases. Pyrexia was the commonest morbidity. There were 35 maternal deaths giving a case fatality rate of 11.6%. There were 111 (36.8%) perinatal deaths during the study period. Expanded sections in mass media education of the general populace and counselling young women on care during pregnancies are suggested. The provision and use of life-saving treatment is paramount, at the same time efforts towards eliminating the conditions that created the unbooked emergencies are crucial.
 ...
PMID:The analysis of eclamptic morbidity and mortality in the Specialist Hospital Gombe, Nigeria. 1476 49

Dengue fever is an acute febrile viral disease, which frequently presents with high fever, headache, bone pain and skin rash. Acute pancreatitis and seizure are rare manifestations of dengue virus infection. A 66-year-old woman with diabetes mellitus presented with epigastralgia, nausea, vomiting, diarrhea and fever. Acute pancreatitis, abnormal liver function and thrombocytopenia were diagnosed at a local hospital. After persistent fever, thrombocytopenia and seizure developed she was transferred to our medical center. Dengue virus infection was confirmed by serology study and dengue hemorrhagic fever grade II was diagnosed. No further neurological symptoms occurred and pancreatitis improved gradually after supportive care. She recovered and had no sequelae at 1 year follow-up. Acute pancreatitis and seizure may be manifestations of dengue virus infection, especially in patients with delayed diagnosis, prolonged fever and thrombocytopenia.
 ...
PMID:Dengue hemorrhagic fever complicated with acute pancreatitis and seizure. 1554 56

A 34-year-old grand multipara (para 7, 4 alive) was managed at the National Hospital, Abuja, Nigeria for acute renal failure due to HELLP syndrome following referral from a peripheral hospital. She presented with a history of vomiting, headache, epigastric pain, loss of consciousness and tonic/clonic seizures. Though she was unsure of her exact dates, clinically the gestational age was estimated at 22 weeks. She was managed in the intensive care unit, following delivery of a macerated fetus within 15 h of hospital admission. The patient received mechanical ventilation and three sessions of haemodialysis as part of her successful management while in the intensive care unit. The uncommon presentation of eclampsia and HELLP syndrome before obvious preeclampsia is discussed, as well as the other signs and symptoms and patient management. The case also highlights the resource-poor environment of peripheral and tertiary hospitals in Nigeria.
 ...
PMID:Acute renal failure due to HELLP syndrome and acute renal failure in mid gestation. 1593 39

We report a patient presenting with severe epigastric pain and diffuse abdominal tenderness, with negative imaging and endoscopic evaluation. During hospitalization, the patient developed confusion, seizures, pneumonia, anemia and thrombocytopenia. A hemorrhagic rash appeared on day nine of admission, with serology and skin biopsy confirming a diagnosis of hemorrhagic varicella.
 ...
PMID:Disseminated varicella presenting as acute abdominal pain nine days before the appearance of the rash. 1884 77

Hypertensive pathologies during pregnancy lack definition. Meanwhile, we can offer the following definitions: - Gestational hypertension (GHT): Systolic HT >or= 140 mmHg and/or diastolic blood pressure 90 mmHg. Which occur beyond the 20th week of amenorrhea and fading before the 42nd day postpartum. - Preeclampsia: Systemic HT associated with a proteinuria (> 0,3 g/24 h) also arising beyond the 20th week of amenorrhea and resolving by the 6th week postpartum. However, in the setting of a GHT associated with a number of abnormal signs & symptoms (i.e. hyper-reflexia, epigastric pain, etc.) and/or abnormal biological values (i.e. raised transaminase levels, thrombocytopenia, hyperuricaemia, haemolysis) and/or IUGR, PE must be considered until proven otherwise. - HELLP syndrome: Association of haemolysis, elevated liver enzymes (transaminases & LDH) and thrombocytopenia. However, HELLP syndrome can exist without haemolysis. - Eclampsia is defined as the occurrence of tonic-clonic seizures in a setting of GHT. Assessing the morbidity and mortality of both the mother and the foetus, in the setting of GHT, is a challenge because of the absence of registry, and because of the high amount of bias (gestational age, birth weight, presence or absence of risk factors in the studied population, belonging to a developed or a developing nation, etc.) which all account for the large discrepancies in the results to such an extent that the relative risk to the mother can vary from simple to the double, and the foetal risks are highly variable from one study to the next.
 ...
PMID:[Gestational hypertensions: definitions and consequences in outcome of pregnancy]. 2030 96


1 2 Next >>