Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

When deployed away from base, men and women aboard seagoing vessels have restricted access to dental care. Situations may arise in which untreated disease, acute infections, failing restorations, or trauma result in pain or discomfort. Military dental health care delivery systems seek to minimize episodes of dental pain through routine screening by recall and delivery of treatment. A 12-month survey of all unscheduled attendances aboard British warships was conducted to establish the frequency and nature of cases, particularly with respect to recall status. One thousand three hundred forty-one reports were received from 66 ships and shore-based clinics, equivalent to approximately 52 occurrences per 1,000 personnel per year. The nature of the causes was widely varied. Significant relationships were apparent for recall status (treatment required) and the reported causes of dental caries (odds ratio [OR] 4.16, 95% confidence interval [CI] 1.34-13.8), periapical abscess (OR 3.19, CI 1.06-10.03), and failed restorations (OR 4.22, CI 1.31-15.01). In terms of mean time elapsed since last dental visit, those cases in the Fit/Fleet Ready group went 154 days, whereas those in the Treatment Required dental recall group went a mean of only 95 days.
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PMID:Dental recall status and unscheduled dental attendances in British warships. 885 57

The history of a patient who suffered encephalopathy and coma is presented. A 25-year-old female consumed large quantities of cold water over several weeks, to control long-term dental pain. This eventually led to dilution hyponatraemia, followed by a seizure and encephalopathy. The patient made a good recovery after spending three days in neurological intensive care. Conventional endodontic therapy immediately resolved her symptoms following recovery from this life-threatening episode. Prior to her admission the patient had experienced difficulties in gaining access to effective emergency dental care. Her problems could have been avoided if appropriate management had been provided sooner. The dental profession should be aware of the potential life-threatening risk when continued water consumption is used to control the long-term pulpitic pain. Primary care agencies should ensure that information on local emergency dental services is well disseminated to the population. Dental surgeons should be able to manage acute dental pain.
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PMID:A life threatening event from poorly managed dental pain--a case report. 1747 Nov 91

Antiepileptic Drugs (AEDs) are commonly associated with haematological disorders, including anaemia, thrombocytopenia, neutropenia and even bone marrow failure. Fatal disorders like aplastic anaemia are uncommon. On exploring through the literature, older AEDs are more associated with haematological alterations than newer AEDs, and careful monitoring is warranted especially with phenytoin, carbamazepine and valproate. The exact cause of these alterations is not established, though immune mechanisms and pharmacology of individual drugs are the proposed mechanisms, a further research along this path is underway. Of worth mentioning here, this predilection of older AEDs towards haematological disorders is pronounced in children compared to adults. We present here a case of congenital heart disease with history of brain abscess and seizures, on carbamazepine who presented to our hospital with toothache. Routine screening prior to tooth extraction revealed thrombocytopenia. Further evaluation revealed the association of carbamazepine and thrombocytopenia, which mandated discontinuation of drug and switching patient to alternative AED.
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PMID:Carbamazepine Induced Thrombocytopenia. 2920 63