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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The "grand mal" pattern of Gibbs, Gibbs and Lennox was observed in records of 14 patients during the past 3 years. It occurs most commonly in those epileptic patients who suffer from primary generalized seizures of more than one seizure type and in whom akinetic attacks are the main clinical problem. In addition, there is usually some degree of intellectual limitations. The EEG features and clinical accompaniments of the discharge were described and since the term "grand mal" discharge is not appropriate, it is suggested that it be replaced by either "generalized repetitive fast discharge", as had been suggested in the European literature, or "beta band seizure pattern".
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PMID:The grand mal pattern of Gibbs, Gibbs and Lennox. 5 66

Embolism of the right middle cerebral artery regularly failed to induce clinical or electrical seizure activity during acute ischemia in primates. This negative correlation casts some doubt on the popular interpretation of seizures at the outset of clinical stroke as evidence of cerebral embolism.
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PMID:Laboratory note. EEG changes after acute cerebral embolism. 5 70

303 patients underwent brain biopsy; 20 patients were available for a follow-up EEG examination, up to 16 years after the biopsy. 4 patients (20%) had focal fits starting within 6 months after the intervention. In the EEG of 15 patients (75%) 2 varieties of focal abnormalities appeared: "trepanation activity" which, for reasons discussed below should be regarded as an abnormality; and other focal features, including spikes, more often seen in patients with epilepsy. It is concluded that irritative brain lesions appear in a considerable number of patients after brain biopsy. The decision of performing this diagnostic procedure should be made after taking in consideration that: by enhancing the possibility of a correct diagnosis we may induce focal seizures in every fifth patient and irritative phenomena in three fourths of their EEG'S.
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PMID:Late effects of brain biopsy. 5 35

A distinct neurological syndrome in twelve chronic haemodialysis patients is described. This syndrome is currently the leading cause of death in one Denver dialysis unit. The hallmarks of this syndrome are progressive speech difficulties, mental changes, and a markedly abnormal electroencephalogram which may be present months before the clinical signs appear. Additional clinical features including seizures, myoclonus, asterixis, apraxia, focal neurological signs, and psychiatric symptoms may also be observed. Neuropathological changes are slight and non-specific. The aetiology of this syndrome is unknown but the clinical and pathological features suggest a toxic/metabolic disorder. To date, this disorder has been refractory to several therapeutic measures.
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PMID:A fatal encephalopathy in chronic haemodialysis patients. 5 86

Open- and closed-eyed EEG records were made in frontal, temporal and occipital regions, in order to examine the time relationships between various of their characteristics, in connection with the appearance of subclinical seizure patterns. 1. In the range of alpha frequency, both with open and closed eyes, the standard deviation of frequency over all brain areas decreased both before and after subclinical seizure patterns as compared to periods without pattern, and the number of temporal waves was reduced. Frontally, the mean amplitude was increased only in open-eyed records. The time relationship of the appearance of alpha maxima differed over all regions, but was closest in frontal records in both open- and closed-eyed records, and independent of the pathological pattern. In closed-eyed frontal records, a changeover in the time lead between the hemispheres could be observed, with one side leading during the period preceding the pattern, and the other after the pattern. 2. In the range of theta frequency, occipital open-eyed records showed slowing of the frequency both before and after the subclinical seizure pattern, with an increase in the standard deviation. In closed-eyed records made in the period preceding the pattern, an increase of the mean amplitude was observed frontally and occipitally, as well as an increase of the standard deviation of the amplitude in all regions. Slowing of the theta frequency was encountered in the frontal regions. Differences in the periods preceding and following subclinical seizures were to be seen only in the theta range.
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PMID:Relationship between background activity and subclinical seizure pattern. 5 33

Two children manifested EEG discharges which were triggered by blinking and/or eye closure in light and in darkness. The first case demonstrated single focal posterior discharges with eye blinks and repetitive focal posterior sharp wave discharges with eye closures. No photoparoxysmal responses were obtainable. Case 2 manifested generalized epileptic discharges triggered by eye closure which were sometimes associated with clinical seizures. In addition she showed photoconvulsive responses. Since the discharges triggered by eye blink and by eye closure occurred in both bright light and in darkness it is suggested that sensory afferents arising from contraction of the orbicularis oculi muscles may have been the epileptic trigger in Case 1 and could have contributed to the epileptic triggering mechanism in Case 2.
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PMID:Epileptic discharges triggered by blinking and eye closure. 5 37

Thirty-one, previously untreated, adult outpatients with idiopathic or focal grand-mal and/or focal minor seizures were treated initially with phenytoin. Serum-phenytoin concentrations were monitored to achieve an optimum range of 10-20 mug/ml if necessary. With a mean duration of follow-up of 14-7 months, only three (10%) patients have required the addition of a second drug, although without the guidance of serum concentrations sixteen (54%) might have been treated with a further drug. In the optimum serum-phenytoin range only 1 grand-mal attack occurred in this series, compared with a mean pre-treatment grand-mal seizure-rate of 1-1/month. Serum phenytoin declined slowly in fourteen (45%) patients. These observations suggest that many epileptic patients could be satisfactorily treated with one drug instead of the polypharmacy which they usually receive.
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PMID:One drug (phenytoin) in the treatment of epilepsy. 5 34

Over 200 children from a group of 628 were followed up after 25 years. The children were identified as having had at least one seizure. Particular attention was given to the long-term prognosis in relation to medical, social, and educational problems. Although nearly two-thirds of the sample suffered minimal ill-effects, the problems of the remainder were considerable. 10-1% had died. Of the survivors 11-2% were confined to institutions, and 6-6% were invalids at home. Just under a quarter had chronic epilepsy. While overall the educational achievement of the sample was good, there was also a considerable number of educational problems. Continuing epilepsy was associated with greatly reduced educational and occupational achievement compared with the group in remission. The study reveals the considerable cost of epilepsy to the community in both human and material terms. It also reveals why epilepsy is regarded as a frightening illness.
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PMID:Childhood seizures: a 25-year follow up. Social and medical prognosis. 5 48

Different stages of epileptogenesis of neurons in deep temporal lobe structures have been studied with fine wire microelectrodes chronically implanted in patients with drug-refractory psychomotor epilepsy. The interictal firing patterns of single neurons ipsilateral to the focus (identified by EEG seizure onset and/or neuropathology studies and seizure reduction following anterior temporal lobectomy) often exhibited burst when contralateral neurons did not. The intraburst sequence of action potentials was not organized or reliable except in one focal hippocampal neuron. Bursts of action potentials often occurred in the absence of regional sharp waves recorded with the same microelectrode; however, sharp waves with fast rise times were almost always associated with action potentials from nearby neurons. During sub-clinical EEG seizures, when EEG abnormalities did not propagate contralaterally, neurons were activated in rough proportion to the intensity of EEG activation and extent of spread of seizure activity to ipsilateral temporal lobe structures. During clinical seizures, involving both hemispheres, firing rates of neurons near the focus increased during the small amplitude high-frequency EEG phase and decreased as this high-frequency rhythmical waveform increased in amplitude. Variable firing rates followed until the clonic EEG phase, where a reliable excitation of neurons occurred during the sharp waves and strong inhibition during the following slow waves. Between these sharp--slow wave events many neurons were inhibited, but to a lesser degree and for longer than the post-excitation inhibition. These neurophysiological phenomena are discussed in relation to the literature on cellular mechanisms of epileptogenesis in experimental epilepsy.
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PMID:Epileptogenesis of human limbic neurons in psychomotor epileptics. 5 52

Serum-immunoglobulin concentrations were measured in 364 patients with epilepsy. On dividing the patients into those treated with or without hydantoins, and according to possible aetiological factors, a characteristic pattern emerged. Irrespective of the treatment given, the mean values of IgA were significantly reduced in patients in whom constitutional factors were apparent, including those with familial prevalence of seizures. While IgA was rarely found below 0-6 mg/ml, a limit chosen to define IgA deficiency in patients not treated with hydantoins, the IgA level was subnormal in 20-25% of the patients treated with such drugs. In contrast, the mean concentration of IgA was normal and no individual subnormal values were observed in epileptic patients treated with or without hydantoins whose disease was thought to be secondary to traumatic or infectious events or to metabolic disturbances. The data suggest that epilepsy with constitutional characteristics might predispose to low IgA, but that IgA deficiency only occurs when hydantoins are given. Whether this postulated predisposition is relevant to the aetiology or pathogenesis of epilepsy remained unresolved.
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PMID:IgA deficiency, epilepsy, and hydantoin medication. 5 43


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