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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifty infants and young preschool children seen in a pediatric developmental service and diagnosed as having "autism" all had evidence of organic disease of the brain and three fourths had mental deficiency of varying degrees. They did not differ in any respect from a comparison group of patients with central nervous system dysfunction unassociated with the symptom complex of autism. Both groups of patients had a high incidence of low birthweight, complications of pregnancy and the neonatal period, seizure disorders, and a variety of specific disease entities associated with developmental defects. Follow-up of 40 of the 45 survivors for a mean of five years showed that none of the patients had had treatment directed to their psychotic symptoms. However, three fourths had established social responses appropriate to their level of function; those who did not generally were over 3 years of age at the time of their first examination or had initial DQs of 35 or less. The degree of mental deficiency was as great or greater at follow-up than it was initially.
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PMID:Some etiologic and prognostic factors in early infantile autism and psychosis. 4 57

(1) Electrical stimulation therapy for patients suffering with labile signs and symptoms, and these include all varieties of acute and chronic pains, seizures and spasticity, has come into fashion and gone, and come again with each new technological advance for the past two hundred years. (2) A proportion of patients with chronic disease have their suffering made worse if they feel deprived of the latest therapy and may be relieved if they are given it in the right circumstances. In this group the relief will usually be temporary and the limited supply of such reactors will promote the cycle of fashion. In a group of 126 patients with chronic pain associated with organic disease who were offered transcutaneous stimulation, only 23 (18%) continued to use it one year after they started. (3) The cycling of therapeutic fashion is assisted not only because relief is often temporary, but also by the difficulty in establishing the normal range of variability from which significant change can be assessed and by the uncertain relationship between signs and symptoms and for the functions of daily living. For these reasons there is an inevitable tendency to temporary over-optimism and it seems impossible to counter this by the execution of a satisfactory clinical trial, since the patient cannot be "blind" and a significant variable is the enthusiasm with which a therapy is surrounded. (4) Electrical stimulation by cutaneous devices or implants can give much benefit to some patients in whom other methods have failed and there are indications, not only from anecdote and clinical impression but also now from experimental physiology, that it may benefit by mechanisms of interaction at the first sensory synapse. It is, however, an over-simplification to regard any therapy as either strictly physiological or simply fraudulent. Like other so-called placebos, physical methods of therapy can presumably act on hormonal systems associated with stress and the experience of pain.
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PMID:Therapeutic electrical stimulation. The transistorized placebo? 37 57

The relation of epilepsy with gestation was studied in 59 patients through 153 pregnancies. In patients with idiopathic epilepsy, 45 per cent had more frequent fits during pregnancy, 50 per cent were unchanged, and 5 per cent were improved. The results in patients with symptomatic epilepsy were similar. Patients with a high frequency of fits in the pregestational state are likely to have an increased number when pregnant. Two cases of status epilepticus were treated successfully without interruption of pregnancy. Fourteen patients had true gestational epilepsy, 4 of whom had underlying organic disorders. Congenital heart disease occurred in 2 per cent and cleft lip or cleft lip and palate in 1 per cent of infants, all of these mothers on antiepileptic therapy. The rate was 4 and 10 times the rate in 69,000 consecutive births in the same area. Prompt control of repeated seizures during pregnancy is imperative, folic acid should be given , accumulation of water prevented, and patients who have their first fit during pregnancy should be investigated.
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PMID:Epilepsy and pregnancy: a study of 153 pregnancies in 59 patients. 80 4

Simple febrile convulsions occur in otherwise normal children, aged six months to five years, with extracranial infection. Cerebrospinal fluid examination should be done on all children with their first febrile convulsion to rule out an underlying organic disease, especially purulent meningitis. Initial treatment includes antipyretics, tepid sponging and intramuscular phenobarbital. If a seizure recurs, the usual anticonvulsant measures should be carried out and, if prolonged, the patient should receive appropriated doses of diazepam or phenobarbital, intravenously. Patients with suspected epileptic convulsive disorders precipitated by fever, or those with seizures thought to be associated with underlying organic disease, should be hospitalized for further evaluation or treatment or both. Patients with simple febrile convulsions have a benign disorder and can be safely treated as outpatients.
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PMID:Simple febrile convulsions. 127 94

One of the most frustrating problems for veterinarians is the animal with a recurring behavioral disorder that is apparently a seizure disorder. Similar human disorders have been shown to be caused, in most cases, by organic disease in the cerebrum. There are reports in the veterinary literature that appear to support the same theory; however, there is no well-designed study with adequate animal numbers that proves the syndromes to be the same as in human medicine. It is clear that much research needs to be done. Diagnostic work up should be done meticulously, with emphasis on looking for intracranial disease. Treatment with phenobarbital is recommended to control the seizures, although the results will be variable.
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PMID:Complex partial seizures. Behavioral epilepsy. 252 Jan 38

Seven children with illnesses diagnosed as hysterical conversion reactions (HCRs) were treated at our institution over a period of nine months. They all had neurological symptoms that included one or more of the following: paralysis, headache, seizures, and episodic blindness. All patients but one were misdiagnosed as having an organic disease prior to our final diagnosis. Five children were treated with medications for presumed organic illnesses. In all of these children a diagnosis of HCR was made on the basis of their history and neurological examination findings. They all recovered or began recovery within a few days of having HCR diagnosed, and none of them had had a relapse three to 11 months after the diagnosis of HCR was made. We believe, and there is ample evidence in the literature, that a positive diagnosis of HCR in childhood can be made when neurological manifestations cannot be explained on an anatomic and physiological basis. Although absence of an obvious organic cause is a helpful clue, exhaustive exclusion of all possible organic causes is not necessary for the diagnosis of HCR.
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PMID:Hysterical conversion reactions mimicking neurological disease. 317 27

The report concerns 100 children (64 boys, 36 girls, 2-15 years old) with psychiatric disorders due to mechanical injuries of the brain. The symptoms occurred for the most part within 1-3 years after the injury. They were: encephalopathy (35 cases), characteropathy (5), neurosis (16), epilepsy (44). Epilepsy was the most important posttraumatic problem, particularly the focal form of epilepsy. There was conformity between focal changes in the EEG curves and the clinical character of seizures. The age of the child at the moment of the injury, the gravity of the injury, and previous organic disorders caused by abnormal delivery seem to be the main factors determinant of the severity of the psychiatric sequelae of a trauma. Mechanical trauma seems to activate former latent lesions of the brain due to abnormal delivery.
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PMID:Some problems concerning psychiatric sequelae in brain-injured children. 500 68

Positron emission tomography (PET) with [18F]fluoro-D-deoxyglucose (FDG) has been used to detect seizure foci and evaluate surgical resection with localization related epilepsies. However, few investigations have focused on generalized epilepsy in children. To reveal the pathophysiology of generalized epilepsy, we studied 11 patients with generalized epilepsy except West syndrome, and 11 patients with localization related epilepsy without organic disease. The FDG PET was performed by simultaneous emission and transmission scanning. We placed regions of interest (ROI) on bilateral frontal lobe, parietal lobe, occipital lobe, temporal lobe, basal ganglia, thalamus and cerebellum. Standardized uptake value (SUV) was measured and normalized to SUV of ipsilateral cerebellum. Then, we compared the data of generalized epilepsy to those of localization related epilepsy. FDG PET revealed significant interictal glucose hypometabolism in bilateral basal ganglia in generalized epilepsy compared to that in localization related epilepsy (right side: p = 0.0095, left side: p = 0.0256, Mann-Whitney test). No other region showed any significant difference (p > 0.05) between the two groups. These findings indicate that the basal ganglia is involved in the outbreak of generalized seizures or is affected secondarily by the epileptogenicity itself.
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PMID:Semiquantitative analysis of interictal glucose metabolism between generalized epilepsy and localization related epilepsy. 1558 31

The aim of this study is to present epilepsy according to the most famous and representative Byzantine physicians throughout the whole period of the Byzantine empire. Mainly Byzantine medical texts were used as sources. The Byzantine physicians considered epilepsy to be a serious medical problem and followed the Hippocratic tradition as far as the etiology of this disease is concerned. Their pathophysiological theories of epilepsy identified the brain as the site of the problem, but, based on the Hippocratic humoral theory, emphasized causes such as an excess of humors or insufficient circulation of phlegm in the brain. It is surprising to note the accuracy of the details they provide regarding the clinical description of the disease, especially the seizures; many of these are still accepted today. It is also surprising that there was a concurrent opinion during all this medieval period that epilepsy was strictly an organic disease of the brain and the demonic origin of it a prejudice of uneducated people.
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PMID:The Byzantine physicians on epilepsy. 1633 92

Patients at times present with neurological symptoms and signs for which at times extensive investigation fails to identify any structural or organic pathology within the nervous system. These pseudo neurological syndromes can mimic almost any organic disease of the central and peripheral nervous system. Some such as pseudo seizures also referred to as psychogenic non-epileptic seizures (PNES) are more commonly encountered than others. Pseudo neurological syndromes presenting as mononeuropathies have been documented in the neurological literature. We document here a patient presenting with wrist drop suggestive of radial nerve palsy and illustrate a simple clinical test which can help differentiate between true and false (pseudo) radial nerve palsy.
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PMID:Supine catch sign--a simple clinical test to differentiate between true and false (pseudo) radial nerve palsy. 2012 90


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