Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

160 women who had died during pregnancy or after delivery were studied. Intracranial venous thrombosis (ICVT) was found in 10 (6.25%) cases. Most often extensive dural sinus phlebothrombosis and rarely isolated meningeal or cerebral phlebothrombosis were observed. Multiple thrombi in cerebral microcirculation presented the most characteristic morphological feature in all cases. Disseminated intravascular coagulation (DIC) with microthrombi in two or more parenchymal organs was found in 8 cases. Delayed clinical onset and prolonged progressive course was most frequently observed. Persistent headache, haemiparesis or haemiplegia, convulsions, epileptic seizures, disturbances in consciousness and coma occurred most often. These clinical manifestations were due to multiple haemorrhagic or ischaemic cerebral infarctions and in a single case to haemorrhage. The discussion was centered on the assumption that ICVT in pregnant and parturient women might be a distinct clinicoanatomical form of DIC.
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PMID:Intracranial venous thrombosis in relation to pregnancy and delivery. 261 68

Intracranial venous thrombosis has been described in newborns, but there have been no reports of intractable neonatal seizures due to this condition. We report cortical venous sinus thrombosis in two term neonates who presented with seizures in the first 24 hours of life. The diagnosis was made by cranial computed tomography and was confirmed by cerebral angiography. Both patients improved clinically after the intracranial venous thrombosis resolved. These patients demonstrate that intracranial venous thrombosis should be considered in the differential diagnosis of neonatal seizures.
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PMID:Cerebral venous thrombosis as a cause of neonatal seizures. 350 71

Intracranial venous thrombosis may occur at any time from infancy to old age and its clinical expression varies widely and sometimes it may present without focal signs. The most common symptoms are: headache, vomiting, transient or persistent visual obscuration, focal or generalized seizures, lethargy and coma, while papilledema is a common sign. There may also be alternating focal deficits, hemiparesis or paraparesis, or other focal neurological deficits depending on the location of the venous structures involved. Symptom onset is either acute, subacute or chronic. Even with a severe initial presentation, partial or complete recovery is possible, underlying the importance of early recognition. Antithrombotic treatment must be administered at diagnosis as soon as possible.
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PMID:Clinical presentations of cerebral vein and sinus thrombosis. 1800 54