Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We retrospectively studied 18 pregnant women from 600 cases of meningioma treated at this Institution between 1986 and 2001. The variables evaluated included clinical presentation; radiological findings; timing and extent of surgical resection; and an overview of gestational, clinical, and surgical outcomes. Visual impairment was the chief complaint followed by headache and seizures. The tumors involved the tuberculum sella (8), sphenoid wing (4), convexity (2), parasellar (2), cerebellopontine angle (CPA) (1), and anterior falx (1). Gross total resection was achieved in 14, and subtotal resection was achieved in two patients. There were no related fetal or maternal deaths. Of seven patients with advanced or progressive visual impairment who underwent resection during pregnancy, three improved noticeably, two worsened, and two were unchanged. Five other patients with visual disturbance achieved full-term spontaneous delivery with improved vision in two and improved vision after post-confinement surgery in one. Vision remained unchanged in two. Intracranial meningioma during pregnancy challenges the skill of obstetricians and neurosurgeons to secure delivery of the baby and resection of the tumor. Advances in fetal and maternal monitoring, neuroanesthesia, and microsurgical techniques allow safe neurosurgical management of these patients, and pregnancy usually continues successfully to term. Surgical intervention has no major effect on minimal residual vision or advanced optic nerve atrophy.
 ...
PMID:Management Strategy for Meningioma in Pregnancy: A Clinical Study. 1591 78

Meningioma accounts for 15% to 20% of all intracranial neoplasms. Intracranial meningioma is a common brain tumor but huge meningiomas with extracranial extensions are extremely rare. Various symptoms, including neurological deficits and epileptic seizures are very frequent in these cases. Surgery still remains the principal form of the treatment and must be preceded by appropriate preoperative diagnostics. We report an unusual case of a huge meningioma of the brain (intracranial-extracranial extension) invading and destroying the skull bone and subcutaneous and cutaneous tissue. A 44-year old man in otherwise good general health was admitted to our University Neurosurgical Clinic. The MRI revealed an intracranial-extracranial lesion invading the skull bone, subcutaneous and cutaneous tissue. The tumour was removed by microsurgery. The bone was found to be predominantly lytic, and dura was infiltrated by the tumor. The bone and the dura were completely removed together with the entire tumor. Such cases are very rarely seen these days because of modern radiology techniques A giant intracranial-extracranial meningioma is therefore very unusual. Radiotherapy is generally recommended for incompletely resected meningioma and malignant meningioma.
...
PMID:Intracranial Extracranial Huge Meningioma: Report of a Case. 2644 46