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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Benign focal epilepsy of childhood is an entity that includes characteristic clinical and electroencephalographic manifestations. Clinically, it consists of typical brief, hemifacial seizures that tend to become generalized when they occur nocturnally. The EEG findings include slow, diphasic, high-voltage, centro-temporal spikes, often followed by slow waves. Retrospective and prospective studies were carried out on 100 such patients, all of whom recovered before reaching adulthood, with the disappearance of both the clinical manifestations and the EEG findings.
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PMID:Benign focal epilepsy of childhood. A follow-up study of 100 recovered patients. 80 95

Benign focal epilepsy of childhood (BFEC) is a familial, age specific, primary seizure disorder with both clinical and electroencephalographic focal characteristic features. The mental capacity remains intact, and no related neurological deficit is known. The seizures are easily amenable to treatment. BFEC is most commonly associated with central-midtemporal spikes. In some patients occipital spikes may be found. We report three patients with BFEC and present their corresponding EEG recordings. The first, a female age 10, had a history of a single grand mal seizure. Her EEG showed simultaneous firing of two independent foci, occipital and central-midtemporal. The second, a 10-year-old boy who was evaluated for headache, had typical central-midtemporal spikes. His 8-year-old asymptomatic sister's EEG showed benign occipital-temporal spikes.
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PMID:Benign focal epilepsy of childhood: individual and intrafamilial multifocality of spikes. 311 40

Benign focal epilepsy of childhood (BFEC) is the most common form of epilepsy, in children from 3 to 12 years. Its prognosis is always favourable as far as the epilepsy is concerned. Nevertheless, recent clinical data suggest that children affected by BFEC are more likely to show learning difficulties and behavioural disturbances than their peers. We report here the preliminary findings of a prospective study of 22 children affected with BFEC. Electroclinical and neuropsychological changes observed during the first 18 months of the follow-up strengthen the conclusion of recent neuropsychological studies stressing the correlation between epilepsy and cognitive performances. The cognitive deficits affecting mainly non-verbal functions were significantly correlated with the frequency of seizures and spike-wave discharges and to the lateralization of the epileptic focus in the right hemisphere, whereas frontal functions like attention control, response organization and fine motor speed, were impaired in the presence of active BFEC independently of the lateralization of the epileptic focus. Our results indicate that maturing cognitive functions subserved by a cortical area distant from the epileptic focus are susceptible to interference with epilepsy.
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PMID:Cognitive development in benign focal epilepsies of childhood. 1057 41

Seizures and antiepileptic drugs (AEDs) affect sleep macroarchitecture and may produce excessive daytime sleepiness (EDS) in patients with epilepsy. Sleep is a potent activator of seizures and epileptiform discharges. In some patients, seizures occur exclusively or predominately in sleep. Benign focal epilepsy of childhood with centrotemporal spikes (BECTS), supplementary sensorimotor area epilepsy (SSMA) and Lennox Gastaut syndrome are a few of the more common epilepsy syndromes characterized by nocturnal seizures. Excessive daytime sleepiness is a common complaint of patients with epilepsy. Causes of EDS include seizures, AEDs, poor sleep hygiene, and coexisting sleep disorders. Pharmacologic therapy is aimed at identifying the single most effective drug for a given seizure type or epilepsy syndrome. Polytherapy is associated with a higher likelihood of adverse effects--most notably, EDS. Poor sleep hygiene leads to sleep fragmentation that can exacerbate seizures and EDS. Primary sleep disorders should be suspected in patients with EDS, particularly those treated with monotherapy at low serum drug concentrations and well controlled seizures. Treatment of sleep disorders may lead to better seizure control.
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PMID:Sleep and Epilepsy. 1182 45