Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We describe the unusual clinical course in a case of exanthema subitum with affection of the liver and central nervous system in a 10-months-old girl. HHV-6 infection was confirmed serologically (positive HHV-6 IgM from 10th to 29th day, increasing IgG-titres). At the beginning of the illness convulsions with preference to the right side were noticed, which were consistent with an encephalitis (on top to a suspected pre/perinatal lesion) and resulting in spastic triplegia. Nuclear magnetic resonance imaging and cranial computertomographic results showed severe, predominantly left-sided cerebral lesions. In addition there was clinical and biochemical evidence of an associated hepatitis. Human herpesvirus-6 has been identified as the cause of exanthema subitum. In addition, the virus is known to cause other clinical entities (lymphadenopathy, febril seizures, hepatitis, postinfectious chronic fatigue a.o.) and has been identified in brain tissues. Our observations show that the course of exanthema subitum can be complicated by affection of the liver and central nervous system. At present it is impossible to estimate the clinical outcome in our patient.
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PMID:[Exanthema subitum, encephalopathy and hepatitis caused by human herpesvirus type 6 (HHV-6) in a 10-month-old infant]. 165 45

The present article summarizes 10 years of experience in head injury rehabilitation at Loewenstein Rehabilitation Center. The goal of rehabilitation in head injured patients consists of returning to work and adaptation to: interpersonal consequences of disability; new affective needs; and capacity to attend to financial, legal and bureaucratic matters. The achievement of these goals goes far beyond neurological boundaries in the ordinary narrow sense and needs a neuropsycho-social approach. Neuropsycho-social rehabilitation in head injury has multidimensional clinical aspects. Two problems should be emphasised: a) gross neurological disability (mono, hemi, para and triplegia) found in the presence of good cognitive function (patients easy to rehabilitate) and b) minor neurological disability found in the presence of gross cognitive impairment (patients not easy to rehabilitate). Posttraumatic epilepsy needs general criteria for its management. It is preferable to wait for the first seizure in order to start anticonvulsant treatment, except for 3 at risk conditions: 1) diffuse bilateral injury 2) prolonged coma, and 3) intracerebral hematoma. The first 3 years is the maximum at risk period. The traumatic syndrome consisting of impaired insight and behaviour disturbances is underdiagnosed owing to the absence of neurological signs. The sleep disturbances accompanying head injury are usually underestimated.
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PMID:Neuropsycho-social rehabilitation of head injury. 312 29