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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nervous system involvement in systemic lupus erythematosus is frequent. Psychiatric manifestations, seizures, headaches are most often observed. Movement disorders, hemiparesis, aseptic meningitis occur more rarely. Myelitis is exceptional as is peripheral nerve involvement. CT Scan shows cerebral atrophy and sometimes hemorrhages or ischemic lesions. Pathological examination usually demonstrates cortical microinfarcts, hemorrhage and meningitis, but lesions are not always found. In these case the cause of the neuropsychiatric disorder is unknown: a transitory vascular or immune mechanism has been proposed. Corticotherapy is effective in the majority of cases, but can be occasionally responsible for an exacerbation of neuropsychiatric symptoms.
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PMID:[Neuropsychiatric disorders in systemic lupus erythematosus: a general review (author's transl)]. 702 67

253 cases of late onset epilepsy were studied prospectively. 27 cases (10.7%) had space-occupying lesion, 19 cases (7.5%) had cerebrovascular disease, 13 cases (5.1%) cerebral cysticercosis and 4 cases (1.6%) had diffuse cerebral atrophy. No cause could be detected in 190 cases (75.1%). Analysis of clinical data and radiological studies showed that a majority (85%) of patients with 'tumour' who presented with epilepsy had focal neurological deficit and/or papilloedema. Focal slow-wave abnormality in EEG also gave an indication of an organic lesion. Patients who had epilepsy for more than 1 year, infrequent attacks and partial complex seizures, were less likely to have a tumour. The role of careful clinical examination is stressed.
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PMID:Late onset epilepsy. A prospective study. 713 86

We evaluated the usefulness of computed tomography (CT) brain scanning in alcoholic patients with withdrawal seizures (n = 151) and other neurologic problems (n = 87) and compared the findings of a detailed neurologic examination to the results of CT scanning. In patients with seizures, nearly 50% of CT scans were normal, 34% showed generalized cerebral atrophy, and only 15% showed focal structural lesions. When focal neurologic deficits were present, 30% of CT scans showed focal structural lesions compared to 6% when such deficits were absent (p less than 0.0002). The frequency of potentially reversible lesions was 18% in patients with and 1% in patients without focal neurologic deficits (p less than 0.0002). Of patients treated surgically, 9% had focal neurologic deficits and 1% did not (p less than 0.03). Results were similar in alcoholic patients with other neurologic problems. Careful use of the neurologic examination adequately determines which patients need prompt CT scanning. In the absence of either focal deficits on neurologic examination or signs of acute head trauma, CT brain scanning does not improve the evaluation of patients with alcohol withdrawal seizures.
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PMID:Computed tomography brain scanning in alcohol withdrawal seizures. Value of the neurologic examination. 721 10

A previously healthy 10-year-old girl suffered sudden, binocular visual deterioration. During the next few years her neurologic and visual condition progressively worsened and she developed hypertension, seizures, ataxia, and lactic acidemia, leading to death at the age of 16 years. Bilateral optic disk pallor was followed by the loss of the foveal reflex and pigmentary maculopathy, manifested as disorganization of the retinal layers, loss of ganglion cells, degeneration of the photoreceptors and nuclei, and irregular infiltration of the retina by pigment epithelial cells. The optic nerves and tracts showed central axonal loss. Bilateral, multifocal symmetric areas of cerebral atrophy and necrosis of the neuropil and neurons in the cerebral cortex, basal ganglia, and thalamus were observed; neurons persisted in the dorsal medulla, despite neuropil degeneration.
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PMID:Pigmentary macular degeneration with multifocal necrotizing encephalopathy. 729 3

Cranial computed tomography (CCT) was used to evaluate neurologic disorders in 2 primates. In the 1st case, acute left hemiparesis developed in an adult female proboscis monkey (Nasalis larvatus). A CCT scan revealed a right frontal lobe abscess that was subsequently surgically drained. In the 2nd case, a juvenile black spider monkey (Ateles fusciceps) experienced recurrent seizures following an episode of trauma and anoxia. A CCT scan demonstrated enlarged lateral ventricles and cerebral atrophy. Computed tomography proved to be a valuable technique for localizing and characterizing brain lesions in these 2 primates, after more conventional methods of investigation had failed to establish diagnoses.
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PMID:Cranial computed tomography in the evaluation of neurologic disorders in two nonhuman primates. 732 9

Three percent of epileptic patients have their first seizure after the age of 60. More than at other ages, the real nature of such fits is very difficult to assert. Most of the reversible attacks occurring at this age are not of grave nature, syncopes are much more frequent. Some semeiological aspects are discussed. Focal seizures are more frequent after the age of 60. Absence status may be the first epileptic symptom in some rare cases (almost all of them being women). 100 patients whose ages ranged from 60 to 83 years, were examined after their first seizure and aetiological problems were examined. The following topics are discussed:--The possible onset of a primary epilepsy, extremely rare at that age;--The incidence of neoplasms, not exceeding 10% for patients whose late onset epilepsy is still an isolated symptom, and who have not been selected from specialized neurological or neurosurgical hospital departments;--The role of vascular epilepsy; in a very few cases, but of great practical interest, the epilepsy may announce a cerebrovascular accident which will occur later. It is, however, difficult to specify the vascular origin of a certain number of temporary unexplained late onset epilepsies. Some other aetiological factors are taken into account: antecedents of trauma, alcoholism, and dementia. The authors agree that in 50% of the cases the aetiology is not obvious. In this group of unknown aetiology it seemed interesting to isolate the following electroclinical form;--Epilepsy grand mal, with apparently generalized seizures; no special pathological antecedents; the neuropsychological and neurological examinations are normal, showing no intellectual disorders; the EEG generally shows slight modifications: quick rhythms, some sharp waves; a global cerebral atrophy is seen by the scanner. Such patients have been called victims of 'secondary late-onset generalized epilepsy'. They form 16% of a series of 156 epileptic patients who were over 65 years old, and 21% of our own 100 patients.
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PMID:[Seizures after the age of sixty (author's transl)]. 734 7

Computerized transaxial tomography was carried out on 112 patients with partial seizures with complex symptomatology. Structural abnormalities were defined in 33% of their studies: tumors in 8 patients, diffuse cerebral atrophy in 2, focal cortical atrophy in 27 and vascular abnormality in 1 case.
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PMID:Electroencephalography and computerized transaxial tomography in patients with temporal lobe epilepsy. 737 51

Circulating immune complexes were investigated by polyethilene-glycol precipitation in the serum of 101 neurological patients from four months to 15 years old. The test was positive in 21 cases (20.7%) and 24 normal controls were negative. The polyethilene-glycol positive group had a lower seric C'3 than negative group [p < 0.02]. The highest positivity was found in meningoencephalitic infections with sequelae [6/6: 100%] and in cerebral atrophy or very important mental deficiency [11/30: 37%]. The polyethilene-glycol test was not correlated with seric IgG levels, neither in positive nor in negative groups. All patients were receiving anticonvulsivant treatment. The detection of circulating immune complexes may be the result of either brain tissue injury or of another immunological disturb found in epilepsy. There was no relationship between seric immunocomplexes and severity of epileptic disorders and it is not likely that they have any influence over seizures. The role played by anticonvulsivant drugs remains uncleared and further studies are needed.
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PMID:[Immunocomplexes in pediatrics. II: Investigation in neurological patients (author's transl)]. 741 46

Congenital and acquired cerebrovascular diseases in the very young age group are reviewed and discussed. Whilst saccular aneurysms are rare arteriovenous malformations and cavernous hemangiomas represent the most frequent types of all congenital anomalies. The aneurysm of the great vein of Galen manifests in the newborn period and mostly is mistaken for congenital heart disease. If the infant survives this angioma causes hydrocephalus. A particular type of phakomatosis combines intracerebral pure venous malformation with homolateral port-wine nevus on the front, often causing epileptic seizures. Spontaneous intracerebral hemorrhage occurs in children with small cavernous hemangiomas. Acquired arterial lesions may develop during fetal life by embolism, causing porencephaly or unilateral brain atrophy. The "Moyamoya" syndrome represents a frequent multi-arterial lesion causing characteristic ischemic episodes. Etiology is still obscure. We do not even know if the disease is acquired or congenital.
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PMID:Cerebrovascular diseases in the first three years of life. 743 79

The cranial computerized axial tomography (CAT) findings in groups of patients with epilepsy, migraine, hypertension, and other general medical disorders have been reviewed to assess the frequency and patterns of focal and diffuse brain damage. In addition to demonstrating focal lesions in a proportion of patients with seizures and in patients presenting with a stroke, the CAT scan showed a premature degree of cerebral atrophy in an appreciable proportion of patients with long-standing epilepsy, hypertension and diabetes, and in some patients with migraine, valvular and ischaemic, heart disease, chronic obstructive airways disease, and chronic renal failure. The value of CAT as a means of screening for brain damage in groups of individuals at risk is discussed.
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PMID:Computerized axial tomography in the detection of brain damage. 2. Epilepsy, migraine, and general medical disorders. 746 20


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