Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 45-year-old man presented with headaches of 6 months' duration and generalized seizures in a cluster 2 days prior to admission. Examination revealed bilateral papilloedema and no focal deficits. CT scan showed an isodense enhancing mass lesion in the right frontobasal region with perilesional edema. Bifrontal craniotomy (with total excision of the tumor) revealed a tumor in the region of the right olfactory groove attached to the cribriform plate. Histopathological examination disclosed it to be a hyalinised schwannoma. Solitary schwannomas arising from the olfactory groove are extremely rare. Only six other cases have been reported so far. The presentation. CT scan findings and histogenesis of the tumor are discussed along with a review of the literature.
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PMID:Solitary olfactory groove schwannoma: case report with review of the literature. 1035 Feb

Solitary schwannomas arising from the olfatory groove are extremely rare. Only 15 other cases have been reported so far. A case of olfatory groove schwannoma in a 19-year-old man with seizures and without neurological deficits is described. CT scan and MRI showed a tumour in the left frontobasal region. Left frontal craniotomy and excision of the tumour revealed a tumour in the region of the olfatory groove attached to the cribiform plate. The pathology, origin, and clinical characteristics of olfatory groove schwannomas are reviewed.
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PMID:[Schwannoma of the olfactory groove]. 1119 49

Intracranial schwannomas not associated with cranial nerves are rare and seldom encountered in the subfrontal region. We report a case of subfrontal schwannoma in a 21-year-old man who presented with seizures. Radiological features resembled an olfactory groove meningioma. The histological diagnosis of schwannoma was confirmed by immunohistochemical staining with S-100 and electron microscopy. We advocate the use of immunohistochemistry and electron microscopy as adjuncts to conventional light microscopy in differentiating schwannomas from meningiomas. Surgery remains the main therapeutic modality and complete excision is associated with cure.
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PMID:Subfrontal schwannoma masquerading as meningioma. 1154 67

The August 2002 COM. A 21-year-old male presented with a single episode of generalized tonic clonic seizures. Radiology revealed a cystic tumor with mural nodule suggestive of a pilocytic astrocytoma. However, histopathological examination and electron microscopy revealed features of an intracerebral schwannoma. Therefore, although rare, in an intracerebral cystic lesion with mural nodule, the possibility of an intracerebral schwannoma should be entertained. This is important because this is a benign tumor with favourable response to resection.
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PMID:August 2002: 21-year-old male with cystic intracerebral tumor. 1258 May 52

Intracranial schwannoma not related to cranial nerves are unusual and rarely found in the subfrontal region. We report a case of cystic olfactory groove schwannoma in a 55-year- old male, who presented with late onset seizure without raised intracranial pressure. The tumor was excised completely.
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PMID:Cystic olfactory groove schwannoma. 1526 89

Schwannoma are benign, slowly growing nerve sheath tumors. They can arise from any peripheral nerve containing Schwann cells including distal portions of cranial nerves. Intracranial schwannomas arising from a subfrontal lesion are very rare. We report a case of subfrontal schwannoma in a 38-year-old woman who presented with seizures in February 2003. MRI features resembled an olfactory groove meningioma. The left carotid angiography revealed that the tumor was supplied from the anterior ethomoidal artery, but no remarkable tumor stain was detected. Bifrontal craniotomy with total excision of the tumor revealed a tumor in the left subfrontal lesion. The tumor was attached to the falx, the left frontal lobe, and the skull base, but those structures were not invaded. Unfortunately, we could not detect the left olfactory nerve. Subsequent histological examination proved that this tumor was schwannoma. A review of the literature found 27 cases including this case previously described. Arguments are raised that schwannomas in a subfrontal lesion are comparable to or even occur as intracranial schwannomas with frontal localization. Subfrontal schwannomas are very rare. For this reason they have not been diagnosed preoperatively. Further cases of subfrontal schwannoma are necessary to solve the enigma of the origin of this tumor.
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PMID:[Subfrontal schwannoma: case report]. 1595 9

Intracranial parenchymal schwannomas unrelated to a major cranial nerve are uncommon and dural schwannomas are rare. We report a 23-year-old woman without neurofibromatosis admitted with a 3-month history of seizures and left hemiparesis. Radiological investigation revealed a huge cystic tumour in the right cerebral hemisphere, attached to the falx cerebri. The solid part of the tumour showed contrast enhancement. The patient underwent excision of the tumour via a right-sided parietal craniotomy. The histological diagnosis was schwannoma. Recognition of these potentially curable tumours is important and they should be excised if possible.
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PMID:Cystic schwannoma of the falx cerebri. 1738 48

Although vestibular schwannoma is a common tumor in the cerebellopontine angle, calcified vestibular schwannoma is rare. A 59-year-old woman with sudden onset epileptic seizures, was referred to Hokkaido Neurosurgical Memorial Hospital. Neurological examination revealed left Bruns nystagmus, left deafness and left cerebellar ataxia. Brain MRI revealed a mass, about 3cm in diameter, in the left cerebellopontine angle. The mass showed heterogeneous intensity on T1- and T2-weighted and fluid-attenuated inversion recovery (FLAIR) images. Hydrocephalus was seen. On CT scan, the tumor was calcified. Preoperatively, vestibular schwannoma, meningioma, cavernous hemangioma, or thrombosed giant aneurysm were considered as differential diagnoses. The pathological diagnosis was schwannoma. For a calcified mass in the cerebellopontine angle, vestibular schwannoma should be considered in the differential diagnosis to plan appropriate treatment strategies.
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PMID:Calcified vestibular schwannoma in the cerebellopontine angle. 1788 7

A 38-year-old intact female Grizzly bear (Ursus arctos horribilis) was evaluated for progressive seizure activity, pale mucous membranes, deficient pupillary light and menace responses, and irregular shallow respiration. Because of poor response to treatment, the animal was euthanized. Gross examination revealed abundant hemorrhage in both lateral ventricles; a large, encapsulated mass within the rostral interthalamic region; and a well-demarcated, round white mass in the apex of the right ventricle. Histologic examination of the interthalamic mass revealed a resolving hematoma composed of stratified layers of fibrin and white blood cells that was surrounded by a thick fibrous capsule. Most meningeal and intraparenchymal blood vessels had multifocal degeneration, fragmentation, and fraying of the internal elastic lamina with prominent intimal proliferations and plaques. The plaques were formed by small numbers of lipid-laden macrophages (foam cells) that were intermixed with occasional lymphocytes and plasma cells. The cardiac mass was composed of pallisading and interlacing spindle cells with parallel nuclei and abundant, pale eosinophilic cytoplasm consistent with a schwannoma.
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PMID:Interthalamic hematoma secondary to cerebrovascular atherosclerosis in an aged grizzly bear (Ursus arctos horribilis) with primary cardiac schwannoma. 1911 Jul 14

Intracranial intraparenchymal Schwannomas are very rare. Twenty-eight cases of frontal intraparenchymal Schwannomas have been reported so far. These generally present with seizures, raised intracranial pressure, nasal stuffiness and epistaxis. We present a patient with frontal intraparenchymal Schwannoma who underwent frontal craniotomy and excision. At follow-up the patient is seizure free and is relieved of his symptoms.
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PMID:Frontal intraparenchymal Schwannoma--case report and review of literature. 1923 16


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