Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifteen dogs with primary hypoparathyroidism diagnosed at the University of California Veterinary Medical Teaching Hospital were compared with 13 previously reported cases. Age, sex, breed, and historical and physical findings were similar in both groups of dogs. Middle-aged females were affected primarily. A history of neurologic or neuromuscular disease was present in all 28 dogs, with 18 dogs having seizures. Posterior lenticular cataract formation secondary to hypocalcemia was suspected in six dogs. The most characteristic biochemical finding in all dogs was profound hypocalcemia (less than 6.5 mg/dl) and mild hyperphosphatemia. Serum magnesium concentrations were decreased in two dogs. Serum parathyroid hormone concentrations were consistent with the diagnosis of primary hypoparathyroidism in eight of nine dogs. Lymphocytic parathyroiditis was diagnosed in the 12 dogs from which tissue was submitted for histopathology. Successful management of the patient depended on frequent monitoring of the serum calcium concentration during initial and maintenance therapy.
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PMID:Primary hypoparathyroidism in the dog. Report of 15 cases and review of 13 previously reported cases. 306 94

A patient with post-thyroidectomy hypoparathyroidism, basal ganglia calcification, parkinsonism and seizures is reported. The parkinsonism was resistant to levodopa therapy but was not significantly improved by the correction of hypoparathyroidism. Previously reported cases are discussed, as well as the relationship between hypoparathyroidism, calcification of basal ganglia, parkinsonism and epilepsy.
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PMID:Parkinsonism, basal ganglia calcification and epilepsy as late complications of postoperative hypoparathyroidism. 402 Mar 89

A man became ill with insufficiency of parathyroid glands 10 years after strumectomy. Numerous brain organic changes were apparent (severe epileptic seizures, tonic seizures of the brain stem, pathological EEG, PEG and liquor symptoms, papilledema, marked mental disturbances ranging in severity up to episodic psychoses), but even at the climax of the illness there were no definite signs of tetanic seizures, so that the basic illness remained unidentified for several months. Chronic secondary hypoparathyroidism was not definitely identified until ectodermal changes appeared, the characteristic changes of the lens contributing greatly to final diagnosis.
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PMID:[Significant manifestations and diagnostic difficulties in chronic secondary hypoparathyroidism]. 642 3

The present authors observed and treated a siblings case of normocalcemic tetany, which is considered as belonging to Bartter's syndrome. As far as we know, there are a number of familial cases of tetany in literature, but none of them spreads over more than two generations, so that the tetany appears to be recessive in hereditary characters including our patients. Both of them presented tetanic seizures in the course of Bartter's syndrome and they were regarded as one of various manifestations of the syndrome. In other words, the Bartter's syndrome or the hypopotassemia should be one of the fundamental disorders for developing tetanic symptom. The tetanic symptoms became extinct during the treatment with spironolactone against hypopotassemia. Of the two patients, younger sister had shown an agitated depression developed on her childish and over-sensitive personality, but the depression was improved in parallel to the recovery from tetany and hypopotassemia. Therefore, it appears to be certain that the patients would have some premorbid deviation of personality traits, where symptomatic psychoses could be attributed, in the case of Bartter's syndrome. Generally speaking the psychic disorders, such as personality deviation and psychotic episode, seem to by very important symptoms in patient with Bartter's syndrome as well as in patient with hypocalcemia or hypoparathyroidism.
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PMID:[Development of tetany in siblings suffered from Bartter's syndrome]. 649 22

A 73-year-old woman with hypoparathyroidism and hypocalcemic seizures was treated successfully with intravenous calcium. These symptoms developed 19 years after thyroid surgery. Prior to this admission, there had been many opportunities to make the diagnosis, had it been considered. Chronic hypocalcemia and hypoparathyroidism may present with varying signs and symptoms.
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PMID:Hypoparathyroidism: an unusual cause of seizures. 662 84

Hypoparathyroidism (hypocalcemia, hyperphosphatemia, mild hypomagnesemia, and inappropriately low serum C-terminal parathyroid hormone concentration) was found in six members of a family representing three successive generations. No patient had aortic arch or conotruncal malformations, lymphopenia, or features of type I or type II autoimmune polyglandular syndromes. Two individuals had transient neonatal seizures without further difficulties despite persistent hypocalcemia. None of the four affected adults has had major complications of hypoparathyroidism (mental retardation, cataracts, or seizures). We believe that persistence of hypoparathyroidism after resolution of neonatal hypocalcemic seizures should prompt a survey of the family for hypoparathyroidism.
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PMID:Autosomal dominant hypoparathyroidism with variable, age-dependent severity. 688 2

The course of a successful pregnancy in a kidney transplant recipient suffering from hypoparathyroidism is reported. The infant, born at 34 weeks' gestation, had normocalcemia and transient hyperparathyroidism. Maternal hypocalcemic attacks are liable to occur in the third trimester. Close observation with adequate supplements of calcium and vitamin D derivatives are required. Enhancement of fetal lung maturation and early delivery are advocated as effective treatment for the increasing frequency of hypocalcemic seizures.
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PMID:Association of hypoparathyroidism and successful pregnancy in kidney transplant recipient. 704 37

A review of computed tomograms (CT) of 7,120 patients demonstrated bilateral basal ganglia calcifications in 17. Skull roentgenograms were normal in all patients. Seven patients (41%) were older than 50 years of age with no basal ganglia dysfunction and metabolic abnormalities. Therefore it was thought that they may represent the senescent calcification. The second largest group was idiopathic hypoparathyroidism. These five patients (29%) were 16 to 32 years of age, had convulsive seizures and widespread calcifications. The other five patients had various symptomatology. Hypoparathyroidism should be investigated in young patients, if they have convulsive seizures and widespread basal ganglia calcifications on CT.
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PMID:Calcification of the basal ganglia on computed tomography. 716 97

We report one case of amicrobic pustulosis cured with Dedrogyl (25-hydroxycholecalciferol), active metabolite of the vitamin D. The importance of our case stems from the physiopathologic study of this cure. The patient is a 16-year-old boy suffering from a hypoparathyroidism since his younger days. Consequently, he shows a hypocalcemia and convulsive seizures due to the hypoparathyroidism. Those seizures had been wrongly attributed to a primary epilepsy of a neurologic origin and a treatment with Phenobarbital had been instituted. In fact, they were side-effects of the hypoparathyroidism and the Phenobarbital had only aggravated the hypoparathyroidal hypocalcemia as a result of its effect on the metabolism of the vitamin D (deviation of this metabolism by enzyme induction at the level of the liver). The Dedrogyl (25-hydroxycholecalciferol) has restored a normal phospho-calcium balance and the hypocalcemia has disappeared as well as the convulsive seizures which, one year later, had not reappeared while they had previously been continual. And above all, standing back one year, we have recorded a complete cure of the amicrobic pustulosis on account of the Dedrogyl.
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PMID:[Amicrobic pustulosis hypoparathyroidism epilepsy: treatment by 25-hydroxycholecalciferol]. 723 92

Two cases of calcification of Striopallidodentate System will be considered. The first refers to a 20-years-old patient and features two small bilateral and symmetrical calcifications in the medial segment of globus pallidum. The first symptom, observed from the age 5 years was, behaviour disorder and, some years later, dystonia. The second case refers to a 54-years-old patient and features huge bilateral and symmetrical calcifications above and below the tentorium. The first symptoms started at the age of 32 with paraesthesiae and muscular contractions of the upper limbs, later with convulsive seizures and tetany and eventually right hemiplegia with aphasia. Study of Ca and P metabolism showed normoparathyroidism in the first case and idiopathic hypoparathyroidism in the second.
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PMID:[Striopallidodentate calcifications. Report of two cases (author's transl)]. 734 49


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