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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient with new onset seizures was found to have radiographic findings of a calvarial hemangioma. Because of the history, additional diagnostic tests were employed, which excluded cerebral lesions. Findings characteristic of hemangioma on blood pool imaging were felt to confirm the diagnosis.
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PMID:Radionuclide blood pool imaging of calvarial hemangioma. 622 63

A 13-year-old girl suffering from seizures who was found to have hemangioma calcificans in the frontal lobe was surgically treated. The favorable postoperative course of our patient as well as reported cases suggest early excision of the lesion if it is located in an accessible area. Histological examination confirmed ossification with marrow in the lesion. The literature regarding ossification in the brain is discussed briefly.
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PMID:Cavernous hemangioma with bone formation in a child: case report. 642 47

A series of 15 angiographically cryptic, histologically proved, cerebrovascular malformations occurred. Nine patients were admitted to the hospital with evidence of recent neurological deterioration or onset of headache. Six patients had convulsions. Computed tomographic scan and surgical exploration disclosed a substantial cerebral hematoma in eight instances. The pathological diagnosis was arteriovenous malformation in 11 cases, cavernous angioma in three, and venous angioma in one. Histological evidence of previous microhemorrhage was present in the majority of the specimens, including the patients who had seizures. A change in neurological status or onset of seizures probably indicates recent hemorrhage in cryptic cerebrovascular malformations.
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PMID:Hemorrhage and epilepsy in cryptic cerebrovascular malformations. 674 62

Our clinical and surgical experience with 16 cases of cavernous hemangioma (cavernoma) of the brain is presented. In 50% of the cases, symptoms appeared during the 3rd decade of life. The clinical picture included seizures in 50% of the cases and a brain tumor-like syndrome in 37.5%, and 12.5% of the cases began with an intracerebral hemorrhage. In our series females predominated over males by 2:1. Computed tomographic (CT) scanning is the best procedure for the diagnosis of cavernomas. However, exact preoperative diagnosis of these lesions is infrequent because cavernomas are generally accepted to be very rare. A slightly hyperdense nodule, poorly enhanced after contrast administration, is the prominent feature on the CT scan. A small, hypodense zone surrounding the lesion and calcifications within the nodule are also found. An excellent result after operation was obtained in all cases of cavernoma located in the brain hemispheres. In deeply placed cavernomas (basal ganglia or brain stem), the surgical prognosis is doubtful, and features such as the size of the lesion and its anatomical location are important.
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PMID:Cavernomas of the brain. 683 2

This 9-year-old boy had two circular areas of aplasia congenita of the scalp in the territory of the first division of the trigeminal nerve and an ipsilateral parieto-occipital leptomeningeal capillary venous angioma. He had an associated giant aneurysm of the distal posterior cerebral artery on the same side as the vascular malformation. The patient had a long history of seizures and presented with intracerebral bleeding. This case may be considered as a variant of Sturge-Weber syndrome. Further observations must be added to consider this entity as a separate neurocutaneous disease.
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PMID:Leptomeningeal angiomatosis and aplasia congenita of the scalp. Case report. 685 88

In a kindred of 122 individuals we found 5 individuals with cerebral vascular malformation, 3 representing typical cavernous angiomas. The condition was inherited as an autosomal dominant trait with variable expressivity. Forty-three relatives were examined prospectively by cranial computed tomography (CCT) and lesions were found in 15; 7 were followed prospectively with CCT scans for 5 years. Angiography in 5 of these cases failed to demonstrate the lesion. In 3 patients with previously normal CCT scans a change in blood volume or membrane permeability allowed visualization of the lesion on contrast scans. In 2 individuals, both parents of affected children, a normal CCT scan was found. This emphasizes the limitations of CCT in detecting this disorder. Biochemical and red blood cell immunological genetic linkage studies were done in 36 persons. No linkage was found with any of the markers. The natural history of this disorder, characterized by marked clinical and radiographic variation in site of lesion, and the timing and severity of intracranial hemorrhage, make it a useful model for investigating contributing factors and consequences of intracranial hemorrhage in general. For at-risk and affected patients early and sequential CCTs are necessary. Familial cavernous angioma should be included in the differential diagnosis of all young persons presenting with cerebrovascular impairment, seizures, intracranial calcifications or hemorrhage.
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PMID:Familial cavernous angiomas: natural history and genetic study over a 5-year period. 695 Jun 64

Histopathological studies were carried out on temporal lobe tissue from 25 patients with partial complex seizures who were studied by interictal positron computed tomography (PCT) with 18F-fluorodeoxyglucose and subsequently underwent anterior temporal lobe resection. Abnormalities were identified on x-ray computed tomographic scans in 7 patients, but none indicated the site of a pathologically confirmed structural lesion. Hypometabolic zones were observed on PCT scans of 22 patients and corresponded to focal pathological abnormalities in 19 (15 mesial temporal sclerosis, 2 small neoplasms, 1 angioma, 1 heterotopia). In 1 patient with a focally abnormal PCT scan and no pathological changes, the lesion may have been located posterior to the resection. In the remaining 2 patients, the hypometabolic zones later disappeared and may have represented a transient response induced by depth electrode implantation. Three patients with normal PCT scans had no pathological abnormalities in their resected tissue. The degree of relative hypometabolism measured by PCT correlated well with the severity of the pathological lesion, but the size of the hypometabolic zone was generally much larger than the area of pathological involvement. This discrepancy could not be considered an artifact of technique and must represent either structural abnormalities below the resolution of routine histopathological studies (e.g., loss of synapses) or functional inactivation of neuronal elements associated with the epileptogenic lesion.
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PMID:Pathological findings underlying focal temporal lobe hypometabolism in partial epilepsy. 698 18

A 32-year-old male, who had had temporal lobe seizure for the past 10 years, was admitted to the neurosurgical institute of Tenri Hospital on March 10, 1981. Physical examination on admission revealed some memory disturbance, neuroasthenic tendency and a purplish nevus in the left foot. Plain x-ray series of the skull showed several nodular calcified lesions in the medial aspect of the left temporal lobe. Electroencephalography showed sporadic negative spikes and irregular slow waves dominant in the left anterior quadrant of the head. CT scan showed a high-density area in the left hippocampal gyrus with slight enhancement by contrast medium. Under stereotactic consideration, a left temporal osteoplastic craniotomy and total removal of the mass were performed on March 20, 1981. The histological examination proved it to be calcified cavernous hemangioma or hemangioma calcificans after Penfield and Ward (1948). Postoperative course was uneventful; even 4 weeks after surgery, electroencephalogram became normalized, and memory and anxiety scores became better. At present, in spite of decreased anticonvulsant, the patient has had no more seizure since surgery, and has returned to his business without any complaint. The authors have emphasized the necessity of active operation for hemangioma calcificans even for the one located in the depth of the dominant cerebral hemisphere. Stereotactic consideration can make the surgical risk minimize. CT scan especially with its contour plot of the images is helpful precisely to locate the lesion. For the nevus in the left foot, the biopsy was refused by the patient, which might have connection with the intracerebral cavernous angioma.
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PMID:[A case of hemangioma calcificans (author's transl)]. 704 21

Only four cases of chaismal syndromes caused by arteriovenous malformations (AVMs) have been reported. We have examined two patients with chiasmal dysfunction caused by an AVM. In one patient, the AVM was suspected only after angiography. However, the presence of an angioma of the lip might have been a clue to the diagnosis. In the other patient, seizures and pulsating proptosis led to the correct diagnosis before angiography was performed. This patient also had episodes of transient bilateral blindness, presumably caused by postictal states or by periodic shunting with ischemia (chiasmal steal).
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PMID:Chiasmal syndrome caused by arteriovenous malformations. 706 62

Twelve cases of venous angioma of the brain are presented. The neuroradiological and clinical findings in our series as well as in 45 previously reported cases are summarized. Angiography shows a normal arterial phase but consecutively a network or medusa-like pattern of numerous dilated medullary veins. converging towards one or several draining vessels with transcerebral course. The angiographic appearance is characteristic but not uniform, showing subgroups with faint blush, early filling veins and drainage into different directions. Some cases of venous malformations cannot be classified on the basis of angiographic findings and differentiation of telangiectases or cavernomas may be difficult. CT findings are non-specific, but contrast-enhanced CT almost invariably shows an enlarged transcerebral vessel, suggesting the presence of venous malformation. The lesion has to be classified as a vascular hamartoma. Although not an uncommon finding at autopsy venous angioma has been considered rare, because its clinical and radiological characteristics are little known. Though it may be asymptomatic, more than 30% of the reported cases (50% in our series) suffered from epileptic seizures. In about 10% of all cases symptoms of intracranial hemorrhage related to venous angioma were observed.
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PMID:[Neuroradiology, clinical picture and pathology of cerebral venous angiomas]. 713 21


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