Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a consecutive material comprising 43 alcoholics immediately prior to pension, due to their abuse, the interrelations between different symptoms of dysfunction of the brain and liver were studied. Signs of brain damage used were: psychometric test, delirium tremens and withdrawal seizures. Liver disease was examined by biopsy and liver function tests. The signs of dysfunction were compared with drinking pattern, amount of alcohol consumption and duration of abuse. The group was fairly homogeneous with respect to these variables. The patients showed a considerable degree of brain and liver damage, but relevant significant correlations between the criteria of brain and liver disease could not be demonstrated. This may support the hypothesis that the brain and the liver, in the same individual, react differently to alcohol.
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PMID:Do brain damage and liver disease interrelate in advanced abusers of alcohol? 666 41

Seizures and delirium tremens were recorded among 292 randomly selected patients admitted to an in-patient alcoholism program. Despite the almost routine prophylactic use of anticonvulsant and sedative drugs the incidence of seizures and delirium tremens during detoxification in hospital was 3%. However, as most alcohol withdrawal seizures occurred immediately before admission, the overall seizure incidence was higher (10%). Those patients who developed seizures during detoxification admitted previous abuse of benzodiazepines or erratic use of phenytoin. The results suggest that prescribing of anticonvulsants to alcoholics may increase their seizure problems, because they are prone to erratic drug taking, and because of drug-alcohol interactions, increased drug metabolism and abuse of the sedative anticonvulsants.
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PMID:Should alcohol withdrawal seizures be treated with anti-epileptic drugs? 670 19

Before treatment 80 unselected patients suffering from delirium tremens were examined with regard to 13 psychopathological criteria. For the data a matrix of correlation was computed and it was factor analyzed according to the principal-component method. In consideration of the course of the value-curve two factors were interpreted. The result, however, is an undetailed classification. In addition to that, the data were cluster-analyzed according Ward. The results of the multivariate statistical analysis admit the assumption of two great, though heterogenous groups of symptoms (hallucination/vigilance). Factor I comprises the symptoms, disorder of orientation and consciousness, sweating, agitation and tremor on its positive pole, the duration of the delirant state on its negative pole. Factor II combines paranoid-hallucinatory symptoms, fearful affects and suggestibility on its positive pole, while on its negative, there are happy affect and grand-mal seizures. The bipolarity of this factor and additional diagnoses show that paranoid-hallucinatory symptoms without disorder of consciousness and grand-mal seizures mutually exclude each other. From this a differential therapy treating patients suffering from paranoid-hallucinatory symptoms with neuroleptics (e.g. Haloperidol) can be deduced, while the danger of grand-mal seizures has to be considered when disorders of consciousness appear.
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PMID:[Principle factors and symptom complexes in delirium tremens, factor and a group analytic study]. 717 1

Alcohol intoxication was detected in the immediate history of 277 (49%) of the 560 consecutive seizure patients brought to the emergency room of Meilahti hospital in Helsinki during the course of a year, most of these patients being young men of working age. The alcohol-provoked seizures occurred mainly on Sunday and Monday, following the weekly pattern of alcohol consumption in Finland, and preceded delirium tremens in 21 patients (4%). Even short periods of intoxication (1-2 days) provoked seizures. The data indicate that among patients with a previous history of recurrent alcohol-withdrawal seizures, new treatable diseases of the CNS, especially acute brain injuries, are frequently encountered. Therefore, all seizure problems, not neglecting those of alcoholics, should be carefully examined.
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PMID:Occurrence of cerebral seizures provoked by alcohol abuse. 741 63

Ninety-five patients undergoing early alcohol withdrawal were observed for a five-day period in a non-hospital facility to evaluate the natural history of blood pressure change during this period. Patients under 30 years old developed a significant increase in systolic pressure on the second abstinent day, decreasing a mean of 10 mm Hg by the fourth abstinent day. With increasing age there was a progressively smaller rise in systolic pressure. Multivariate analysis showed a history of hypertension, delirium tremens, seizures, initial pulse, race, and sex not to be predictive of blood pressure change. Diastolic pressure was unaffected. Etiology of this difference requires further study. There were no hypertensive complications in this group. Patients undergoing early withdrawal need not be treated for changes in blood pressure without evidence of end organ damage or severe hypertension.
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PMID:Evaluation of blood pressure during early alcohol withdrawal. 745 29

A survey of 100 consecutive admissions for alcohol abuse in 1990 highlights the severity of alcohol dependence in the East End of Glasgow. The survey identifies a specific sub-group of heavy drinkers who consume strong lager, usually in open spaces, referred to locally as 'garden parties'. In the total population, males outnumbered females 3:1 with a mean consumption of 268 and 230 units of alcohol per week, respectively. The severity of alcohol abuse was reflected in their social, physical and central nervous system complications. Two-thirds of the population had a family history of alcohol abuse. Over three-quarters of the population showed self neglect with nearly half the males ascribing their marital breakdown or family neglect directly to their drinking problem. Both sexes showed a high prevalence of history of paraesthesiae, while half the male population had clear signs of peripheral neuropathy on admission. A history of delirium tremens in over 50% of the population with a history of seizures in 21% of males and 35% of females indicates central nervous system involvement. Three sub-groups were identified: history of delirium tremens, history of persecutory ideation and history of serious criminality. All three sub-groups had a shorter length of drinking with higher consumption and increased frequency of 'garden parties' than the group as a whole. This survey reinforces the need for appropriate in-patient detoxification and rehabilitation facilities for patients with severe alcohol dependence, to reduce their impact on other health, social work and criminal justice services.
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PMID:Severity of alcohol dependence in the East End of Glasgow. 774 78

Many patients experience withdrawal because an acute illness has interrupted their usual alcohol intake. Medical and psychiatric complications of alcoholism may also coexist with withdrawal. Several findings predict the likelihood of seizures of delirium tremens and thus are useful in making initial treatment decisions.
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PMID:Recognition and management of occult alcohol withdrawal. 755 29

A study of 72 alcoholics, hospitalized for alcohol withdrawal syndrome, was undertaken to determine the incidence of seizures, their relationship with other withdrawal symptoms, the presence of brain atrophy and the relationship of this last with withdrawal intensity severity. Sixty-seven (93%) were male and the mean age was 44.9 +/- 1.3 (mean +/- SEM) years. Thirty-three (46%) of the 72 patients had seizures at admission, 10 of these developed minor withdrawal symptoms, in 18 delirium tremens ensued and 5 showed no symptoms of withdrawal. Thirty-nine (54%) had withdrawal syndrome without seizures. Twenty-one of these developed minor withdrawal syndrome and 18 delirium tremens. Seizures showed no relationship with the other withdrawal manifestations, and in all the cases preceded them. Our findings also show that alcoholics with seizures due to withdrawal are more prone to suffer seizures in their future withdrawal episodes, and that alcoholics who suffer morning withdrawal symptoms are prone to develop delirium tremens. In 46 patients a CT scan was performed. Though the alcoholics showed ventricular and sulcal enlargement, brain atrophy was similar when the seizure and non-seizure groups or those with and without delirium tremens were compared. However, cortical and ventricular atrophy were related to the existence of previous episodes of withdrawal syndrome [corrected].
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PMID:Alcoholic withdrawal syndrome and seizures. 794 73

delta-Aminolevulinic acid dehydratase (ALAD) is the second enzyme in the heme biosynthetic pathway and catalyzes two molecules of delta-aminolevulinate (ALA), which is a potent agonist for GABA autoreceptors. ALAD has two common alleles and thus consists of three distinct isozymes, designated 1-1, 1-2, and 2-2. It has been shown recently that ALAD1 allele is associated with alcoholic liver injury. This association was ascribed to possible differences among isozymes in sensitivity to oxidized glutathione (GSSG), and this sensitivity is increased in erythrocytes of alcoholic patients. In the present study we measured erythrocyte ALAD activity from subjects with different ALAD genotype and found ALAD-1 is most sensitive to GSSG. We then investigated allele frequencies of ALAD in alcoholics (n = 126) and healthy controls (n = 115). For the control group, the frequencies were 0.94 (ALAD1) and 0.06 (ALAD2) and for the overall alcoholic group, 0.91 (ALAD1) and 0.09 (ALAD2). There were no significant differences in allele frequencies at the ALAD locus between the two groups. Subtyping the alcoholics according to the presence or absence of delirium tremens, hallucinosis, withdrawal seizure or liver cirrhosis failed to show statistically significant differences in the allele frequencies. We conclude that our data do not support the evidence of an allelic association between the ALAD1 and alcoholism.
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PMID:[Lack of association between alcoholism and alleles in the delta-aminolevulinic acid dehydratase (ALAD) gene]. 808 Apr

Hundreds of thousands of significant alcohol withdrawal episodes are encountered by primary care physicians every year. If the situation is appreciated at an early stage, most patients can be managed successfully on an outpatient basis with benzodiazepines. Patients with seizures, concurrent medical illnesses and severe withdrawal signs should be hospitalized. Fewer than 5 percent of patients withdrawing from alcohol progress to delirium tremens. Mortality from delirium tremens has been reduced to less than 5 percent of patients, through early diagnosis, supportive nursing care, treatment of coexisting medical conditions and aggressive pharmacologic therapy. Patients with a history of multiple detoxification episodes are more likely to experience seizures and severe withdrawal symptoms.
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PMID:Alcohol withdrawal syndrome. 1099 25


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