Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036572 (seizures)
 80,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Haemophilus influenzae meningitis are frequent in Africa in infants between 6 months and two years of age. Type b is observed in 97% of cases. In Dakar, 2% of strains are resistant to ampicillin and 0% to chloramphenicol. Lethality is about 30% and sequellae are very frequent. Prognosis can be predicted by a cotation scale including consciousness, tonus, seizures, nutritional status, delay before treatment and initial bacterial antigen level in CSF.
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PMID:[Epidemiology and prognosis of Haemophilus influenzae meningitis in Africa (901 cases)]. 634 41

We studied chest radiological images in 69 patients with tuberculosis, 4 of them were affected by HIV-infection. The sex ratio was 2.63. We observed 177 abnormal pulmonary images associated in different ways. Bilateral and diffuse radiological signs were noted. Tubercular cavern was the most frequent image (92.90%). It corresponded to a clear circular and oval image surrounded with a regular wall. It can locate in lesional source or healthy parenchyme. Caverns size was situated between 10 to 80 mm. The reticular and nodular infiltration (69%) as indicated associated linear and micro-nodular images. Lobar pneumoniae (44.90%) and segmental pneumoniae (4.30%) corresponded to alveolar lesions showing an opaque and homogeneous tonality image limited by seizures. They were retractile (P = 0.015). Principal mediastinal signs were relative to the presence of adenopathies (11.6%) associated with pleuropulmonary images. Four patients (5.79%) presented tuberculosis association with positive HIV serology. These patients did not present any radiological particularity. They did not show mediastinal adenopathies aspects. Pleural images better corresponded to a localize pachypleurite (13 cas) than a liquid extravasation (8 cases).
Dakar Med 1996
PMID:[Pulmonary tuberculosis in adults: radiological aspects before starting treatment]. 982 5

The authors proceeded to a 7 month long prevalence survey on epilepsy in the schools of the regions of Dakar and Thies in Senegal, West africa. It consisted to a cross sectional descriptive study targeting the children between 3 and 10 years old. The W.H.O. questionnaire on epilepsy was used for data collection. Among the 2803 children of the population study, 58 were detected suffering from epilepsy, realizing a prevalence rate of 21%. The males were more represented (62% of the epilepsies). All the epileptic children presented generalized seizures represented either by "Grand Mal" generalized tonic-clonic form (84.4% of the epilepsies), or by "Petit Mal" absences (15.6% of the epilepsies). The etiological forms were dominated by idiopathic epilepsies. Secondary generalized cases represented 31% of the epilepsy and were essentially detected in rural areas. They were usually related to obstetrical traumas (61.1% of the secondary generalized epilepsies) or to child encephalopathy with seizure attacks (38.9% of the secondary generalized epilepsies). It appears also from this study that epilepsy remains a dramatic public health reality and is more frequent among low economy income people who have less access to the health care system.
Dakar Med 1999
PMID:[Neuroepidemiology of epilepsy in Senegalese school milieu]. 1079 96

Status epilepticus (SE) is a condition requiring emergency care, which is often poorly managed in developing countries due to the lack of personnel, drugs, and insufficient technical and medical means. This study aims at determining the epidemiologic and etiologic characteristics and the difficulty in treating SE under the existing medical practice conditions in a developing country such as Senegal. A retrospective study was therefore carried out based on SE medical files at the University Hospital of Dakar over the period January 1988 to December 1998, and included several hospital departments, i.e., paediatrics, infectious diseases and neurology. Over an 11-year period 697 cases were recorded; of these, 48.2% of patients were under 5 years of age. The seizures were generalized in 58.2% of cases, partial in 21.2%, partial secondarily generalized, or with an association of both clinical presentations in 20.6% of cases. The etiology was as follows: mainly infectious (67%), followed by resistant and/or unbalanced epilepsy (9.9%), epilepsy of vascular origin (8%), and various other causes. The overall mortality rate was 24.8%. A long period between the onset of clinical symptoms and hospital treatment was noted, with an average time lapse of 16.6 h before treatment. The drugs utilized were diazepam and phenobarbitol, administered by injection. The overall outcome could be improved by better management, i.e., better prevention and an efficient treatment of infectious diseases, a reduction in the time before treatment, and improved means of intensive care.
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PMID:[Treatment of status epilepticus in a developing country]. 1091 24

The authors described the first cases in Senegal (West Africa) of the association Parkinson's disease and epilepsy. Almost studies on this feature, stressed on their different pathophysiology basis epilepsy is related on excess of neuronal excitation, and Parkinson disease is an expression of lack of motor neuromodulation. The diagnosis has been done because of the coming out two seizures in the year on two patients one 59 years old and the other 70 years old experiencing Parkinson disease well documented before and treated. Biological study, ultrasonography and Doppler, CT Scan lead to rule out a vasculopathy. Good outcome with antiparkinsonian and anticonvulsant medications confirm the diagnosis.
Dakar Med 1999
PMID:[Anatomophysiologic and clinical study of the association of epilepsy and Parkinson's disease: apropos of 2 cases]. 1195 96

The realisation of a bridgework involves a direct action on the gingival marginal edge. It is submitted to peremptoriness of execution that one of the objectives is to respect the periodontium with a great rigour. In the opposite case it can become a greater aggression agent, source of prosthetic failures we carried out this report in order to evaluate in the framework of a pedagogic operational programme of crown and bridge prosthesis, the superficial periodontal risks linked to the preparation of the abutment teeth and to the prosthetic chain. We examined a randomised sample of 50 patients chosen from the Dakar LOS prosthetic consultation. On the periodontium initially sound we noted inflammatory lesions of the superficial periodontium from the beginning to the end of the treatment we used the Russel periodontal index. The whole individual scores summarised on a collective chart have been submitted to the statistical analysis of the independence by using the chi-square test. The population consulting in bridge work at the Dakar LOS is relatively young, 33 years in a average with a sex ratio of 1.17 and it shows a moderate (60% of the cases) and severe periodontal seizure (40% of the cases) dealing significantly with the type of prosthesis and the axial and occlusal morphology of the prosthesis pieces. This study shows that prosthesis rehabilitation in the frame work of a clinical training at the Dakar I.O.S. includes relatively high risks of periodontium aggression that we would minimise by setting more correctly the indications of the bridge work and by bringing more rigour to the record and the postpone of the patients occlusion in the laboratory conception of the prosthesis pieces.
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PMID:[Gingival risks of fixed prostheses at the Institute of Odontology and Stomatology of Dakar (I.O.S.)]. 1470 76

Epilepsy is one of the most common disorders encountered in children of developing countries. In Senegal, as in many other African countries, the disease is enrobed in superstition, discrimination, and stigma. There is a clear-cut lack of information programs in the developing world about seizures and epilepsy. Academic achievement of children with epilepsy is hampered by social barriers in addition to the burden of the disease and its treatment. The aim of this study was to evaluate teachers'knowledge, awareness, and current attitudes about epilepsy in order to obtain baseline data for the development of a school health education program on epilepsy. The study was carried out in Dakar. It was conducted by sending self-administered and anonymous questionnaires to 400 elementary school teachers; the data were randomly mapped, stratified, and chosen to produce a statistically representative sample of the teacher population of Dakar. The questionnaires contained 22 items related to knowledge of epilepsy, the attitude of teachers towards epilepsy, and their ability to provide first aid in case of seizures. A total of 373 teachers (93p.cent) completed the questionnaires. For 69p.cent, epilepsy arises in the brain, for 28.7p.cent it is a subnatural affliction. Epilepsy was considered to be contagious for 24p.cent and could be cured for 73p.cent. Although 66p.cent would help an epileptic pupil during a seizure, 53p.cent mentioned harmful measures. Eighty-four percent noticed that an epileptic child could go to a normal classroom, while 62.5p.cent would prefer a special school. Eighty-four percent said their knowledge on epilepsy was not sufficient and the majority (99p.cent) desired training on epilepsy. For 25.7p.cent, better collaboration between parents, doctors, and teachers would b helpful to achieve better management of epileptic children. This study demonstrated encouraging knowledge of teachers about epilepsy. However, some of their wrong attitudes may be attributed to superstitions and could be improved by informative actions and better training about epilepsy. Such education might be provided by local health professionals with the collaboration of parents, teachers, and non-governmental organizations.
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PMID:[A survey of school teachers' knowledge and behaviour about epilepsy, in a developing country such as Senegal]. 1503 47

The Objectives of this study were to Report a rare malformation and to try to understand the embryological origin of such lesion. We reported the case of an eight-month-old female infant, without any particular past medical history, who was refered for seizures and vomiting. The examination revealed normal anthropometric constants, a soft painless and renitent tumefaction of the vertex and a psychomotor delay. Skull x-ray showed a parietal lacuna opposite to an opacity. Ultrasound scan showed an encephalocystocele communicating with dilated ventricles. CT x-ray revealed a single ventricle with an important back and upper extension, which evokes a cystic formation of the centre line. The existence of this cystic formation suppose an agenesis of diencephalic and telencephalic structures notably commissural. Interest of such observation is in its rarity, its complexity, the possibility of its antenatal diagnosis and in the etiopathogenic discussions that she gives rise to.
Dakar Med 2003
PMID:[Commissural agenesis associated with inter hemispheric cyst]. 1577 43

Epilepsy is a significant health public problem in Senegal with an estimated prevalence of 8 to 14%. The aim of this study was to determine the clinical and electroencephalographic features of epilepsy in a cohort of Senegalese infants, search for etiological factors and determine the impact of disease on school life. This retrospective study concerned 459 children who attended the neurological outpatients clinic at the Fann hospital, Dakar, Senegal, between July 2003 and December 2006. All were aged under 19 years. Among the 135 children with idiopathic epilepsy, 23.7% had parental consanguinity and 37.77 % familial epilepsy. Rolandic epilepsy and epilepsy with absences were more frequent but several infants with idiopathic epilepsy were not classified. Non-idiopathic epilepsy was noted in 312 children. In this group, estimates of parental consanguinity and familial epilepsy were of 21.79 and 17.94%, respectively. Etiological factors were predominantly pregnancy and birth abnormalities (28.84%) and central nervous system infection (20.19%). Twelve children had febrile seizures. Of patients with idiopathic epilepsy, 65.18% were attending school versus only 9.29 with non-idiopathic epilepsy.
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PMID:[Epilepsy in a cohort of Senegalese children]. 1835 75

The objectives of this study were to study the prevalence of oral traumatisms and their relationship to epileptic seizures in Senegalese children. This study was undertaken in the Children's National Hospital of Dakar and deal with children with epilepsy. Sotf tissues and the teeth traumatisms that have occurred during epileptic seizures were recorded. We have also studied the relationship between the frequency of the seizures and the oral soft and hard tissues traumatisms. One hundred and eight children aged from 5 to 15 years with 67 boys and 41 girls with an average age of 8.16+/-2.86 years were enrolled. Several types of epileptic seizures were observed during which 44.5% of the children presented oral traumatisms of soft tissues (27.8%) and the teeth (16.7%). There is no significant relationship between the number of seizures and the frequency of the dental traumatisms (p = 0.352). The tooth fractures are the lesions most frequently noticed and are observed in 24.4% of the children. The traumatisms of the maxillary central incisors account for 38% of the traumatisms, followed by the canines (2.7%) and the molars (1.9%). The lower central incisors are the least affected. The traumatisms of soft tissues were observed in 27.8% of the children: the lips are more often affected (44%), followed by the tongue (30%), the association between lip and tongue (18%) and the cheeks (8%). There is no significant relationship between the number of seizures and the frequency of the traumatisms of soft tissues (p = 0.35).
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PMID:[Study of oro-dental injuries during seizures in Senegalese children with epilepsy]. 1836 30


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