Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036474 (scurvy)
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Human Gene/Protein
DEAR 13.2
gamma-butyrobetaine hydroxylase 9.9
PRDX4 9.8
peroxiredoxin 4 9.7
SVCT1 9.1
iron regulatory protein 1 8.6
myo-inositol oxygenase 8.4
Maltase 8.3
prolyl 4-hydroxylase 8.3
SVCT2 8.3
regucalcin 8.1
heme-binding protein 7.9
HSP47 7.8
lysyl hydroxylase 7.6
matrix metalloproteinase 1 7.2
Haptoglobin 7.1
hexokinase II 7.0
PFK 6.8
CDC25A 6.8
SGS 6.6
PHD2 6.6
aldehyde reductase 6.6
osteonectin 6.4
protein disulfide isomerase 6.4
hemopexin 6.4
fruitless 6.4
GRP94 6.3
CAST 6.3
TET1 6.3
MCT1 6.1
matrix Gla protein 6.1
glypican 6.1
transcobalamin II 6.0
Werner syndrome 5.9
leucine aminopeptidase 5.9
surfactant protein B 5.9
transporter 1 5.7
gamma-glutamylcysteine synthetase 5.6
ceruloplasmin 5.5
presenilin 1 5.4
FRE 5.3
P450scc 5.2
TPP 5.2
IGF-binding protein 5.2
CDK6 5.1
NRC 5.1
member 1 5.0
collagen 5.0
B12 5.0
GLUT1 5.0
IGFBP-1 5.0
solute carrier 4.9
pyrophosphatase 4.9
aconitase 4.8
HFE 4.8
haptoglobin 4.8
PLS 4.8
ACG 4.8
Ferritin 4.8
elastin 4.7
Laminin 4.6
Yes 4.6
heparan sulfate proteoglycan 4.6
serum amyloid A 4.5
Dakar 4.5
decorin 4.5
Aromatase 4.4
ASC 4.3
binding peptide 4.3
insulin-like growth factor 4.2
insulin-like growth factor-I 4.2
bax 4.2
enigma 4.2
IGFBP-3 4.2
GRP78 4.1
type II collagen 4.1
CHD 4.1
matrix metalloproteinase 2 4.0
aldose reductase 4.0
heme oxygenase-1 4.0
Lp(a) 4.0
proteoglycan 4.0
methemoglobin 4.0
CDK2 4.0
Rad 3.9
glucose-6-phosphatase 3.9
trip 3.9
factor VII 3.9
SCN 3.9
osteogenic 3.9
phosphofructokinase 3.8
osteopontin 3.8
cytochrome P-450 3.6
osteocalcin 3.6
muscle protein 3.6
NGF 3.6
CDK4 3.6
alkaline phosphatase 3.6
natural killer cell 3.5
ferritin 3.4
thromboplastin 3.4
galactosamine 3.4
microsomal 3.4
collagenase 3.3
hyaluronidase 3.3
erythropoietin 3.2
rat) 3.1
dystrophin 3.1
type I collagen 3.1
ART 3.1
cyclin-dependent kinase 3.1
FAD 3.1
interleukin 2 2.9
transferrin receptor 2.8
ACTH 2.8
chronic renal failure 2.8
brush border 2.8
housekeeping 2.7
lymphokine 2.7
endoplasmic reticulum 2.7
glucose transporter 2.7
twist 2.7
prothrombin 2.7
rhodopsin 2.7
colon carcinoma 2.6
STD 2.6
p27 2.6
oxidoreductase 2.5
transforming growth factor-beta 2.5
carp 2.5
VIII 2.5
anonymous 2.4
peroxisome proliferator-activated receptor 2.4
She 2.3
glucosamine 2.3
caspase-9 2.3
glutathione reductase 2.3
GSH 2.3
von Willebrand factor 2.2
keratin 2.2
IGF-I 2.2
aromatase 2.2
MRI 2.1
PARP 2.1
cyclooxygenase-2 2.0
Men 2.0
hemoglobin 1.9
proliferating cell nuclear antigen 1.8
tap 1.8
SARS 1.7
gut 1.7
mast cell 1.6
histone 1.6
growth hormone 1.6
albumin 1.6
interleukin-2 1.6
tyrosine hydroxylase 1.6
fibronectin 1.5
renin 1.4
amyloid precursor protein 1.4
more...
Disease
Acute paralytic poliomyelitis 15.5
scurvy 15.5
Vitamin depletion 14.5
vitamin C deficiency 13.9
Gingival hypertrophy 11.4
pellagra 11.3
cheilosis 11.0
beriberi 11.0
dysbasia 10.6
avitaminosis 10.6
Angular cheilitis 10.6
narcotic dependence 10.2
keratomalacia 10.1
Caffey's disease 10.1
hemeralopia 10.0
Hers 9.9
VDDR 9.7
Enamel hypoplasia 9.7
battered child syndrome 9.7
nervous disorder 9.6
polymenorrhea 9.6
xerophthalmia 9.5
hypovitaminosis 9.5
petechiae 9.5
paranoid personality disorder 9.5
Tauri 9.3
hypervitaminosis 9.1
rickets 9.1
gum disease 9.0
nutritional disorder 8.9
glossitis 8.7
polyneuritis 8.6
acrodermatitis enteropathica 8.6
dental abscess 8.6
Barlow 8.4
HMS 8.3
intertrigo 8.2
epiphysiolysis 8.2
microcolon 8.1
hemorrhagic diathesis 8.1
congenital syphilis 8.0
Growth failure 7.9
hyperkeratosis 7.9
paramyotonia 7.9
purpura 7.8
Kashin-Beck disease 7.7
RDA 7.7
marasmus 7.7
gingivitis 7.7
acrocyanosis 7.6
Whipple's disease 7.6
sicca syndrome 7.6
hyperostosis 7.6
periostitis 7.5
GSD I 7.5
kwashiorkor 7.4
Scheuermann's disease 7.4
Aleutian disease 7.3
enchondromatosis 7.3
hypophosphatasia 7.3
tyrosinemia 7.2
homocystinuria 7.2
Copper deficiency 7.2
oxalosis 7.1
dentinogenesis imperfecta 7.1
meningococcemia 7.0
epulis 7.0
Menkes 7.0
Franklin 7.0
myotonia congenita 7.0
Forbes 7.0
endarteritis 7.0
microcytic anemia 7.0
Albert 6.9
xerosis 6.9
vitamin A deficiency 6.8
siderosis 6.8
platelet disorder 6.7
Refsum disease 6.7
malnutrition 6.7
osteomalacia 6.7
night blindness 6.7
Ehlers-Danlos syndrome 6.6
paronychia 6.6
yaws 6.5
hemosiderosis 6.5
polyarthralgia 6.4
regional pain syndrome 6.4
dysentery 6.4
Zinc deficiency 6.3
macrocytic anemia 6.3
pyomyositis 6.3
McArdle's disease 6.3
prurigo 6.3
osteodystrophy 6.2
megaloblastic anemia 6.2
vitamin K deficiency 6.2
aphthous stomatitis 6.2
epiphysis 6.2
genetic hypertension 6.2
cheilitis 6.1
paranoia 6.1
hand-foot syndrome 6.1
seborrheic dermatitis 6.1
congenital hypothyroidism 6.1
Disorder 6.1
joint effusion 6.1
methylmalonic acidemia 6.1
cutis laxa 6.1
anguish 6.0
tooth loss 6.0
malabsorption 6.0
parotitis 5.9
rare disease 5.9
Wernicke's encephalopathy 5.9
scabies 5.9
galactosemia 5.8
corneal ulcer 5.8
myxedema 5.8
parakeratosis 5.8
failure to thrive 5.8
cerebral palsy 5.7
osteosclerosis 5.7
anorexia nervosa 5.7
rash 5.7
osteogenesis imperfecta 5.7
periodic paralysis 5.6
vitamin D deficiency 5.6
leeches 5.6
rheumatism 5.6
anemia 5.6
oral candidiasis 5.6
phobia 5.5
Ludwig 5.5
keratosis 5.5
Autism spectrum disorder 5.5
proptosis 5.5
chondrodysplasia 5.5
protein deficiency 5.5
periodontal disease 5.4
dermatitis herpetiformis 5.4
overnutrition 5.4
hysteria 5.4
thalassemia major 5.4
spondyloarthropathy 5.4
vitreous humor 5.4
Moore 5.4
folliculitis 5.3
refractory anemia 5.3
typhus 5.3
coronary thrombosis 5.3
iron deficiency 5.3
mucopolysaccharidosis 5.3
yellow fever 5.3
vasculitis 5.3
thiamine deficiency 5.2
hereditary hemochromatosis 5.2
bone disease 5.2
connective tissue disease 5.2
trachoma 5.2
more...
Symptom
Localized pain 10.8
strangury 10.4
onychomadesis 9.0
cardiovascular impairment 8.7
inanition 8.7
limb pain 8.1
halitosis 7.9
lassitude 7.4
bone pain 7.4
Physical findings 7.1
livedo 6.8
hyperesthesia 6.5
eds 6.5
asthenia 6.1
leg pain 6.1
rigors 5.8
lethargy 5.6
arthralgia 5.5
muscle rigidity 5.4
night sweats 5.3
dental pain 5.3
sore throat 5.1
myalgia 4.8
shortness of breath 4.7
hip pain 4.7
apathy 4.5
fever of unknown origin 4.5
weakness 4.4
thinning 4.4
fatigue 4.4
pallor 4.2
masculinization 4.2
paraparesis 4.1
anorexia 4.1
starvation 3.9
exertional dyspnea 3.8
Ill 3.6
cyanosis 3.6
chills 3.4
cachexia 3.0
collapse 3.0
diarrhea 3.0
agitation 2.9
hemoptysis 2.9
erythema 2.8
pain 2.6
nausea 2.6
chest pain 2.4
hypothermia 2.4
syncope 2.3
dyspnea 2.3
constipation 2.2
insomnia 2.1
vomiting 2.1
back pain 1.9
exhaustion 1.8
abdominal pain 1.6
ataxia 1.5
respiratory distress 1.2
cough 1.0
seizures 0.8
anesthesia -0.2
headache -0.3
Drug
ascorbate 9.3
Epoetin alfa 7.8
Epoetin alfa 7.3
Coumadin 7.1
Zoledronic acid 6.5
Camp 6.0
Zoledronic acid 5.9
Vitamin B12 5.2
Vitamin B 5.2
niacin 5.2
Vitamin K 5.0
Vitamin A 4.9
Dakar 4.4
vitamin E 4.4
Glutathione 4.1
Kenyan 3.7
Albumin 3.3
FAD 3.1
lysine 2.2
citric acid 2.2
Dial 2.2
Dermatol 2.0
Gel 1.6
Leaf 1.1
NADH 1.1
Cardiovasc -2.1
Enzyme
proline 3-hydroxylase 13.5
UDP-N-acetylglucosamine 4-epimerase 11.8
GLO 10.6
myo-inositol oxygenase 9.2
gamma-butyrobetaine hydroxylase 9.2
4-hydroxyphenylpyruvate dioxygenase 7.7
lactonase 7.7
sulfhydryl oxidase 7.6
lysyl hydroxylase 7.6
dehydroascorbate reductase 7.4
prolyl hydroxylase 6.7
aldehyde reductase 6.5
aldehyde reductase 6.5
aldehyde reductase 6.5
myrosinase 6.4
leucine aminopeptidase 5.8
caspase-7 5.7
caspase-7 5.7
interstitial collagenase 5.6
ceruloplasmin 5.5
sucrase 5.3
TPP 5.2
gamma-glutamylcysteine synthetase 5.0
TPP 5.0
aconitase 4.7
matrix metalloproteinase 2 4.3
invertase 4.2
CPR 4.2
asparaginase 4.1
demethylase 4.1
glucose-6-phosphatase 3.9
aldose reductase 3.8
phosphofructokinase 3.6
alkaline phosphatase 3.5
alpha-glucosidase 3.5
hyaluronidase 3.3
deaminase 3.2
diaphorase 3.0
collagenase 2.9
hyaluronidase 2.9
ribonuclease 2.8
ribonuclease 2.8
thromboplastin 2.8
caspase-9 2.6
succinate dehydrogenase 2.5
cytochrome oxidase 2.4
alcohol dehydrogenase 2.3
glutathione reductase 2.3
cholinesterase 1.9
PARP 1.8
beta-galactosidase 1.7
tyrosine hydroxylase 1.7
RNase 1.5
renin 1.4
RNase 1.4
trypsin 1.1
glutathione peroxidase 1.1
acetylcholinesterase 0.7
lactate dehydrogenase 0.7
superoxide dismutase 0.7
thrombin 0.5
caspase-3 0.4
focal adhesion kinase 0.1
catalase -0.3
ATPase -0.5
protein kinase -0.8
mitogen-activated protein kinase -1.0
Compound
L-Gulonolactone 12.9
Erythorbic acid 11.5
Benzanthrone 11.3
Salvarsan 10.2
Ascorbic acid 9.8
threonate 9.6
Lycorine 9.4
Pyridinoline 9.1
GDP-D-mannose 8.3
HMS 8.3
Dehydroascorbic acid 7.9
tridecane 7.8
4-hydroxyproline 7.7
4-hydroxyproline 7.7
4-hydroxyproline 7.7
4-hydroxyproline 7.7
4-hydroxyproline 7.7
4-hydroxyproline 7.7
trimethyllysine 7.5
hexuronic acid 7.5
hexuronic acid 7.4
hexuronic acid 7.4
hexuronic acid 7.4
Bantu 7.3
AAB 7.3
AAB 7.3
TET 7.2
TET 7.2
D-glucuronate 7.0
Ornithine 6.8
DPN 6.6
Hydroxyproline 6.4
D-glucuronic acid 6.2
Austin 6.1
Glutaraldehyde 5.6
2-oxoglutarate 5.5
Mendel 5.4
Collagen 5.4
Carnitine 5.3
Vitamin K 5.3
1,8-cineole 5.2
cinnamyl 5.1
TPP 5.1
Vitamin A 4.9
TPP 4.8
myricetin 4.7
proline 4.6
L-carnitine 4.6
nicotinic acid 4.4
Penicillin 4.4
TPP 4.3
Taurine 4.3
ASC 4.3
L-leucine 4.3
Methotrexate 4.2
phenazine 4.2
Warfarin 4.1
Penicillin 4.1
naphthoquinone 4.1
naphthoquinone 4.1
naphthoquinone 4.1
naphthoquinone 4.1
naphthoquinone 4.1
oxalic acid 4.1
oxalic acid 4.1
oxalic acid 4.1
oxalic acid 4.1
oxalic acid 4.1
oxalic acid 4.1
oxalic acid 4.1
oxalic acid 4.1
oxalic acid 4.1
oxalic acid 4.1
oxalic acid 4.1
oxalic acid 4.1
oxalic acid 4.1
oxalic acid 4.1
oxalic acid 4.1
naphthoquinone 4.1
oxalic acid 4.1
naphthoquinone 4.0
A 42 4.0
nicotinic acid 4.0
nicotinic acid 4.0
vitamin D 3.9
nicotinic acid 3.9
Quercetin 3.9
5-hydroxytryptophan 3.9
8-OHdG 3.8
Vitamin D 3.8
retinol 3.8
oxalic acid 3.8
SCN 3.7
Hemoglobin 3.7
iron 3.7
aniline 3.5
DHA 3.4
TCA 3.4
kaempferol 3.4
DHA 3.3
oxalate 3.2
hydroxylamine 3.1
FAD 3.1
His 3.1
hydroxylamine 3.0
butyric acid 3.0
hexose 3.0
hexose 3.0
hexose 3.0
UDP 2.9
butyric acid 2.9
PAS 2.9
COS 2.9
THF 2.9
ACTH 2.8
GalNAc 2.8
DHA 2.8
Lactate 2.8
butyric acid 2.7
GSH 2.7
GSH 2.7
prostaglandin E1 2.7
Adrenal 2.5
hexose 2.4
BCG 2.4
Sodium 2.3
aldehyde 2.3
zinc 2.2
iodine 2.2
Lead 2.2
Cholesterol 2.2
Tris 2.2
Estrogen 2.2
Dial 2.1
NADP 2.0
selenium 2.0
copper 2.0
homocysteine 2.0
tryptophan 2.0
tryptophan 2.0
TEM 2.0
tryptophan 1.9
aldosterone 1.9
aldehyde 1.9
GlcNAc 1.8
lysine 1.8
tryptophan 1.7
xylose 1.7
Thyroid 1.6
ASA 1.6
sulfate 1.5
salt 1.5
nicotinamide 1.5
Optimal 1.4
galactose 1.3
Ile 1.2
cGMP 1.1
acetone 1.1
NADH 1.1
retinoic acid 0.9
more...