Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0036474 (
scurvy
)
685
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The reduced form of vitamin C, ascorbic acid, is well known for its function as an antioxidant and as a protective agent against
scurvy
. However, many recent studies indicate other functions for vitamin C in mammalian cells. Novel findings provide possible explanations for observed beneficial effects of a high intake of vitamin C on cell growth, gene transcription, host resistance to infection, uptake of polyamines and clearance of misfolded proteins. Vitamin C exerts its effects indirectly via hypoxia-inducible factor, nitric oxide synthase and the
heparan sulfate proteoglycan
glypican-1, which is deglycanated in a vitamin C- and copper-dependent reaction.
...
PMID:Novel aspects of vitamin C: how important is glypican-1 recycling? 1734 97
