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Query: UMLS:C0036474 (scurvy)
 685 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Scurvy, a disease of dietary deficiency of vitamin C, is uncommon today. Among diseases, scurvy has a rich history and an ancient past. The Renaissance (14th to 16th centuries) witnessed several epidemics of scurvy among sea voyagers. In 1747, James Lind, a British Naval surgeon, performed a carefully designed clinical trial and concluded that oranges and lemons had the most antiscorbutic effect. Eventually, with the provision of lemon juice to the sea voyagers, scurvy became rare at sea. Infantile scurvy appeared almost as a new disease toward the end of the 19th century. The increased incidence of infantile scurvy during that period was attributed to the usage of heated milk and proprietary foods. Thomas Barlow described the classic clinical and pathologic features of infantile scurvy in 1883. Between 1907 and 1912, Holst and Frolich induced and cured scurvy in guinea pigs by dietary modification. In 1914, Alfred Hess established that pasteurization reduced the antiscorbutic value of milk and recommended supplementation of fresh fruit and vegetable juices to prevent scurvy. Such pioneering efforts led to the eradication of infantile scurvy in the United States. A brief history of infantile scurvy is provided.
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PMID:Infantile scurvy: a historical perspective. 1158 84

The classical form of Barlow's disease or infantile scurvy, with bruises, broken bones and sores that will not heal, is rarely seen today, but it seems to be reappearing under a different guise, when infants with borderline vitamin C depletion are assaulted with too many inoculations at one time.Moreover, it is now sometimes mistakenly diagnosed as child abuse.
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PMID:Barlow's disease. 1216 Jun 80

1. Pronounced cases of Barlow's disease may be produced in the fetus as early as ten to fifteen days after the commencement of dieting pregnant guinea pigs with oats and water. There are wide individual variations. The scorbutic changes in the skeleton are greatest in the earlier embryonic stages. The fetuses of that period, with practically no exceptions, die and show marked traces of impeded growth. 2. Fetuses from the later period of pregnancy are born alive, and apparently fully developed, with comparatively slight changes in the osseous system. 3. Even a short extension of the period of extra-uterine dieting on milk from scorbutic mothers and later on oats and water is sufficient to change the latent scurvy into a highly pronounced case. 4. The fetus cannot be kept alive longer than the adult animal, about twenty-eight days, either by intra-uterine dieting alone or by combined intra- and extra-uterine dieting. 5. The mothers show signs of disease at an early period, and are more severely attacked than non-pregnant animals. Death also occurs comparatively often in the first period of gestation.
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PMID:A STUDY OF BARLOW'S DISEASE EXPERIMENTALLY PRODUCED IN FETAL AND NEW-BORN GUINEA PIGS. 1986 88