Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036421 (PSS)
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Human Gene/Protein
PSS 11.5
prostaglandin I2 (prostacyclin) receptor 11.5
SAMD3 10.5
Kelch-like protein 7 10.5
HLA-DQB1 chain 10.5
PM-Scl 10.2
NAG-2 9.9
OCTD 9.9
ODF3B 9.9
platelet receptor for type III collagen 9.9
Kelch-like protein 12 9.5
C8orf13 9.5
p25beta 9.5
CHST13 9.5
Phospholipase D4 9.3
CREST 9.3
OTUD6B 9.2
PSD3 9.2
cornea-derived transcript 6 9.2
PEM2 9.2
PXK 9.1
CD247 9.0
SNAP1 8.9
ZBTB3 8.9
UDP-D-xylose:core protein xylosyltransferase 8.9
IL1R3 8.9
VII-5 8.9
UTP14A 8.9
POLR1B 8.7
B2GPI 8.7
LRP2BP 8.7
SCHIP1 8.6
IGFL2 8.5
SSR4 8.5
TREH 8.5
U1-70K 8.4
U11/U12 8.4
IFIX 8.3
CMTM2 8.2
SAMD4A 8.2
CMTM1 8.2
PS21 8.2
RPC1 8.2
CD11A 8.2
AARD 8.2
muscarinic acetylcholine receptor M3 8.1
Monad 8.0
PTP4A2 8.0
EXOC2 8.0
KIR2DL5B 7.9
COL22A1 7.9
LRRC16A 7.9
LW-1 7.9
IL1RAPL2 7.8
Friend leukemia virus integration 1 7.8
XT2 7.7
DNASE1L3 7.7
CMTM5 7.7
KIAA0319L 7.7
ZNF41 7.7
TNPO3 7.7
phospholipase D3 7.7
TMEM175 7.7
Insulin-like growth factor-binding protein 5 7.7
XT-I 7.6
XYLT2 7.6
BANK1 7.6
CENP-B 7.6
CMTM3 7.6
LysoPLD 7.6
DOK5 7.6
FLI 7.6
PAH 7.5
cartilage glycoprotein-39 7.5
FAM167A 7.5
CMTM4 7.5
PHS2 7.5
NAG2 7.5
hnRNPC 7.4
DNA topoisomerase 1 7.4
more...
Disease
Lung involvement in systemic sclerosis 11.5
Idiopathic (IPAH) 11.5
PSS 11.5
syndrome; cervical 11.5
Nonspecific esophageal motility disorder 11.5
PSS 11.5
Hollow visceral myopathy 11.5
Autoimmune skin disease 11.5
PSS 11.5
Systemic sclerosis sine scleroderma 11.3
Scleroderma renal crisis 11.2
Limited cutaneous systemic sclerosis 10.9
Pseudoscleroderma 10.9
renal scleroderma 10.7
diffuse scleroderma 10.7
Juvenile scleroderma 10.5
Alezzandrini syndrome 10.5
Sinus node fibrosis 10.5
Secondary Raynaud's phenomenon 10.5
Acute intestinal pseudo-obstruction 10.5
sclerodactyly 10.5
scleroderma 10.0
oropharyngeal disorder 9.9
Sarcoid myopathy 9.9
Diffuse infiltrative lung disease 9.9
OCTD 9.9
Focal vasculitis 9.9
CHCL 9.9
localized scleroderma 9.9
CREST 9.7
Raynaud's phenomenon 9.7
mixed connective tissue disease 9.7
EGMA 9.6
Diffuse pulmonary fibrosis 9.5
Generalized morphea 9.5
Disorders of pigmentation 9.5
Familial visceral myopathy 9.5
CRST syndrome 9.4
Skin induration 9.3
morphea 9.3
Plaque morphea 9.2
Undifferentiated connective tissue disease 9.2
Raynaud 9.2
Trigeminal neuropathy 9.1
Eosinophilic fasciitis 9.1
connective tissue disease 9.1
esophageal dysmotility 9.1
pleurisy with effusion 8.9
Streptococcal bacteremia 8.9
Renal vascular disease 8.9
Thibierge-Weissenbach syndrome 8.9
Traction bronchiectasis 8.9
Erosive osteoarthritis 8.8
Eosinophilia myalgia syndrome 8.8
Alveolitis 8.8
Conduction system abnormalities 8.7
scleredema 8.6
Amegakaryocytic thrombocytopenia 8.5
Oxalate nephropathy 8.5
Gastric antral vascular ectasia 8.5
Parotid enlargement 8.4
collagen disease 8.4
Calcinosis cutis 8.3
Blue toe syndrome 8.3
Acute nephritis 8.3
Restrictive lung disease 8.3
calcinosis 8.3
dermatomyositis 8.3
collagen disease 8.2
Pulmonary renal syndrome 8.2
Protein-losing gastroenteropathy 8.2
interstitial lung disease 8.2
polymyositis 8.1
acroosteolysis 8.1
Chronic radiodermatitis 8.0
Necrotizing arteritis 8.0
Sjogren's syndrome 7.9
scleromyxedema 7.9
Secondary osteoarthritis 7.9
Renal vasculitis 7.9
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Symptom
Red face 10.5
Skin thickening 9.4
Auspitz's sign 9.2
Subungual hyperkeratosis 8.7
Retrosternal pain 7.5
vaginal discomfort 7.0
skin impairment 7.0
Urinary symptoms 6.8
ischuria 6.8
S3 gallop 6.4
reproductive problem 6.4
polymyalgia 6.2
musculoskeletal impairment 6.1
Lower urinary tract symptoms 6.0
cardiovascular impairment 5.7
Organ failure 5.5
painful swallowing 5.5
Skin symptoms 5.4
Signs and Symptoms 5.4
skin pain 5.3
heartburn 5.2
Overlying 5.1
peau d'orange 5.0
arthralgia 4.9
trigeminy 4.9
generalized abdominal pain 4.9
Gastrointestinal symptoms 4.9
generalized pain 4.9
Buckling 4.9
Musculoskeletal symptoms 4.8
astasia 4.6
livedo 4.6
facial droop 4.5
exertional dyspnea 4.4
prostatism 4.3
dry eye 4.3
myalgia 4.3
bloating 4.3
menometrorrhagia 4.2
acid regurgitation 4.1
scaly skin 4.1
clubbing 4.0
Neurologic symptoms 4.0
dry skin 3.8
abdominal fullness 3.8
dyspnea 3.8
hand pain 3.8
pedal edema 3.8
leg edema 3.7
disturbed balance 3.7
orthopnea 3.7
Respiratory symptoms 3.6
body pain 3.4
pallor 3.4
non-productive cough 3.4
hypoproteinemia 3.4
oliguria 3.2
rales 3.2
thirsty 3.2
asynergy 3.2
joint stiffness 3.0
hyperacusis 3.0
Poor sleep 3.0
loss of taste 3.0
urinary frequency 2.9
erythema 2.9
constipation 2.9
intestinal bleeding 2.8
consciousness disturbance 2.8
belching 2.8
cyanosis 2.8
asthenia 2.7
Halo 2.7
numbness 2.6
hemoptysis 2.6
shortness of breath 2.6
dysesthesia 2.6
stomach pain 2.5
Depressive symptoms 2.5
syncopal episodes 2.5
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Drug
Sarpogrelate hydrochloride 8.8
Potaba 8.3
Bosentan 7.6
Bosentan 7.6
Iloprost 7.1
Treprostinil 7.1
Minipress 6.4
Olopatadine hydrochloride 6.4
Sodium metabisulfite 6.0
Panorex 6.0
Activase 5.9
NOV 5.8
Beraprost 5.7
CMX 5.7
Cisapride 5.7
Tocilizumab 5.6
Antithymocyte globulin 5.5
Beraprost sodium 5.5
Tween 85 5.4
Cilengitide 5.3
TMX 5.2
Pirfenidone 5.2
Omniscan 5.1
EML 5.1
PDGF B-chain 5.0
Muse 5.0
InCl3 5.0
Bosutinib 4.9
Abatacept 4.9
Sodium benzoate 4.9
BLyS 4.8
Sodium citrate 4.7
Sodium citrate 4.7
PFT 4.6
TFT 4.5
RbCl 4.4
RbCl 4.4
Prednisolone 4.4
PNT 4.4
Omniscan 4.4
Vanilla 4.4
Trental 4.2
CFX 4.2
ETA 4.1
Vardenafil 4.1
Silica 3.9
Imatinib 3.7
Methylprednisolone 3.7
SnF2 3.6
Rituximab 3.6
Gleevec 3.6
Prednisone 3.5
Clodronate 3.5
Antithrombin III 3.5
Zein 3.3
ZnO 3.3
Ketotifen 3.3
Dasatinib 3.3
Mirtazapine 3.2
CCL 3.2
EDR 3.2
Ergosterol 3.1
PDL 3.1
Omeprazole 3.1
Dermatol 3.1
RSM 3.1
Eculizumab 3.0
Paraffin 3.0
Infliximab 2.9
Infliximab 2.9
CIA 2.9
SBT 2.9
Cilostazol 2.8
Bumetanide 2.8
DPA 2.8
CTX 2.8
Nitric Oxide 2.7
Finasteride 2.7
Pregabalin 2.7
MEA 2.7
more...
Enzyme
EC 2.4.2.16 11.5
EC 2.4.2.26 8.1
PAH 7.5
glycuronidase 7.0
type III procollagen 6.4
arylsulfate sulfotransferase 6.1
tryptophan aminotransferase 6.1
phosphatidylserine synthase 5.5
galactosylhydroxylysyl glucosyltransferase 5.1
proteinase-3 5.1
PCE 5.1
phosphatidylglycerophosphate synthase 4.8
prolyl-tRNA synthetase 4.8
pantetheinase 4.7
Escherichia coli exonuclease III 4.6
DSR 4.6
interstitial collagenase 4.2
BAL 4.1
NMT 4.1
ACS 4.1
topoisomerase 4.0
GD3 synthase 4.0
histidyl-tRNA synthetase 3.9
topoisomerase 3.9
SCS 3.8
SPS 3.8
lysophospholipase D 3.7
PRT 3.7
PPH 3.6
glucose oxidase 3.6
PHT 3.6
lysyl hydroxylase 3.5
thiopurine methyltransferase 3.4
chondroitinase 3.3
IMP dehydrogenase 3.3
chondroitinase 3.2
Alternating 3.2
phosphodiesterase 3.2
ACE 3.2
MsrA 3.1
spermidine synthase 3.1
inositol phosphatase 3.1
acrosin 3.1
Omi/HtrA2 3.1
cholesterol oxidase 3.1
PDE 3.0
collagenase 3.0
lactate oxidase 3.0
mevalonate kinase 2.9
3'-exonuclease 2.9
GLO 2.8
choline oxidase 2.8
lysyl oxidase 2.8
TSP-1 2.8
RNA polymerase 2.7
matrix metalloproteinase 9 2.7
cholesterol esterase 2.6
aequorin 2.6
MIP 2.6
prolidase 2.5
dihydroorotate dehydrogenase 2.5
alpha-mannosidase 2.5
dihydroorotate dehydrogenase 2.5
hyaluronidase 2.5
thyroid peroxidase 2.5
5alpha-reductase 2.4
5alpha-reductase 2.4
meprin 2.4
MMP-3 2.3
matrix metalloproteinase 2 2.3
guanylate cyclase 2.3
endothelin-converting enzyme 2.2
hyaluronidase 2.1
chymase 2.1
RNase P 2.1
AMP deaminase 2.1
exoribonuclease 2.0
sialyltransferase 1.9
sialyltransferase 1.9
sialyltransferase 1.9
more...
Compound
C16H20N2O3 10.5
NMVA 10.5
dichloroacetic anhydride 9.9
CI 301 9.9
Motretinide 9.5
IQ 1 9.2
1,1,1-trifluoro-2,4-pentanedione 8.9
4-dodecylbenzenesulfonic acid 8.7
4-dodecylbenzenesulfonic acid 8.7
4-dodecylbenzenesulfonic acid 8.7
4-dodecylbenzenesulfonic acid 8.7
4-dodecylbenzenesulfonic acid 8.5
Didodecyldimethylammonium bromide 8.3
Sinomenine hydrochloride 8.2
3-thiophenecarboxylic acid 8.0
Pyromellitic dianhydride 7.8
PAH 7.5
Rubrene 7.4
MEMA 7.3
9,9-dimethyl-9,10-dihydroacridine 7.3
9,9-dimethyl-9,10-dihydroacridine 7.3
Ciprofloxacin hydrochloride 7.0
2,4,6-triphenyl-1,3,5-triazine 6.9
BVE 6.8
11-aminoundecanoic acid 6.8
CFN 6.7
HAQ 6.7
Tamibarotene 6.6
Ciprofloxacin hydrochloride 6.6
Minipress 6.4
Levcromakalim 6.3
Norethisterone acetate 6.3
Novex 6.2
Magnesium hydroxide 6.1
Tosylate 6.1
2,3-dichlorophenol 6.0
2,1,3-benzothiadiazole 6.0
Berbamine 6.0
3-amino-1-propanol 6.0
ETN 5.9
PAA 5.9
N-Hydroxysuccinimide 5.9
SHS 5.8
Hydrocodone 5.8
MoO3 5.8
ANCA 5.8
Hydroxylysine 5.7
Cisapride 5.7
PBD 5.7
1-chloronaphthalene 5.7
Olopatadine 5.7
H-69 5.6
Tamsulosin 5.6
1-propanesulfonic acid 5.5
PEI 5.5
PEI 5.5
8-iso-PGF2alpha 5.4
ANA 5.4
ANA 5.4
tetramethyl orthosilicate 5.4
tin 5.3
Vinyl chloride 5.3
ITG 5.3
Dibenzothiophene 5.3
Mycophenolate mofetil 5.3
8-MOP 5.2
indole-3-acetaldehyde 5.2
Sodium bisulfite 5.1
butyric acid 5.1
PCE 5.1
Methyl orange 5.1
CsF 5.1
GeO2 5.1
pentacene 5.0
DR-1 5.0
Ibotenic acid 5.0
Ibotenic acid 5.0
Methyl orange 5.0
butyric acid 5.0
Terazosin 5.0
more...