Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036421 (PSS)
10,989 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
PSS 2978
collagen 811
Sep 717
ACS 457
hole 282
PAH 280
cytokine 253
She 187
Mol 158
HLA 132
Poly 121
IL-6 108
topoisomerase I 107
CREST 97
CD4 93
interferon 87
ankylosing spondylitis 86
RNP 85
endothelin-1 76
rheumatoid factor 74
endothelin receptor 73
fibronectin 67
type I collagen 66
IL-4 64
IFN 62
ANA 62
ACR 60
tumor necrosis factor 60
connective tissue growth factor 60
phosphodiesterase 58
TGF-beta 58
RNA polymerase I 58
transforming growth factor-beta 57
C-reactive protein 56
chemokine 55
TNF 55
calcium channel 53
CD8 52
vascular endothelial growth factor 51
interleukin-6 51
AFM 49
autoantigen 48
smooth muscle actin 47
IgA 46
lymphoid 46
SSA 46
insulin 45
IL-10 44
Pol 44
IL-13 44
gut 42
ribonucleoprotein 41
CD19 40
IL-1 39
SMA 38
platelet-derived growth factor 38
myeloperoxidase 37
histone 37
HLA-DR 36
CD34 35
von Willebrand factor 35
serum albumin 35
fibrillin 34
hemoglobin 33
IL-17 33
major histocompatibility complex 33
polypeptide 32
tyrosine kinase 31
PDGF 31
SSB 30
U1-70K 30
interferon-gamma 30
ACE 30
IL-8 30
collagenase 30
glycoprotein 29
renin 29
NMR 29
MRI 28
vascular endothelium 28
more...
Disease
PSS 10989
PSS 2978
PSS 2978
scleroderma 2079
systemic lupus erythematosus 1500
rheumatoid arthritis 1073
Raynaud's phenomenon 780
connective tissue disease 696
autoimmune disease 653
hypertension 492
interstitial lung disease 473
dermatomyositis 445
arthritis 433
mixed connective tissue disease 371
pulmonary hypertension 352
polymyositis 320
cancer 319
lupus 313
Raynaud 308
pulmonary fibrosis 301
vasculitis 268
CREST 208
lupus 208
calcinosis 195
diffuse scleroderma 185
localized scleroderma 180
sclerodactyly 177
morphea 159
myositis 158
multiple sclerosis 153
idiopathic pulmonary fibrosis 148
vascular disease 144
SLE 134
lung disease 128
diabetes 120
telangiectasia 120
psoriasis 117
cold 116
interstitial pneumonia 116
sarcoidosis 116
renal failure 115
ischemia 114
primary biliary cirrhosis 113
dysphagia 113
Sjogren's syndrome 111
graft-versus-host disease 106
tumor 101
antiphospholipid syndrome 94
gastroesophageal reflux disease 93
atherosclerosis 93
ankylosing spondylitis 89
renal disease 83
depression 83
esophageal dysmotility 81
systemic disease 80
Pulmonary arterial hypertension 79
heart failure 77
glomerulonephritis 72
Esophageal 71
psoriatic arthritis 71
fasciitis 70
skin disease 69
rheumatism 69
osteoarthritis 63
Crohn's disease 62
gangrene 62
rare disease 62
thrombocytopenia 61
eosinophilia 60
silicosis 59
collagen disease 57
myopathy 56
Best 56
pneumonia 55
SEM 54
collagen disease 53
PAA 52
proteinuria 52
anemia 51
xerostomia 50
more...
Symptom
pain 185
dyspnea 136
arthralgia 76
weakness 68
fatigue 60
myalgia 45
diarrhea 44
erythema 35
nausea 32
cough 31
headache 30
constipation 27
heartburn 26
exertional dyspnea 25
chest pain 25
discomfort 24
collapse 24
vomiting 22
anesthesia 20
discomfort 19
abdominal pain 19
dry eye 18
thinning 17
acidity 15
seizures 13
hemoptysis 13
regurgitation 12
spasm 12
shortness of breath 11
numbness 11
bloating 11
splenomegaly 11
respiratory distress 11
pallor 9
cyanosis 9
angina 9
syncope 9
Ill 8
flushing 8
vertigo 8
livedo 7
hypothermia 6
asthenia 6
oliguria 6
paresthesia 6
Gastrointestinal symptoms 6
cachexia 6
exhaustion 5
dysarthria 5
Skin thickening 5
overweight 5
dry skin 5
back pain 5
clubbing 5
tinnitus 4
hypoproteinemia 4
insomnia 4
functional recovery 4
sleepiness 4
hepatosplenomegaly 4
Lower urinary tract symptoms 4
Depressive symptoms 4
cerebellar ataxia 4
analgesia 4
anorexia 3
urinary frequency 3
tremor 3
ataxia 3
leg edema 3
joint stiffness 3
hoarseness 3
dizziness 3
polymyalgia 3
Urinary symptoms 3
hemiplegia 3
starvation 3
polyuria 3
skin damage 3
HSA 3
dysuria 2
more...
Drug
Dermatol 758
ZnO 48
lysine 39
Cardiovasc 34
Bosentan 29
Bosentan 29
IL-2 27
Iloprost 25
IFN-gamma 24
CTX 24
TiO2 17
ETA 16
SiO2 13
ROC 13
Silica 12
Rituximab 12
caffeine 12
Imatinib 11
Prednisolone 11
vitamin E 10
Asthma 9
Gel 8
nitroglycerin 7
CSF 7
ROS 7
Tocilizumab 7
Cisapride 6
G-CSF 6
Gleevec 6
Paraffin 6
Nitric Oxide 6
ascorbate 5
CaCl2 5
Nephron 5
CaCl2 5
Dial 5
Spectrum 5
CaCl2 5
NH3 5
lactose 5
THF 5
NADH 5
Histamine 5
Prednisone 4
p75 4
Captopril 4
MAP 4
CCL 4
PFT 4
NOV 4
ABC 4
ACT 4
Treprostinil 4
Methylprednisolone 4
Nephron 4
BLM 3
Fluorescein 3
uPA 3
Acacia 3
Fluorescein 3
Infliximab 3
DPA 3
Infliximab 3
Omeprazole 3
Fraction 3
Pirfenidone 3
PTH 3
TAT 3
Retinoic acid 2
RbCl 2
Dasatinib 2
Antithymocyte globulin 2
RbCl 2
EML 2
Angiotensin II 2
PDGF B-chain 2
Gastro 2
PDL 2
CMX 2
Abatacept 2
more...
Enzyme
ACS 457
PAH 280
RNA polymerase 80
peroxidase 65
phosphodiesterase 59
ACE 57
topoisomerase 52
topoisomerase 50
collagenase 49
ERK 35
focal adhesion kinase 33
mitogen-activated protein kinase 33
renin 29
thrombin 23
lysozyme 22
superoxide dismutase 22
glucose oxidase 22
type III procollagen 20
creatine kinase 20
alkaline phosphatase 20
trypsin 18
reverse transcriptase 16
PCE 15
RNase 14
guanylate cyclase 14
catalase 13
RNase 12
BAL 12
urokinase-type plasminogen activator 12
hyaluronidase 12
protein kinase C 12
tissue plasminogen activator 11
PDE 10
plasmin 10
MIP 10
beta-galactosidase 10
protein kinase 9
NO synthase 9
lactate dehydrogenase 9
proteasome 9
elastase 8
chondroitinase 7
chondroitinase 7
luciferase 7
hyaluronidase 7
ribonuclease 7
ribonuclease 7
prostate-specific antigen 7
MMP-3 6
caspase-3 6
NADPH oxidase 6
pepsin 6
interstitial collagenase 6
acetylcholinesterase 6
acid phosphatase 6
thromboplastin 6
NADPH oxidase 6
thyroid peroxidase 6
SCS 5
lipase 5
urease 5
phospholipase C 5
pyruvate dehydrogenase 5
lipoxygenase 5
DNase 5
matrix metalloproteinase 9 5
urease 5
glutathione S-transferase 5
Alternating 5
calcineurin 5
transcriptase 5
MMP 4
matrix metalloproteinase 2 4
beta-glucuronidase 4
ceruloplasmin 4
caspase-1 4
proteinase-3 4
MEK 4
APC 4
laccase 4
more...
Compound
Clin 1296
Dec 789
sodium 515
ACS 457
ACS 457
water 388
DNA 306
PAH 280
salt 199
calcium 187
oxygen 179
tin 161
CO2 144
silicon 117
silver 103
prostacyclin 88
sulfate 77
nitric oxide 73
hydrogen 72
PEG 72
acetate 70
butyric acid 68
butyric acid 68
butyric acid 68
phosphate 66
PEI 65
PEI 65
ammonium 63
glucose 62
ANA 62
ANA 62
Cardiol 60
PEG 59
vinyl 56
TNF 55
creatinine 55
copper 54
PAA 52
bromide 50
acrylic acid 45
tyrosine 43
zinc 42
thiophene 41
ethanol 41
lysine 41
iron 39
DMSO 39
nitrogen 38
Collagen 38
iodine 37
aluminum 36
potassium 36
arginine 36
ANCA 35
proline 33
barium 33
vitamin D 31
methanol 31
tryptophan 30
tryptophan 30
tryptophan 29
His 29
tryptophan 29
titanium 25
CTX 24
SiO2 24
TEM 23
serine 23
nickel 22
fluorine 22
hyaluronic acid 21
isopropanol 20
benzene 20
nitrate 19
phosphorus 19
Nifedipine 18
NH2 17
carbonate 17
prostaglandin E1 17
molybdenum 17
more...