Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036421 (PSS)
 10,989 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
PSS 2978
collagen 811
Sep 717
ACS 457
hole 282
PAH 280
cytokine 253
She 187
Mol 158
HLA 132
Poly 121
IL-6 108
topoisomerase I 107
CREST 97
CD4 93
interferon 87
ankylosing spondylitis 86
RNP 85
endothelin-1 76
rheumatoid factor 74
endothelin receptor 73
fibronectin 67
type I collagen 66
IL-4 64
ANA 62
IFN 62
connective tissue growth factor 60
tumor necrosis factor 60
ACR 60
RNA polymerase I 58
phosphodiesterase 58
TGF-beta 58
transforming growth factor-beta 57
C-reactive protein 56
TNF 55
chemokine 55
calcium channel 53
CD8 52
vascular endothelial growth factor 51
interleukin-6 51
AFM 49
autoantigen 48
smooth muscle actin 47
SSA 46
lymphoid 46
IgA 46
insulin 45
IL-13 44
Pol 44
IL-10 44
gut 42
ribonucleoprotein 41
CD19 40
IL-1 39
SMA 38
platelet-derived growth factor 38
myeloperoxidase 37
histone 37
HLA-DR 36
von Willebrand factor 35
serum albumin 35
CD34 35
fibrillin 34
major histocompatibility complex 33
IL-17 33
hemoglobin 33
polypeptide 32
PDGF 31
tyrosine kinase 31
U1-70K 30
collagenase 30
ACE 30
IL-8 30
interferon-gamma 30
SSB 30
renin 29
glycoprotein 29
NMR 29
SS-A 28
MRI 28
vascular endothelium 28
IL-2 27
DNA topoisomerase I 27
FIB 27
Mal 26
IFN-gamma 26
ET-1 26
PM-Scl 26
DR5 25
Cytokine 25
natriuretic peptide 25
albumin 25
fibrinogen 24
CD20 24
thymus 24
ESR 24
interleukin-2 23
CRP 23
thrombin 23
Endothelin-1 23
ENA 23
CTGF 22
peroxidase 22
human leukocyte antigen 22
lysozyme 22
MCP-1 22
CBT 21
CCL2 21
interleukin-4 21
nitric oxide synthase 21
FLI 21
Smad3 20
ICAM-1 20
proton pump 20
Smad2 19
ARA 19
TLR4 19
PEG 19
CENP-B 19
alkaline phosphatase 19
CD25 19
TEM 19
superoxide dismutase 19
HLA class II 19
CIE 19
kit 18
ETA 18
MHC 18
DR3 18
PVA 17
vascular cell adhesion molecule-1 17
VEGF 17
dilute 17
T cell receptor 17
E-selectin 16
COL1A2 16
SS-B 16
ATP 16
MMP-1 16
type I procollagen 16
COL1A1 16
TNF-alpha 16
Fas 15
angiotensin II 15
ETB 15
PBS 15
proteoglycan 15
type I interferon 15
creatine kinase 15
CD28 15
IL-1 beta 15
IgE 15
intercellular adhesion molecule-1 15
adhesion molecule 15
CD45 14
c-kit 14
alpha-smooth muscle actin 14
ERK 14
chronic renal failure 14
CD31 14
more...
Disease
PSS 10989
PSS 2978
PSS 2978
scleroderma 2079
systemic lupus erythematosus 1500
rheumatoid arthritis 1073
Raynaud's phenomenon 780
connective tissue disease 696
autoimmune disease 653
hypertension 492
interstitial lung disease 473
dermatomyositis 445
arthritis 433
mixed connective tissue disease 371
pulmonary hypertension 352
polymyositis 320
cancer 319
lupus 313
Raynaud 308
pulmonary fibrosis 301
vasculitis 268
lupus 208
CREST 208
calcinosis 195
diffuse scleroderma 185
localized scleroderma 180
sclerodactyly 177
morphea 159
myositis 158
multiple sclerosis 153
idiopathic pulmonary fibrosis 148
vascular disease 144
SLE 134
lung disease 128
telangiectasia 120
diabetes 120
psoriasis 117
cold 116
interstitial pneumonia 116
sarcoidosis 116
renal failure 115
ischemia 114
dysphagia 113
primary biliary cirrhosis 113
Sjogren's syndrome 111
graft-versus-host disease 106
tumor 101
antiphospholipid syndrome 94
atherosclerosis 93
gastroesophageal reflux disease 93
ankylosing spondylitis 89
renal disease 83
depression 83
esophageal dysmotility 81
systemic disease 80
Pulmonary arterial hypertension 79
heart failure 77
glomerulonephritis 72
psoriatic arthritis 71
Esophageal 71
fasciitis 70
skin disease 69
rheumatism 69
osteoarthritis 63
gangrene 62
rare disease 62
Crohn's disease 62
thrombocytopenia 61
eosinophilia 60
silicosis 59
collagen disease 57
Best 56
myopathy 56
pneumonia 55
SEM 54
collagen disease 53
proteinuria 52
PAA 52
anemia 51
xerostomia 50
carcinoma 50
lymphoma 49
heart disease 48
malabsorption 48
chronic disease 46
breast cancer 46
cardiomyopathy 46
type 1 diabetes 46
atopic dermatitis 44
neuropathy 44
Lupus 44
asthma 43
Wegener's granulomatosis 43
acute renal failure 41
cardiovascular disease 41
polyarteritis nodosa 41
esophagitis 40
Scleroderma renal crisis 40
Graves' disease 39
lung cancer 39
pericarditis 39
respiratory failure 38
skin ulcers 38
hemolytic anemia 37
polyarthritis 37
cirrhosis 36
Dermal 35
hypothyroidism 34
osteoporosis 34
Hashimoto's thyroiditis 34
infectious diseases 33
HIV 33
malignant hypertension 33
pemphigus 32
pericardial effusion 32
myasthenia gravis 31
myocardial infarction 30
myocarditis 30
inflammatory bowel disease 30
hepatitis 30
ulcerative colitis 30
amyloidosis 30
right heart failure 29
malnutrition 29
congestive heart failure 29
lupus nephritis 28
purpura 28
Epstein 28
pruritus 27
adenocarcinoma 27
renal insufficiency 27
Syndrome 26
liver disease 26
Eosinophilic fasciitis 26
cryoglobulinemia 26
juvenile rheumatoid arthritis 26
stroke 26
plaque 25
primary pulmonary hypertension 25
autoimmune thyroiditis 25
multiple myeloma 25
cutaneous T-cell lymphoma 25
hypergammaglobulinemia 24
lymphadenopathy 24
uveitis 24
melanoma 24
vitiligo 24
coronary artery disease 24
nephritis 24
scleromyxedema 23
cytomegalovirus 23
Behcet's disease 23
tuberculosis 23
peripheral neuropathy 23
dermatitis 23
chronic obstructive pulmonary disease 22
scleredema 22
giant cell arteritis 22
fibromyalgia 22
posttraumatic stress disorder 22
more...
Symptom
pain 185
dyspnea 136
arthralgia 76
weakness 68
fatigue 60
myalgia 45
diarrhea 44
erythema 35
nausea 32
cough 31
headache 30
constipation 27
heartburn 26
chest pain 25
exertional dyspnea 25
collapse 24
discomfort 24
vomiting 22
anesthesia 20
discomfort 19
abdominal pain 19
dry eye 18
thinning 17
acidity 15
hemoptysis 13
seizures 13
spasm 12
regurgitation 12
respiratory distress 11
splenomegaly 11
shortness of breath 11
bloating 11
numbness 11
angina 9
syncope 9
cyanosis 9
pallor 9
Ill 8
flushing 8
vertigo 8
livedo 7
hypothermia 6
oliguria 6
cachexia 6
asthenia 6
paresthesia 6
Gastrointestinal symptoms 6
dysarthria 5
back pain 5
exhaustion 5
Skin thickening 5
clubbing 5
dry skin 5
overweight 5
sleepiness 4
hypoproteinemia 4
tinnitus 4
analgesia 4
cerebellar ataxia 4
insomnia 4
Lower urinary tract symptoms 4
functional recovery 4
Depressive symptoms 4
hepatosplenomegaly 4
leg edema 3
ataxia 3
anorexia 3
hemiplegia 3
tremor 3
skin damage 3
Urinary symptoms 3
joint stiffness 3
polymyalgia 3
starvation 3
polyuria 3
dizziness 3
HSA 3
hoarseness 3
urinary frequency 3
sciatica 2
blurred vision 2
facial pain 2
fever of unknown origin 2
tingling 2
Hudson 2
dysesthesia 2
Signs and Symptoms 2
stigma 2
fasciculation 2
abdominal fullness 2
asynergy 2
Respiratory symptoms 2
paresis 2
cardiovascular impairment 2
rales 2
muscle rigidity 2
polydipsia 2
orthopnea 2
prostatism 2
pelvic pain 2
generalized pain 2
hepatomegaly 2
epigastric pain 2
skin irritation 2
consciousness disturbance 2
stridor 2
hip pain 2
intestinal bleeding 2
acute abdominal pain 2
hypercapnia 2
dysuria 2
Overlying 1
emaciation 1
bradykinesia 1
belching 1
tachypnea 1
facial droop 1
Red face 1
Skin symptoms 1
ischuria 1
hyperacusis 1
memory loss 1
menometrorrhagia 1
Halo 1
bitter taste 1
generalized abdominal pain 1
Wind 1
astasia 1
Musculoskeletal symptoms 1
distraction 1
S3 gallop 1
POA 1
peau d'orange 1
incoordination 1
wheezing 1
Neurologic symptoms 1
painful swallowing 1
disturbed balance 1
scaly skin 1
neck pain 1
skin pain 1
persistent cough 1
paraparesis 1
pedal edema 1
adenitis 1
pleuritic chest pain 1
agitation 1
apathy 1
Welt 1
photophobia 1
productive cough 1
acid regurgitation 1
reproductive problem 1
loss of taste 1
stomach pain 1
tonic-clonic seizure 1
alexithymia 1
physical appearance 1
nausea and vomiting 1
hand pain 1
more...
Drug
Dermatol 758
ZnO 48
lysine 39
Cardiovasc 34
Bosentan 29
Bosentan 29
IL-2 27
Iloprost 25
IFN-gamma 24
CTX 24
TiO2 17
ETA 16
ROC 13
SiO2 13
Silica 12
Rituximab 12
caffeine 12
Prednisolone 11
Imatinib 11
vitamin E 10
Asthma 9
Gel 8
Tocilizumab 7
CSF 7
nitroglycerin 7
ROS 7
G-CSF 6
Gleevec 6
Paraffin 6
Nitric Oxide 6
Cisapride 6
NH3 5
THF 5
NADH 5
CaCl2 5
Nephron 5
Histamine 5
ascorbate 5
Dial 5
CaCl2 5
Spectrum 5
lactose 5
CaCl2 5
ACT 4
PFT 4
NOV 4
CCL 4
Methylprednisolone 4
Captopril 4
ABC 4
MAP 4
Treprostinil 4
p75 4
Prednisone 4
Nephron 4
Omeprazole 3
Fluorescein 3
Infliximab 3
DPA 3
uPA 3
Fluorescein 3
Acacia 3
BLM 3
Infliximab 3
TAT 3
PTH 3
Fraction 3
Pirfenidone 3
Retinoic acid 2
DNase I 2
Antithrombin III 2
BLyS 2
TFT 2
PDL 2
EML 2
Antithymocyte globulin 2
CTA 2
RbCl 2
Dasatinib 2
Simvastatin 2
CTC 2
CAM 2
Angiotensin II 2
ampicillin 2
Gastro 2
PCP 2
RbCl 2
Abatacept 2
CIA 2
Monit 2
Sarpogrelate hydrochloride 2
Portal 2
CMX 2
Asn 2
ENT 2
Dakar 2
CTC 2
CDP 2
Aloe 2
Activin 2
Award 2
Fragment 2
PDGF B-chain 2
Allergen 1
balanced salt solution 1
TMX 1
Riboflavin 1
Glycyrrhiza 1
Sodium benzoate 1
MOF 1
SnF2 1
Spectrum 1
SBT 1
Android 1
Bumetanide 1
Cilostazol 1
Hyaluronidase 1
DFP 1
PNT 1
Forskolin 1
Eculizumab 1
PTC 1
Fructose 1
Adenosine triphosphate 1
EDR 1
Viagra 1
FAD 1
-deoxyadenosine 1
Gelatin 1
Papaverine 1
Muse 1
Arsenic trioxide 1
Finasteride 1
Minipress 1
Omniscan 1
Methylene blue 1
Bosutinib 1
IL-11 1
Sodium citrate 1
Clodronate 1
Glutathione 1
Alliance 1
Cimetidine 1
niacin 1
ADM 1
Citric acid 1
DMI 1
Denosumab 1
citric acid 1
IPM 1
MRC 1
Indomethacin 1
Ketotifen 1
CFX 1
Ethanol 1
TAC 1
Omniscan 1
Campath 1
CTX 1
GEO 1
more...
Enzyme
ACS 457
PAH 280
RNA polymerase 80
peroxidase 65
phosphodiesterase 59
ACE 57
topoisomerase 52
topoisomerase 50
collagenase 49
ERK 35
focal adhesion kinase 33
mitogen-activated protein kinase 33
renin 29
thrombin 23
glucose oxidase 22
lysozyme 22
superoxide dismutase 22
alkaline phosphatase 20
type III procollagen 20
creatine kinase 20
trypsin 18
reverse transcriptase 16
PCE 15
guanylate cyclase 14
RNase 14
catalase 13
urokinase-type plasminogen activator 12
hyaluronidase 12
RNase 12
protein kinase C 12
BAL 12
tissue plasminogen activator 11
MIP 10
plasmin 10
beta-galactosidase 10
PDE 10
proteasome 9
protein kinase 9
NO synthase 9
lactate dehydrogenase 9
elastase 8
ribonuclease 7
hyaluronidase 7
luciferase 7
ribonuclease 7
prostate-specific antigen 7
chondroitinase 7
chondroitinase 7
interstitial collagenase 6
NADPH oxidase 6
caspase-3 6
MMP-3 6
thromboplastin 6
NADPH oxidase 6
pepsin 6
acid phosphatase 6
acetylcholinesterase 6
thyroid peroxidase 6
SCS 5
lipoxygenase 5
transcriptase 5
phospholipase C 5
glutathione S-transferase 5
lipase 5
urease 5
Alternating 5
calcineurin 5
urease 5
pyruvate dehydrogenase 5
matrix metalloproteinase 9 5
DNase 5
caspase-1 4
matrix metalloproteinase 2 4
monoamine oxidase 4
ATPase 4
MMP 4
ceruloplasmin 4
APC 4
MEK 4
proteinase-3 4
beta-glucuronidase 4
laccase 4
SPS 4
kallikrein 3
PARP 3
IMP dehydrogenase 3
IKK 3
lysyl oxidase 3
phospholipase A2 3
chymotrypsin 3
gamma-glutamyl transpeptidase 3
transglutaminase 3
aequorin 3
tryptase 3
hexosaminidase 3
alanine aminotransferase 3
pyruvate dehydrogenase 3
pyruvate dehydrogenase 3
alpha-mannosidase 3
TAT 3
phosphatidylserine synthase 3
sialyltransferase 2
EC 2.4.2.26 2
RNase P 2
aldolase 2
cholesterol oxidase 2
MAP 2
sialyltransferase 2
CD13 2
hexokinase 2
chymase 2
sialyltransferase 2
phosphoinositide 3-kinase 2
dipeptidyl peptidase IV 2
xanthine oxidase 2
NOS 2
acrosin 2
cholesterol esterase 2
beta-glucosidase 2
CD10 2
arylsulfate sulfotransferase 2
prolyl hydroxylase 2
furin 2
P-glycoprotein 2
TSP-1 2
histone acetyltransferase 2
micrococcal nuclease 2
5alpha-reductase 2
beta-glucosidase 2
neuraminidase 2
adenylate cyclase 2
PCP 2
ATP synthase 2
CPT 2
thiopurine methyltransferase 2
adenosine deaminase 2
chitinase 2
caspase-8 2
BMT 2
5alpha-reductase 2
PRT 1
arylsulfatase 1
deoxyribonuclease 1
adenosine deaminase 1
CAD 1
MDR 1
CAD 1
mevalonate kinase 1
prolyl-tRNA synthetase 1
AMP deaminase 1
PHT 1
cathepsin L 1
tissue kallikrein 1
PPH 1
pyruvate kinase 1
histidyl-tRNA synthetase 1
glutamate dehydrogenase 1
hypoxanthine-guanine phosphoribosyltransferase 1
tryptophan 2,3-dioxygenase 1
PKG 1
more...
Compound
Clin 1296
Dec 789
sodium 515
ACS 457
ACS 457
water 388
DNA 306
PAH 280
salt 199
calcium 187
oxygen 179
tin 161
CO2 144
silicon 117
silver 103
prostacyclin 88
sulfate 77
nitric oxide 73
PEG 72
hydrogen 72
acetate 70
butyric acid 68
butyric acid 68
butyric acid 68
phosphate 66
PEI 65
PEI 65
ammonium 63
ANA 62
glucose 62
ANA 62
Cardiol 60
PEG 59
vinyl 56
TNF 55
creatinine 55
copper 54
PAA 52
bromide 50
acrylic acid 45
tyrosine 43
zinc 42
ethanol 41
lysine 41
thiophene 41
DMSO 39
iron 39
Collagen 38
nitrogen 38
iodine 37
arginine 36
aluminum 36
potassium 36
ANCA 35
barium 33
proline 33
methanol 31
vitamin D 31
tryptophan 30
tryptophan 30
tryptophan 29
tryptophan 29
His 29
titanium 25
SiO2 24
CTX 24
TEM 23
serine 23
nickel 22
fluorine 22
hyaluronic acid 21
benzene 20
isopropanol 20
phosphorus 19
nitrate 19
Nifedipine 18
NH2 17
carbonate 17
prostaglandin E1 17
molybdenum 17
hydroxide 16
ETA 16
ATP 16
BLM 16
PVA 16
PCE 15
DPA 15
PCE 15
galactose 15
DPA 15
DPA 15
mercury 15
glutamic acid 15
SDS 15
DPA 15
PVP 15
DPA 15
ASA 14
methionine 14
acetone 14
leucine 14
HAQ 14
Triton X-100 14
Optimal 14
DTPA 14
noradrenaline 14
cysteine 13
5-HT 13
BAL 13
chloroform 13
urea 13
sulfuric acid 13
pyridine 13
pentacene 13
N-acetylcysteine 12
sodium chloride 12
HCl 12
ADP 12
DMF 12
ammonia 12
caffeine 12
alanine 12
glycerol 12
MDA 11
Methotrexate 11
cGMP 11
toluene 11
acetic acid 11
Asp 11
ClO 10
cadmium 10
2-ethylhexyl 10
ADP 10
Prednisolone 10
Vitamin D 10
H2O2 10
BNP 10
ADP 10
EDTA 10
PMA 10
glutamate 10
2-ethylhexyl 10
CTAB 10
pyrene 10
2-ethylhexyl 10
EDTA 10
PAP 9
PMA 9
ATA 9
TSH 9
aniline 9
Angiotensin II 9
chlorine 9
selenium 9
Sildenafil 9
vanadium 8
cobalt 8
xylose 8
tungsten 8
MoO3 8
more...