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Query: UMLS:C0036341 (
schizophrenia
)
60,220
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Schizophrenia
is a severe neuropsychiatric disorder with core features including hallucinations, delusions, and cognition deficits. Accumulating evidence has implicated abnormal DNA methylation in the development of
schizophrenia
. However, the mechanisms by which DNA methylation changes alter the risk for
schizophrenia
remain largely unknown. We recently carried out a DNA methylome study of peripheral blood samples from 469 first-episode patients with
schizophrenia
and 476 age- and gender-matched healthy controls of Han Chinese origin. Genomic DNA methylation patterns were quantified using an Illumina Infinium Human MethylationEPIC BeadChip. We identified multiple differentially methylated positions (DMPs) and regions between patients and controls. The most significant DMPs were annotated to genes
C17orf53
, THAP1 and KCNQ4 (K
V
7.4), with Bonferroni-adjusted P values of [Formula: see text], [Formula: see text], and [Formula: see text], respectively. In particular, KCNQ4 encodes a voltage-gated potassium channel of the K
V
7 family, which is linked to neuronal excitability. The genes associated with top-ranked DMPs also included many genes involved in nervous system development, such as LIMK2 and TMOD2. Gene ontology analysis of the differentially methylated genes further identified strong enrichment of neuronal networks, including neuron projection extension, axonogenesis and neuron apoptotic process. Finally, we provided evidence that
schizophrenia
-associated epigenetic alterations co-localize with genetic susceptibility loci. By focusing on first-episode
schizophrenia
patients, our investigation lends particularly strong support for an important role of DNA methylation in
schizophrenia
pathogenesis unconfounded by the effects of long-term antipsychotic medication or disease progression. The observed DNA methylation aberrations in
schizophrenia
patients could potentially provide a valuable resource for identifying diagnostic biomarkers and developing novel therapeutic targets to benefit
schizophrenia
patients.
...
PMID:Genome-wide DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia in the Chinese Han population. 3327 32
