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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study examined the extent to which positive and negative schizotypy are associated with impairment in recognition memory in 3 large samples of nonclinically ascertained adults (total n = 826). Schizophrenia is associated with a wide array of cognitive deficits, but the study of cognitive impairment in schizophrenia is confounded by generalized performance deficits related to symptoms and consequences of the disorder, and by failure to separately examine positive and negative symptom dimensions. Schizotypy provides a promising framework for examining these deficits relatively unconfounded by symptoms and sequelae of the disorder. The present study obtained recognition memory deficits in positive and negative schizotypy across verbal and figural stimuli in three different samples. Importantly, although discrimination accuracy is impaired across higher scores on both schizotypy dimensions, the mechanism of impairment differs across positive and negative schizotypy. Negative, but not positive, schizotypy was associated with impaired hit rates, whereas the false alarm rates remained unaffected. In contrast, positive, but not negative, schizotypy was associated with increased false alarm rates despite stable hit rates. The results are discussed from the perspective of a signal-detection theoretic model that accounts for negative schizotypy results through reduced signal mechanism, and accounts for positive schizotypy results through increased noise mechanism. These findings further support the utility of multidimensional schizotypy for assessing and understanding episodic memory impairment in the schizophrenia spectrum. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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PMID:Hits and false alarms in recognition memory show differential impairment in positive and negative schizotypy. 3131 42

The stress-vulnerability-protective factors model is often used to explain the etiology and known risk and protective factors of initial psychotic symptoms and symptomatic relapses. Over the past 40 years since its initial conception, the model has evolved and gathered a plethora of evidence of varying quality for its different components. The objective of this metareview is to analyze the quality of the evidence and the effect sizes for each component of the model not previously reviewed. Recent meta-analyses covering each component of the model in relation to the onset of psychotic symptoms or symptomatic relapse in schizophrenia were reviewed with the grading of recommendations, assessment, development, and evaluation system. Thirty-one meta-analyses were kept, from 3,044 papers reviewed. We did not add to previous metareviews in terms of obstetric/prenatal or genetic vulnerabilities. For stressors, moderate to strong research evidence was found for childhood adversity, cannabis, methamphetamine abuse, and expressed emotions as triggers of psychotic relapse or as linked to the onset of psychotic symptoms. For protective factors, moderate to strong evidence was found for antipsychotic medication in adults, family interventions, social skills training, as well as interventions focusing on recovery management skills. Poor evidence or no evidence (i.e., absence of meta-analyses) were found for the other components of the model. More rigorous studies and systematic reviews are needed in order to validate the various components of the model in regard to symptom onset and relapse. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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PMID:Predicting and preventing symptom onset and relapse in schizophrenia-A metareview of current empirical evidence. 3134 81

Posttraumatic stress disorder (PTSD) in young individuals is associated with an increased risk to develop psychosis or mania, and both trauma and PTSD rates are elevated in people with schizophrenia and other severe mental illnesses. However, less research has examined PTSD in people who have recently developed a first episode of psychosis (FEP). The present study is a secondary analysis of the baseline data collected for the National Institute of Mental Health Recovery After an Initial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) study to examine the rates of trauma and PTSD, and to explore the demographic and clinical correlates of PTSD in a representative sample of 404 persons with an FEP. Approximately 80% of the study sample reported experiencing at least one traumatic event during their lives, with females more likely to report childhood sexual abuse and spousal abuse than males. A total of 20 participants (5.0%) met criteria for a lifetime diagnosis of PTSD, while another 15 participants (3.7%) met subthreshold diagnostic criteria for PTSD. Significant correlations were found between lifetime PTSD and the Calgary Depression Scale, the Mental Health Recovery Measure, the Stigma Scale, and duration of untreated psychosis, with higher scores on each variable associated with a diagnosis of PTSD. The association between PTSD and more severe depression, as well as lower perceptions of personal recovery, suggest that PTSD may be an important target for treatment programs for persons recovering from an FEP. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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PMID:Prevalence and correlates of PTSD in first episode psychosis: Findings from the RAISE-ETP study. 3134 88

Negative symptoms are a core clinical feature of schizophrenia that are only marginally responsive to current treatments. Recent work suggests that deficits in reinforcement learning and anticipatory responses to reward may be two mechanisms that help explain impairments in motivation in those with schizophrenia. The present study utilized a reinforcement-learning paradigm, which allowed us to examine both reward anticipation and reinforcement learning. Twenty-eight people with schizophrenia and 30 healthy controls completed a reinforcement-learning task while undergoing functional MRI. Participants with schizophrenia also completed a weeklong ecological momentary assessment protocol reporting anticipated motivation and pleasure in their daily activities. Unexpectedly, we found no significant group differences in performance or neural response in reinforcement learning. However, we found that poorer reward learning was associated with greater clinician ratings of negative symptoms and daily reports of anticipatory motivation and pleasure negative symptoms. In regards to anticipatory responses, we found that people with schizophrenia showed blunted activation in the anterior cingulate, insula, caudate, and putamen while anticipating reward. Further, blood oxygen level-dependent (BOLD) response in reward related regions during anticipation of reward was significantly related to both clinician-rated motivation and pleasure deficits as well as daily reports of motivation and pleasure. Our results provide further evidence of deficits during reward anticipation in individuals with schizophrenia, particularly for those with severe negative symptoms, and some evidence for worse reward learning among those with greater negative symptoms. Moreover, our findings suggest that these deficits show important relationships with emotional and motivational functioning in everyday life. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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PMID:From neuroimaging to daily functioning: A multimethod analysis of reward anticipation in people with schizophrenia. 3146 49

Individuals with schizophrenia exhibit deficits in facial emotion processing, which have been associated with abnormalities in visual gaze behavior and functional brain activation. However, the relationship between gaze behavior and brain activation in schizophrenia remains unexamined. Studies in healthy individuals and other clinical samples indicate a relationship between gaze behavior and functional activation in brain regions implicated in facial emotion processing deficits in schizophrenia (e.g., fusiform gyrus), prompting the question of whether a similar relationship exists in schizophrenia. This study examined whether manipulating visual scanpaths during facial emotion perception would modulate functional brain activation in a sample of 23 schizophrenia patients and 26 community controls. Participants underwent functional magnetic resonance imaging (MRI) while viewing pictures of emotional faces. During the typical viewing condition, a fixation cue directed participants' gaze primarily to the eyes and mouth, whereas during the atypical viewing condition gaze was directed to peripheral features. Both viewing conditions elicited a robust response throughout face-processing regions. Typical viewing led to greater activation in visual association cortex including the right inferior occipital gyrus/occipital face area, whereas atypical viewing elicited greater activation in primary visual cortex and regions involved in attentional control. There were no between-groups activation differences in response to faces or interaction between group and gaze manipulation. The results indicate that gaze behavior modulates functional activation in early face-processing regions in individuals with and without schizophrenia, suggesting that abnormal gaze behavior in schizophrenia may contribute to activation abnormalities during facial emotion perception. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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PMID:Manipulating visual scanpaths during facial emotion perception modulates functional brain activation in schizophrenia patients and controls. 3153 86

Psychopathy is a personality disorder that is often stigmatized in both the general population and in legal settings. Although individuals with psychopathy face significant stigma, individuals with elevated psychopathic traits may hold fewer stigmatizing beliefs about this population. It is unclear, however, if this relationship stems from feelings of similarity or from traits of fearlessness that are commonly observed in some psychopathic individuals. In this study, 661 participants from the community were recruited online and completed the Triarchic Psychopathy Measure. They were then randomly assigned to read a description of either a nonviolent or violent psychopath, as well as either a nonviolent or violent person with schizophrenia. All participants also read a vignette of a nondangerous person with depression. For each description, participants completed the Attribution Questionnaire to measure stigmatizing attributes based on the vignette. Psychopathic traits were negatively associated with the stigmatization of individuals presented as either dangerous or nondangerous psychopaths, but were not associated with either forms of schizophrenia or with depression. Findings are explained in terms of identification with psychopaths. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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PMID:Affinity between us: Examining how psychopathic traits influence the stigmatization of psychiatric disorders. 3154 36

This article memorializes Kurt Salzinger (1929-2018). Salzinger's main focus of research was schizophrenic speech and its functional characteristics. Collaborating with several colleagues, most notably Stephanie Portnoy (nee Pisoni) and Richard S. Feldman, he documented verbal conditioning without awareness through ingenious experiments in the clinic waiting room, finding that patients with schizophrenia differed from normal controls only in their rates of extinction. They then found that self-referencing statements not only were susceptible to subtle reinforcers, but also that speed of such conditioning predicted the duration of hospitalization. Addressing more generally, they found evidence for an "immediacy hypothesis," whereby individuals with schizophrenia reacted to an extremely limited range of immediate events, including their own utterances. Among the acknowledgments of the quality of his research were an NSF Award for Sustained Superior Performance in 1981 and "The Most Meritorious Article in 1994" award by the Journal of Behavior Therapy and Experimental Psychiatry. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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PMID:Kurt Salzinger (1929-2018). 3154 45

Obsessive and Compulsive Symptoms (OCS) or Obsessive Compulsive Disorder (OCD) in the context of schizophrenia or related disorders are of clinical importance as these are associated with a range of adverse outcomes. Natural Language Processing (NLP) applied to Electronic Health Records (EHRs) presents an opportunity to create large datasets to facilitate research in this area. This is a challenging endeavour however, because of the wide range of ways in which these symptoms are recorded, and the overlap of terms used to describe OCS with those used to describe other conditions. We developed an NLP algorithm to extract OCS information from a large mental healthcare EHR data resource at the South London and Maudsley NHS Foundation Trust using its Clinical Record Interactive Search (CRIS) facility. We extracted documents from individuals who had received a diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder. These text documents, annotated by human coders, were used for developing and refining the NLP algorithm (600 documents) with an additional set reserved for final validation (300 documents). The developed NLP algorithm utilized a rules-based approach to identify each of symptoms associated with OCS, and then combined them to determine the overall number of instances of OCS. After its implementation, the algorithm was shown to identify OCS with a precision and recall (with 95% confidence intervals) of 0.77 (0.65-0.86) and 0.67 (0.55-0.77) respectively. The development of this application demonstrated the potential to extract complex symptomatic data from mental healthcare EHRs using NLP to facilitate further analyses of these clinical symptoms and their relevance for prognosis and intervention response.
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PMID:Use of Natural Language Processing to identify Obsessive Compulsive Symptoms in patients with schizophrenia, schizoaffective disorder or bipolar disorder. 3157 48

Disturbances in motivation are prominent in the clinical presentation of people with schizophrenia and might reflect a disturbance in reward processing. Recent advances in affective neuroscience have subdivided reward processing into distinct components, but there are two limitations of the prior work in schizophrenia. First, studies typically focus on only one component rather than on the unfolding of reward processing across multiple stages. Second, studies have not considered the impact of certainty effects, which represent an important contextual factor that impacts processing. We examined whether individuals with schizophrenia show the typical certainty effects across three phases of reward processing: cue evaluation, feedback anticipation, and feedback receipt. Electroencephalography from 74 healthy controls and 92 people with schizophrenia was recorded during a cued gambling task under conditions in which cues indicated forthcoming reward outcomes that were certain or uncertain. Controls demonstrated the expected certainty effects across each stage. Initial cue evaluation (cue P300) was intact in the schizophrenia group, but people with schizophrenia showed diminished certainty effects during feedback anticipation (stimulus-preceding negativity [SPN]) and receipt (feedback reward positivity [fRewP] and feedback P300). During feedback receipt, event-related potentials in people with schizophrenia were similar to controls for the uncertain context but larger than controls for the certain context. Essentially, people with schizophrenia appeared to process certain feedback as though it were uncertain. These findings show, for the first time, that the fundamental distinction between certain and uncertain contexts is altered in schizophrenia at a neural level. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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PMID:Reward processing in certain versus uncertain contexts in schizophrenia: An event-related potential (ERP) study. 3165 97

Etiological models highlight the importance of emotions for the emergence of persecutory ideation. To increase our understanding of their exacerbation, we tested whether this process can be explained by a vicious cycle of negative emotions and persecutory ideation in daily life. Furthermore, we examined whether this process differs in people with and without a psychotic disorder by testing a sample of 34 individuals with elevated psychotic experiences without a diagnosis (subclinical sample) and a sample of 33 individuals diagnosed with schizophrenia spectrum disorder (clinical sample). In both samples, we applied the experience sampling method for 1 week to acquire repeated measures of sadness, fear, anger, shame, and persecutory ideation. Multilevel models showed that all tested negative emotions were associated with persecutory ideation measured at the same time point (p < .05) in both samples. Fear predicted subsequent persecutory ideation (p < .05). There was a moderating effect between sample and anger and sample and sadness predicting subsequent persecutory ideation (p < .05), with these associations being stronger in the subclinical sample. Finally, persecutory ideation predicted subsequent fear, anger, sadness, and shame (p < .05) without a moderating effect of the sample. Hence, the results showed an emotion-unspecific rather than an emotion-specific vicious cycle of negative emotions and persecutory ideation, which possibly contributes to symptom exacerbation and maintenance. Potential differences in mechanisms relating to emotions and persecutory ideation before and after the manifestation of the disorder are discussed. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
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PMID:Emotions and persecutory ideation in daily life: On the trail of the "chicken and egg" problem. 3182 37


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