Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0036341 (
schizophrenia
)
60,220
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Sustained attention as measured by the Continuous Performance Test (CPT) has proved a valuable endophenotype for
schizophrenia
. Recently pharmacological studies suggested a role of the serotonin (5-HT) 3 receptor in
schizophrenia
. The 5-HT3 receptors are the only ligand-gated ion channels within the 5-HT receptor family. Applying an endophenotype approach, we investigated a potential impact of the genes of the 5-HT3A and 5-HT3B subunits as well as the novel 5-HT3C, 5-HT3D, and
5-HT3E
subunits on CPT performance in subjects with
schizophrenia
. The study included 196 patients with
schizophrenia
, 113 of their parents, and 205 healthy controls recruited from community registers. Sustained attention was assessed with the Continuous Performance Test-Identical Pairs (CPT-IP). Assessing functional and coding variants of the 5-HT3 receptor subunit genes, we found the GG genotype of the
5-HT3E
subunit gene (rs7627615; Thr86Ala) to be associated with better attentional capacities in subjects with
schizophrenia
and healthy controls. This study provides additional evidence for a role of the serotonergic system and the 5-HT3 receptor in
schizophrenia
.
...
PMID:A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients. 2035 18
