Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Comparisons were made between personality (MMPI) profiles of 26 part-time university students who scored in the upper and 29 students who scored in the lower one-quarter of the range on a scale that measures temporal-lobe signs in the normal population. Compared to the reference group, the subjects who displayed more temporal-lobe signs showed statistically significant elevations above a T score of 70 on Schizophrenia and Hypomania. There were secondary elevations on Psychasthenia and frequency scales. Similar profiles whose high-point scores display greater amplitude are typical for patients with schizotypal disorders and for many patients who have long histories of temporal lobe epilepsy. These results support the existence of a continuum of temporal-lobe lability that extends into the normal population.
Percept Mot Skills 1987 Jun
PMID:MMPI profiles of normal people who display frequent temporal-lobe signs. 362 13

Repetition in the written language of schizophrenics and its possible relationships to other aspects of schizophrenic disorders are not well understood. We investigated repetitiousness in written utterances, finding schizophrenic subjects to be more repetitive than affective controls and normal controls. Over-all, written repetitiousness was more strongly correlated with psychopathologic features than oral repetitiousness. As in previous work, thought-disordered schizophrenic subjects produced the most repetitive responses. Poverty of content and illogical thinking were correlated with scores for written repetition. Measures of other negative features, disturbed mental functioning and motor behavior were also associated with repetitiousness in both written and oral modes. That these negative features are linked (namely, linguistic repetitiousness, negative formal thought disorder, voluntary motor abnormalities, and deficient mental functioning) is consistent with Crow's concept of a defect syndrome (Type 2) in schizophrenia.
Percept Mot Skills 1987 Jun
PMID:Impoverished written responses and negative features of schizophrenia. 362 17

In a sample of 78 female alcohol and drug addicts, 24.4% marked True the Item 31 ("I have nightmares every few nights") of the MMPI. The proportion is significantly higher than in normative MMPI data of normal US Midwest women published by Coligan: only 8.2% of the latter marked the item True. The female alcohol and drug addicts who marked the item True differed from those responding with False by higher scores on Schizophrenia, Psychasthenia, Paranoia, Anxiety, Depression, Psychopathic Deviate, and Social Introversion scales and by lower scores on Ego Strength scale. Nightmare sufferers consistently scored in a more pathological direction.
Percept Mot Skills 1986 Jun
PMID:MMPI and nightmare reports in women addicted to alcohol and other drugs. 372 11

Internal and external validity tests were completed for an inventory that has been used to infer signs of temporal lobe lability. Strong, positive correlations were reported for a normal (reference) population between the numbers of responses that referred to paranormal experiences (including feelings of a "presence") and separately to religious beliefs and the numbers of spikes per minute within electroencephalographic recordings from the temporal lobe. Numbers of spikes were also correlated with the subjects' scores on the hysteria, schizophrenia, and psychasthenia scales from the MMPI. These clusters of items were not correlated with electrical activity from the occipital lobe (the comparison region). Numbers of responses to control clusters of mundane experiences were not correlated with the temporal lobe measures. A group of student poets scored higher on different subclusters of temporal lobe signs and on the schizophrenia and mania scales of the MMPI than the reference group. For both groups, there were positive correlations between the amount of alpha activity in the temporal lobe only and answers to items such as "hearing inner voices" and "feeling as if things were not real." These results demonstrate that quantitative measures of electrical changes in the temporal lobe are correlated with (or with the report of) specific experiences that are prevalent during surgical or epileptic stimulation of this brain region.
Percept Mot Skills 1985 Jun
PMID:Temporal lobe signs: electroencephalographic validity and enhanced scores in special populations. 392 56

18 RDC-diagnosed schizophrenic patients (11 men, 7 women) were compared to 84 normal men with three computerized neuropsychological methods, assumed to reflect lateralized and frontal cortical functions: (1) Bilateral Finger Tapping and Finger Alternation, (2) Bilateral Trail Making, and (3) passively perceived Necker cube reversals. Schizophrenics differed from normals by (1) inferior Tapping/Alternation but only in the right hand, (2) inferior Trail Making, most pronounced for Form B, and (3) lower frequency of Necker cube reversals. Patients with previous neuroleptic medication and prior psychiatric hospitalizations were inferior in Trail Making and had fewer Necker cube reversals. The findings were interpreted in line with recent models of schizophrenia involving a left-hemisphere dysfunction/over-activation and a frontal dysfunction.
Percept Mot Skills 1985 Oct
PMID:Regional cortical dysfunction in schizophrenic patients studied by computerized neuropsychological methods. 406 13

5 healthy subjects and 9 patients with hospital diagnoses of schizophrenia were studied by means of repeated measurements of time estimation (production method) during a 1- to 2-yr period. The healthy subjects exhibited moderate variability in their time estimations and tended to over- or under-estimate somewhat. Both over- and under-estimation were also found among patients, but the patients were often more variable in their estimations and in some cases deviated more from the correct estimation than the healthy subjects. Two patients were decided under-estimators. They were both young, subchronic schizophrenics. Chronic schizophrenic patients tended to over-estimate time, but the amount of over-estimation had no noticeable correlation to the degree of clinical disturbance. Two patients gradually changed from under- to over-estimation during the observation period. One patient was evidently misdiagnosed. He suffered from a bipolar affective disorder, and his time estimations seemed to depend on his clinical state during the course of the disorder. The results are discussed in the context of earlier findings and physiological disturbances in chronic schizophrenia.
Percept Mot Skills 1984 Dec
PMID:A longitudinal study of time estimation in psychotic disorders. 652 93

The relationship between degree of schizophrenia and neuropsychological impairment was investigated in 24 adolescent and adult hospitalized and non-hospitalized psychiatric patients with diagnoses of depressive disorder, conduct disorder, and schizophrenia. Schizophrenic adults and conduct disordered adolescents showed greater cognitive impairment than depressed patients on a neuropsychological test of rhythm perception and attention and showed greater frequency of EEG abnormality. Schizophrenics were differentiated from other groups by their impaired abstraction ability on the Halstead-Reitan Category Test. Use of these tests for prediction of adolescents at high risk for schizophrenia was discussed.
Percept Mot Skills 1983 Oct
PMID:Schizophrenia, conduct disorder and depressive disorder: neuropsychological, speech sample and EEG results. 663 24

Estimation of short time intervals by 60 healthy subjects, 50 patients with schizophrenic disorders, and 8 with schizotypal personality disorders, was investigated using the three different methods, adjusting a metronome, verbal estimation, and operative estimation (production). The schizophrenic patients tended to over-estimate time with all three methods. Overestimation was also found when longer intervals were studied. Patients with different types of schizophrenic disorders, classified according to DSM-III criteria, over-estimated time about the same; no significant differences were found. Different courses of schizophrenia were also studied. Patients in remission over-estimated time to the same extent as chronic patients; the subchronic patients probably over-estimated less. Schizotypal personality disorders did not seem to be associated with a tendency to over-estimate short time intervals. The results were discussed in the context of perceptual disturbances in schizophrenic disorders.
Percept Mot Skills 1983 Dec
PMID:Estimation of time and the subclassification of schizophrenic disorders. 666 72

A set of monozygotic female quadruplets developed schizophrenia at age 26 and were treated at the National Institute of Mental Health for several years. Using graphic material of these unusual subjects, this study demonstrates how handwriting, statistically in graph forms, expresses the developmental stages before (at age 16), during the acute phase of the disease (age 26 to 28) and 25 yr. later (age 51) when they functioned outside a hospital setting in various degrees of competency.
Percept Mot Skills 1983 Feb
PMID:The Genain Quadruplets at age 51: report of handwriting assessment. 668 49

Neuropsychological performance of schizophrenics with and without brain-damage was measured by the Whitaker Index of Schizophrenic Thinking and the Luria-Nebraska Neuropsychological Battery. Inpatient volunteers (11 brain-damaged and 15 non-brain-damaged) with a diagnosis of schizophrenia were administered both tests individually. Results indicated that 8 of the 14 summary scales of the Luria-Nebraska but none of the 5 scores on the Whitaker differentiated between groups. While cognitive variables as measured by the Whitaker may be further impaired with organicity, other variables measured by the Luria-Nebraska were more effective in differentiating between groups.
Percept Mot Skills 1982 Apr
PMID:Detection of brain-damage in schizophrenics as measured by the Whitaker Index of Schizophrenic Thinking and the Luria-Nebraska Neuropsychological Battery. 707 75


<< Previous 1 2 3 4 5 6 Next >>