Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Tryptamine (Try), 5-methoxytryptamine (5MeOT), N-methyltryptamine (N-Met), 5-methoxy-N,N-dimethyltryptamine (5MeODMT) and N,N-dimethyltryptamine (DMT) are metabolites of the neurotransmitter 5-hydroxytryptamine (5HT). The cisternal cerebrospinal fluid (CSF) is probably a suitable biological material for investigating the problem of indolamine metabolism in schizophrenic patients. As part of a biological research programme on schizophrenia we have investigated concentrations of cisternal CSF indolamines in a group of acute paranoid patients in comparison with psychiatrically healthy controls. The concentrations of indolamines in the cisternal CSF reveal that psychotomimetic indolamines like 5MeODMT, 5MeOT and DMT and the indolamines N-Met and Try are present in psychological and pathological states. The patients suffering from acute paranoid schizophrenia have high or very high levels of the investigated indolamines in comparison with healthy controls, but there are significant individual differences in the group of these patients. The search for correlations between the level of a single indolamine and individual psychopathological symptoms could provide more specific information for diagnosis or treatment.
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PMID:[Methylated and unmethylated indolamine in the cisternal fluid in acute endogenous psychoses]. 614 8

Platelet MAO activity was estimated in 60 male drug free schizophrenics, 36 male drug free manics and 30 male normal healthy controls by Radio Isotopic Technique using (14)C Tryptamine Bisuccinate as substrate. There was no significant difference between the enzyme activity in the schizophrenic, manic and control groups. Platelet MAO activity in the disorganized catatonic and paranoid schizophrenics was significantly lower as compared to the enzyme activity in the manic and healthy control group. Platelet MAO activity appears to be related to subgroups of schizophrenia disorganized, catatonic and paranoid. Limitations and scope for future research have been outlined.
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PMID:Platelet mao activity in subgroups of schizophrenia. 2192 85